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CANAL:HSP90

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0048523

negative regulation of cellular process

PMID:23300438

ECO:0000314

P

Hsf1 downregulats Hsp90 in C.albicans as shown in figure 1 by Western Blot

complete
CACAO 9290

protected

enables

GO:0051082

unfolded protein binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001233
PANTHER:PTN000163629
PomBase:SPAC926.04c
SGD:S000004798
SGD:S000006161

F

Seeded From UniProt

complete

protected

involved_in

GO:0050821

protein stabilization

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000163629
UniProtKB:P07900
UniProtKB:P11501

P

Seeded From UniProt

complete

public

GO:0080135

regulation of cellular response to stress

PMID:23300438

ECO:0000314

P

Hsp90 in C. albicans regulates the stress response of the cells (heat shock and non-heat shock). In figure 8, Hsp90 was depleted from the cell using the drug doxycycline. When Hsp90 was depleted, the cells were less stress resistance. The stress resistance was measured by CFU (Colony-forming Unit) measurement.

complete
CACAO 9301

protected

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001233
MGI:MGI:96250
PANTHER:PTN000163629
RGD:631409
WB:WBGene00000915

C

Seeded From UniProt

complete

public

GO:0048523

negative regulation of cellular process

PMID:23300438

ECO:0000314

P

Hsp90 in C. albicans down-regulates Hsp104 under heat shock conditions as shown in Figure 1. Hsp90 was depleted using doxycycline and mRNA levels were measured through Western Blot.

complete
CACAO 9296

protected

enables

GO:0042623

ATPase activity, coupled

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000201062
PANTHER:PTN000898156
SGD:S000006161

F

Seeded From UniProt

complete

protected

involved_in

GO:0034605

cellular response to heat

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000201062
PANTHER:PTN000163629
SGD:S000004798

P

Seeded From UniProt

complete

protected

part_of

GO:0032991

protein-containing complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000163629
RGD:631409
UniProtKB:P07900
UniProtKB:P11501
WB:WBGene00000915

C

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000201062
PANTHER:PTN000163629
RGD:631409
UniProtKB:P11501

C

Seeded From UniProt

complete

protected

involved_in

GO:0009408

response to heat

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000201062
FB:FBgn0001233
PANTHER:PTN000163629
RGD:631409
SGD:S000004798
UniProtKB:P11501

P

Seeded From UniProt

complete

protected

part_of

GO:0009277

fungal-type cell wall

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000201062
PANTHER:PTN000898156
UniProtKB:P40292

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000201062
MGI:MGI:96250
PANTHER:PTN000163629
RGD:631409
TAIR:locus:2161775
TAIR:locus:2161790
UniProtKB:P11501

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96250
PANTHER:PTN000163629
RGD:631409
TAIR:locus:2161775
UniProtKB:P11501
UniProtKB:P40292
dictyBase:DDB_G0267400

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000201062
FB:FBgn0001233
MGI:MGI:96250
PANTHER:PTN000163629
RGD:631409
SGD:S000006161
TAIR:locus:2161775
TAIR:locus:2161790
UniProtKB:P07900
UniProtKB:P11501
UniProtKB:P40292
UniProtKB:Q76LV2
UniProtKB:Q8I0V4
WB:WBGene00000915
ZFIN:ZDB-GENE-990415-94
dictyBase:DDB_G0267400

C

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000898156
PomBase:SPAC926.04c

F

Seeded From UniProt

complete

protected

involved_in

GO:1900429

negative regulation of filamentous growth of a population of unicellular organisms

PMID:22365851

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0044182

filamentous growth of a population of unicellular organisms

PMID:22365851

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0044182

filamentous growth of a population of unicellular organisms

PMID:22090345

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042981

regulation of apoptotic process

PMID:23028789

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0042623

ATPase activity, coupled

PMID:10627043

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000004798
SGD:S000006161

F

Seeded From UniProt

complete

protected

involved_in

GO:0035690

cellular response to drug

PMID:22365851

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035690

cellular response to drug

PMID:19649312

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035690

cellular response to drug

PMID:19196973

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035690

cellular response to drug

PMID:16195452

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034605

cellular response to heat

PMID:22365851

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034605

cellular response to heat

PMID:7591093

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030518

intracellular steroid hormone receptor signaling pathway

PMID:10627043

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000004798
SGD:S000006161

P

Seeded From UniProt

complete

protected

involved_in

GO:0030447

filamentous growth

PMID:22365851

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030447

filamentous growth

PMID:22090345

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030447

filamentous growth

PMID:19327993

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0030446

hyphal cell wall

PMID:12782322

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

PMID:16534748

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

PMID:12782322

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0009405

pathogenesis

PMID:19327993

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0009405

pathogenesis

PMID:19196973

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0009277

fungal-type cell wall

PMID:12661902

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0006457

protein folding

PMID:10627043

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000004798
SGD:S000006161

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:19824013

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:12661902

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001404
InterPro:IPR019805

F

Seeded From UniProt

complete

protected

involved_in

GO:0006457

protein folding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001404
InterPro:IPR019805

P

Seeded From UniProt

complete

protected

enables

GO:0051082

unfolded protein binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001404
InterPro:IPR019805

F

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

protected

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete



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