HUMAN:NFKB1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	NFKB1
Protein Name(s)	Nuclear factor NF-kappa-B p105 subunit DNA-binding factor KBF1 EBP-1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nuclear factor NF-kappa-B p50 subunit
External Links
UniProt Identifier	NFKB1_HUMAN
UniProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0,
EMBL	M55643, M58603, Z47748, Z47749, Z47750, Z47751, Z47752, Z47753, Z47754, Z47755, Z47734, Z47735, Z47736, Z47737, Z47738, Z47739, Z47740, Z47741, Z47742, Z47743, Z47744, AF213884, CR749522, AY223820, BC033210, BC051765,
PIR	A37867,
RefSeq	NP_001158884.1, NP_003989.2,
PDB	1MDI, 1MDJ, 1MDK, 1NFI, 1SVC, 2DBF, 2O61, 3GUT,
IntAct	P19838,
Ensembl	ENST00000394820,
Pfam	PF00023, PF00531, PF00554,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0002224	toll-like receptor signaling pathway	Reactome:REACT_8006	TAS: Traceable Author Statement		P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	PMID:15276183^[1]	EXP: Inferred from Experiment		P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_27215	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	PMID:15276183^[1]	EXP: Inferred from Experiment		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6782	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6976	TAS: Traceable Author Statement		P
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000451	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008967	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011539	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:10928981^[2]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:10498867^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q04206	F
	GO:0005515	protein binding	PMID:11526476^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O00255	F
	GO:0005515	protein binding	PMID:11931769^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q13547	F
	GO:0005515	protein binding	PMID:14624448^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q14690	F
	GO:0005515	protein binding	PMID:14624448^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q14690	F
	GO:0005515	protein binding	PMID:14743216^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O60271	F
	GO:0005515	protein binding	PMID:15169888^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NFZ5	F
	GO:0005515	protein binding	PMID:15799966^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N668	F
	GO:0005515	protein binding	PMID:16108830^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P20749	F
	GO:0005515	protein binding	PMID:16306601^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P20749	F
	GO:0005515	protein binding	PMID:18045535^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P23396	F
	GO:0005515	protein binding	PMID:20195357^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IV08	F
	GO:0005515	protein binding	PMID:20195357^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IZL8	F
	GO:0005515	protein binding	PMID:8196632^[14]	IPI: Inferred from Physical Interaction	UniProtKB:P20749	F
	GO:0005515	protein binding	PMID:8441377^[15]	IPI: Inferred from Physical Interaction	UniProtKB:Q04206	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000451	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011539	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:11819787^[16]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:16938301^[17]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18029348^[18]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:1992489^[19]	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	PMID:15496460^[20]	EXP: Inferred from Experiment		C
	GO:0005654	nucleoplasm	Reactome:REACT_6906	TAS: Traceable Author Statement		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:11819787^[16]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:18029348^[18]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:18029348^[18]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:12482991^[21]	EXP: Inferred from Experiment		C
	GO:0005829	cytosol	PMID:12843241^[22]	EXP: Inferred from Experiment		C
	GO:0005829	cytosol	PMID:14673179^[23]	EXP: Inferred from Experiment		C
	GO:0005829	cytosol	PMID:15496460^[20]	EXP: Inferred from Experiment		C
	GO:0005829	cytosol	PMID:9252186^[24]	EXP: Inferred from Experiment		C
	GO:0005829	cytosol	Reactome:REACT_12399	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22206	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22353	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6848	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6906	TAS: Traceable Author Statement		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000451	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006366	transcription from RNA polymerase II promoter	PMID:1992489^[19]	TAS: Traceable Author Statement		P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006916	anti-apoptosis	PMID:10811897^[25]	TAS: Traceable Author Statement		P
