TableEdit

Olesnicky, E, Hernandez-Lagunas, L and Artinger, KB (2010) prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons. Genesis 48:656-66

The PR domain containing 1a, with ZNF domain factor, gene (prdm1a) plays an integral role in the development of a number of different cell types during vertebrate embryogenesis, including neural crest cells, Rohon-Beard (RB) sensory neurons and the cranial neural crest-derived craniofacial skeletal elements. To better understand how Prdm1a regulates the development of various cell types in zebrafish, we performed a microarray analysis comparing wild type and prdm1a mutant embryos and identified a number of genes with altered expression in the absence of prdm1a. Rescue analysis determined that two of these, sox10 and islet1, lie downstream of Prdm1a in the development of neural crest cells and RB neurons, respectively. In addition, we identified a number of other novel downstream targets of Prdm1a that may be important for the development of diverse tissues during zebrafish embryogenesis.

PubMed PMC3119337 Online version:10.1002/dvg.20673

Animals; Animals, Genetically Modified; Body Patterning/genetics; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; DNA-Binding Proteins/physiology; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Gene Regulatory Networks/physiology; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; LIM-Homeodomain Proteins; Neural Crest/embryology; Neural Crest/metabolism; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Nuclear Proteins/physiology; SOXE Transcription Factors/genetics; SOXE Transcription Factors/metabolism; Sensory Receptor Cells/metabolism; Sensory Receptor Cells/physiology; Transcription Factors; Zebrafish/embryology; Zebrafish/genetics; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism; Zebrafish Proteins/physiology