	GO:0006916	anti-apoptosis	PMID:16997282^[26]	EXP: Inferred from Experiment		P
	GO:0006954	inflammatory response	PMID:1992489^[19]	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000488	P
	GO:0008063	Toll signaling pathway	Reactome:REACT_6894	TAS: Traceable Author Statement		P
	GO:0010553	negative regulation of gene-specific transcription from RNA polymerase II promoter	PMID:16938301^[17]	IC: Inferred by Curator	GO:0005634	P
	GO:0010744	positive regulation of macrophage derived foam cell differentiation	PMID:16938301^[17]	IC: Inferred by Curator	GO:0005634	P
	GO:0010843	promoter binding	PMID:16938301^[17]	IDA: Inferred from Direct Assay		F
	GO:0010884	positive regulation of lipid storage	PMID:16938301^[17]	IC: Inferred by Curator	GO:0005634	P
	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity	PMID:15243130^[27]	IDA: Inferred from Direct Assay		P
	GO:0010957	negative regulation of vitamin D biosynthetic process	PMID:15243130^[27]	IC: Inferred by Curator	GO:0010956	P
	GO:0016563	transcription activator activity	PMID:20018240^[28]	IMP: Inferred from Mutant Phenotype		F
	GO:0031293	membrane protein intracellular domain proteolysis	PMID:17986144^[29]	EXP: Inferred from Experiment		P
	GO:0032269	negative regulation of cellular protein metabolic process	PMID:16938301^[17]	IC: Inferred by Curator	GO:0005634	P
	GO:0032375	negative regulation of cholesterol transport	PMID:16938301^[17]	IC: Inferred by Curator	GO:0005634	P
	GO:0033256	I-kappaB/NF-kappaB complex	PMID:16938301^[17]	TAS: Traceable Author Statement		C
	GO:0034130	toll-like receptor 1 signaling pathway	Reactome:REACT_8005	TAS: Traceable Author Statement		P
	GO:0034134	toll-like receptor 2 signaling pathway	Reactome:REACT_7980	TAS: Traceable Author Statement		P
	GO:0034138	toll-like receptor 3 signaling pathway	Reactome:REACT_6783	TAS: Traceable Author Statement		P
	GO:0034142	toll-like receptor 4 signaling pathway	Reactome:REACT_6890	TAS: Traceable Author Statement		P
	GO:0045087	innate immune response	Reactome:REACT_6802	TAS: Traceable Author Statement		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:20018240^[28]	IMP: Inferred from Mutant Phenotype		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:8096091^[30]	NAS: Non-traceable Author Statement		P
	GO:0048011	nerve growth factor receptor signaling pathway	Reactome:REACT_11061	TAS: Traceable Author Statement		P
	GO:0048011	nerve growth factor receptor signaling pathway	Reactome:REACT_13776	TAS: Traceable Author Statement		P
	GO:0050852	T cell receptor signaling pathway	Reactome:REACT_12526	TAS: Traceable Author Statement		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Reactome:REACT_21281	TAS: Traceable Author Statement		P
	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[31]	IEP: Inferred from Expression Pattern		P
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	PMID:20018240^[28]	IMP: Inferred from Mutant Phenotype		P
	GO:0005730	nucleolus	PMID:18029348^[18]	IDA: Inferred from Direct Assay		C
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:16938301^[17]	IC: Inferred by Curator	GO:0005634	P
	GO:0002224	toll-like receptor signaling pathway	Reactome:REACT_8006	TAS: Traceable Author Statement		P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_27215	TAS: Traceable Author Statement		P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_6788	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6782	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6976	TAS: Traceable Author Statement		P
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000451	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008967	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011539	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:10928981^[2]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:10498867^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q04206	F
	GO:0005515	protein binding	PMID:11526476^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O00255	F
	GO:0005515	protein binding	PMID:11931769^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q13547	F
	GO:0005515	protein binding	PMID:14624448^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q14690	F
	GO:0005515	protein binding	PMID:14624448^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q14690	F
	GO:0005515	protein binding	PMID:14743216^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O60271	F
	GO:0005515	protein binding	PMID:15169888^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NFZ5	F
	GO:0005515	protein binding	PMID:15799966^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N668	F
	GO:0005515	protein binding	PMID:16108830^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P20749	F
	GO:0005515	protein binding	PMID:16306601^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P20749	F
	GO:0005515	protein binding	PMID:18045535^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P23396	F
	GO:0005515	protein binding	PMID:20195357^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IV08	F
	GO:0005515	protein binding	PMID:20195357^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IZL8	F
	GO:0005515	protein binding	PMID:8196632^[14]	IPI: Inferred from Physical Interaction	UniProtKB:P20749	F
	GO:0005515	protein binding	PMID:8441377^[15]	IPI: Inferred from Physical Interaction	UniProtKB:Q04206	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000451	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011539	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:11819787^[16]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:16938301^[17]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18029348^[18]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:1992489^[19]	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_13816	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_6906	TAS: Traceable Author Statement		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:11819787^[16]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:18029348^[18]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:18029348^[18]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	Reactome:REACT_12399	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13446	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13502	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_13816	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22206	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22353	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22407	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22418	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6848	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6906	TAS: Traceable Author Statement		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000451	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008967	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011539	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006366	transcription from RNA polymerase II promoter	PMID:1992489^[19]	TAS: Traceable Author Statement		P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006916	anti-apoptosis	PMID:10811897^[25]	TAS: Traceable Author Statement		P
	GO:0006916	anti-apoptosis	Reactome:REACT_13537	TAS: Traceable Author Statement		P
	GO:0006954	inflammatory response	PMID:1992489^[19]	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000488	P
	GO:0008063	Toll signaling pathway	Reactome:REACT_6894	TAS: Traceable Author Statement		P
	GO:0010744	positive regulation of macrophage derived foam cell differentiation	PMID:16938301^[17]	IC: Inferred by Curator	GO:0005634	P
	GO:0010884	positive regulation of lipid storage	PMID:16938301^[17]	IC: Inferred by Curator	GO:0005634	P
	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity	PMID:15243130^[27]	IDA: Inferred from Direct Assay		P
	GO:0010957	negative regulation of vitamin D biosynthetic process	PMID:15243130^[27]	IC: Inferred by Curator	GO:0010956	P
	GO:0031293	membrane protein intracellular domain proteolysis	Reactome:REACT_13443	TAS: Traceable Author Statement		P
	GO:0032269	negative regulation of cellular protein metabolic process	PMID:16938301^[17]	IC: Inferred by Curator	GO:0005634	P
	GO:0032375	negative regulation of cholesterol transport	PMID:16938301^[17]	IC: Inferred by Curator	GO:0005634	P
	GO:0033256	I-kappaB/NF-kappaB complex	PMID:16938301^[17]	TAS: Traceable Author Statement		C
	GO:0034130	toll-like receptor 1 signaling pathway	Reactome:REACT_8005	TAS: Traceable Author Statement		P
	GO:0034134	toll-like receptor 2 signaling pathway	Reactome:REACT_7980	TAS: Traceable Author Statement		P
	GO:0034138	toll-like receptor 3 signaling pathway	Reactome:REACT_6783	TAS: Traceable Author Statement		P
	GO:0034142	toll-like receptor 4 signaling pathway	Reactome:REACT_6890	TAS: Traceable Author Statement		P
	GO:0044212	transcription regulatory region DNA binding	PMID:16938301^[17]	IDA: Inferred from Direct Assay		F
	GO:0045087	innate immune response	Reactome:REACT_6802	TAS: Traceable Author Statement		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:20018240^[28]	IMP: Inferred from Mutant Phenotype		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:8096091^[30]	NAS: Non-traceable Author Statement		P
	GO:0048011	nerve growth factor receptor signaling pathway	Reactome:REACT_11061	TAS: Traceable Author Statement		P
	GO:0048011	nerve growth factor receptor signaling pathway	Reactome:REACT_13776	TAS: Traceable Author Statement		P
	GO:0050852	T cell receptor signaling pathway	Reactome:REACT_12526	TAS: Traceable Author Statement		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Reactome:REACT_21281	TAS: Traceable Author Statement		P
	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[31]	IEP: Inferred from Expression Pattern		P
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	PMID:20018240^[28]	IMP: Inferred from Mutant Phenotype		P
NOT	GO:0005730	nucleolus	PMID:18029348^[18]	IDA: Inferred from Direct Assay		C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Gangloff M & Gay NJ (2004) MD-2: the Toll 'gatekeeper' in endotoxin signalling. Trends Biochem Sci 29: 294-300 PubMed GONUTS page
↑ ^2.0 ^2.1 Schulte R et al. (2000) Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers. FASEB J 14: 1471-84 PubMed GONUTS page
↑ ^3.0 ^3.1 Yang JP et al. (1999) NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2. Oncogene 18: 5177-86 PubMed GONUTS page
↑ ^4.0 ^4.1 Heppner C et al. (2001) The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene 20: 4917-25 PubMed GONUTS page
↑ ^5.0 ^5.1 Zhong H et al. (2002) The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 9: 625-36 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Sweet T et al. (2003) Identification of a novel protein from glial cells based on its ability to interact with NF-kappaB subunits. J Cell Biochem 90: 884-91 PubMed GONUTS page
↑ ^7.0 ^7.1 Bouwmeester T et al. (2004) A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol 6: 97-105 PubMed GONUTS page
↑ ^8.0 ^8.1 Lang V et al. (2004) ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. Mol Cell Biol 24: 5235-48 PubMed GONUTS page
↑ ^9.0 ^9.1 Burstein E et al. (2005) COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem 280: 22222-32 PubMed GONUTS page
↑ ^10.0 ^10.1 Nishikori M et al. (2005) Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3. Cancer Sci 96: 487-97 PubMed GONUTS page
↑ ^11.0 ^11.1 Jamaluddin M et al. (2005) Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter. J Virol 79: 15302-13 PubMed GONUTS page
↑ ^12.0 ^12.1 Wan F et al. (2007) Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. Cell 131: 927-39 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Miyamoto-Sato E et al. (2010) A comprehensive resource of interacting protein regions for refining human transcription factor networks. PLoS One 5: e9289 PubMed GONUTS page
↑ ^14.0 ^14.1 Zhang Q et al. (1994) BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins. Mol Cell Biol 14: 3915-26 PubMed GONUTS page
↑ ^15.0 ^15.1 Duckett CS et al. (1993) Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3). Mol Cell Biol 13: 1315-22 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Guo SP et al. (2001) Expression of nuclear factor-kappa B in hepatocellular carcinoma and its relation with the X protein of hepatitis B virus. World J Gastroenterol 7: 340-4 PubMed GONUTS page
↑ ^17.00 ^17.01 ^17.02 ^17.03 ^17.04 ^17.05 ^17.06 ^17.07 ^17.08 ^17.09 ^17.10 ^17.11 ^17.12 ^17.13 ^17.14 ^17.15 Ferreira V et al. (2007) Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation. Atherosclerosis 192: 283-90 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Meyer R et al. (1991) Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha. Proc Natl Acad Sci U S A 88: 966-70 PubMed GONUTS page
↑ ^20.0 ^20.1 Salama-Cohen P et al. (2005) NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch. Mol Biol Cell 16: 339-47 PubMed GONUTS page
↑ Lang V et al. (2003) betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol Cell Biol 23: 402-13 PubMed GONUTS page
↑ Kanning KC et al. (2003) Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J Neurosci 23: 5425-36 PubMed GONUTS page
↑ Cohen S et al. (2004) Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing. Mol Cell Biol 24: 475-86 PubMed GONUTS page
↑ DiDonato JA et al. (1997) A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388: 548-54 PubMed GONUTS page
↑ ^25.0 ^25.1 Cahir-McFarland ED et al. (2000) NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells. Proc Natl Acad Sci U S A 97: 6055-60 PubMed GONUTS page
↑ Mémet S (2006) NF-kappaB functions in the nervous system: from development to disease. Biochem Pharmacol 72: 1180-95 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 Ebert R et al. (2004) Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter. Mol Endocrinol 18: 2440-50 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 ^28.4 Medici D & Nawshad A (2010) Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1. Matrix Biol 29: 161-5 PubMed GONUTS page
↑ Bronfman FC (2007) Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling? J Neurochem 103 Suppl 1: 91-100 PubMed GONUTS page
↑ ^30.0 ^30.1 Sun SC et al. (1993) NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 259: 1912-5 PubMed GONUTS page
↑ ^31.0 ^31.1 Smith AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS One 4: e6224 PubMed GONUTS page

[PMID:15276183-0] 1.0 ^1.1 Gangloff M & Gay NJ (2004) MD-2: the Toll 'gatekeeper' in endotoxin signalling. Trends Biochem Sci 29: 294-300 PubMed GONUTS page

[PMID:10928981-1] 2.0 ^2.1 Schulte R et al. (2000) Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers. FASEB J 14: 1471-84 PubMed GONUTS page

[PMID:10498867-2] 3.0 ^3.1 Yang JP et al. (1999) NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2. Oncogene 18: 5177-86 PubMed GONUTS page

[PMID:11526476-3] 4.0 ^4.1 Heppner C et al. (2001) The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene 20: 4917-25 PubMed GONUTS page

[PMID:11931769-4] 5.0 ^5.1 Zhong H et al. (2002) The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 9: 625-36 PubMed GONUTS page

[PMID:14624448-5] 6.0 ^6.1 ^6.2 ^6.3 Sweet T et al. (2003) Identification of a novel protein from glial cells based on its ability to interact with NF-kappaB subunits. J Cell Biochem 90: 884-91 PubMed GONUTS page

[PMID:14743216-6] 7.0 ^7.1 Bouwmeester T et al. (2004) A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol 6: 97-105 PubMed GONUTS page

[PMID:15169888-7] 8.0 ^8.1 Lang V et al. (2004) ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. Mol Cell Biol 24: 5235-48 PubMed GONUTS page

[PMID:15799966-8] 9.0 ^9.1 Burstein E et al. (2005) COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem 280: 22222-32 PubMed GONUTS page

[PMID:16108830-9] 10.0 ^10.1 Nishikori M et al. (2005) Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3. Cancer Sci 96: 487-97 PubMed GONUTS page

[PMID:16306601-10] 11.0 ^11.1 Jamaluddin M et al. (2005) Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter. J Virol 79: 15302-13 PubMed GONUTS page

[PMID:18045535-11] 12.0 ^12.1 Wan F et al. (2007) Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. Cell 131: 927-39 PubMed GONUTS page

[PMID:20195357-12] 13.0 ^13.1 ^13.2 ^13.3 Miyamoto-Sato E et al. (2010) A comprehensive resource of interacting protein regions for refining human transcription factor networks. PLoS One 5: e9289 PubMed GONUTS page

[PMID:8196632-13] 14.0 ^14.1 Zhang Q et al. (1994) BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins. Mol Cell Biol 14: 3915-26 PubMed GONUTS page

[PMID:8441377-14] 15.0 ^15.1 Duckett CS et al. (1993) Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3). Mol Cell Biol 13: 1315-22 PubMed GONUTS page

[PMID:11819787-15] 16.0 ^16.1 ^16.2 ^16.3 Guo SP et al. (2001) Expression of nuclear factor-kappa B in hepatocellular carcinoma and its relation with the X protein of hepatitis B virus. World J Gastroenterol 7: 340-4 PubMed GONUTS page

[PMID:16938301-16] 17.00 ^17.01 ^17.02 ^17.03 ^17.04 ^17.05 ^17.06 ^17.07 ^17.08 ^17.09 ^17.10 ^17.11 ^17.12 ^17.13 ^17.14 ^17.15 Ferreira V et al. (2007) Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation. Atherosclerosis 192: 283-90 PubMed GONUTS page

[PMID:18029348-17] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:1992489-18] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Meyer R et al. (1991) Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha. Proc Natl Acad Sci U S A 88: 966-70 PubMed GONUTS page

[PMID:15496460-19] 20.0 ^20.1 Salama-Cohen P et al. (2005) NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch. Mol Biol Cell 16: 339-47 PubMed GONUTS page

[PMID:12482991-20] Lang V et al. (2003) betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol Cell Biol 23: 402-13 PubMed GONUTS page

[PMID:12843241-21] Kanning KC et al. (2003) Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J Neurosci 23: 5425-36 PubMed GONUTS page

[PMID:14673179-22] Cohen S et al. (2004) Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing. Mol Cell Biol 24: 475-86 PubMed GONUTS page

[PMID:9252186-23] DiDonato JA et al. (1997) A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388: 548-54 PubMed GONUTS page

[PMID:10811897-24] 25.0 ^25.1 Cahir-McFarland ED et al. (2000) NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells. Proc Natl Acad Sci U S A 97: 6055-60 PubMed GONUTS page

[PMID:16997282-25] Mémet S (2006) NF-kappaB functions in the nervous system: from development to disease. Biochem Pharmacol 72: 1180-95 PubMed GONUTS page

[PMID:15243130-26] 27.0 ^27.1 ^27.2 ^27.3 Ebert R et al. (2004) Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter. Mol Endocrinol 18: 2440-50 PubMed GONUTS page

[PMID:20018240-27] 28.0 ^28.1 ^28.2 ^28.3 ^28.4 Medici D & Nawshad A (2010) Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1. Matrix Biol 29: 161-5 PubMed GONUTS page

[PMID:17986144-28] Bronfman FC (2007) Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling? J Neurochem 103 Suppl 1: 91-100 PubMed GONUTS page

[PMID:8096091-29] 30.0 ^30.1 Sun SC et al. (1993) NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 259: 1912-5 PubMed GONUTS page

[PMID:19593445-30] 31.0 ^31.1 Smith AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS One 4: e6224 PubMed GONUTS page

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