GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:18838381
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
Citation |
Lin, Z, Gao, C, Ning, Y, He, X, Wu, W and Chen, YG (2008) The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling. J. Biol. Chem. 283:33053-8 |
---|---|
Abstract |
The canonical Wnt/beta-catenin pathway plays a pivotal role in regulating embryogenesis and tumorigenesis by promoting cell proliferation. BAMBI (BMP and activin membrane-bound inhibitor) has previously been shown to negatively regulate the signaling activity of transforming growth factor-beta, activin, and BMP and was identified as a target of beta-catenin in colorectal and hepatocellular tumor cells. In this study, we provide evidence that BAMBI can promote the transcriptional activity of Wnt/beta-catenin signaling. Overexpression of BAMBI enhances the expression of Wnt-responsive reporters, whereas knockdown of endogenous BAMBI attenuates them. Accordingly, BAMBI also promotes the nuclear translocation of beta-catenin. BAMBI interacts with Wnt receptor Frizzled5, coreceptor LRP6, and Dishevelled2 and increases the interaction between Frizzled5 and Dishevelled2. Finally we show that BAMBI promotes the expression of c-myc and cyclin D1 and increases Wnt-promoted cell cycle progression. Altogether, our data indicate that BAMBI can function as a positive regulator of the Wnt/beta-catenin pathway to promote cell proliferation. |
Links |
PubMed PMC2662247 Online version:10.1074/jbc.M804039200 |
Keywords |
Active Transport, Cell Nucleus/physiology; Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/metabolism; Cell Cycle/physiology; Cell Line, Tumor; Cell Nucleus/genetics; Cell Nucleus/metabolism; Cyclin D1/genetics; Cyclin D1/metabolism; Frizzled Receptors/genetics; Frizzled Receptors/metabolism; Humans; LDL-Receptor Related Proteins/genetics; LDL-Receptor Related Proteins/metabolism; Low Density Lipoprotein Receptor-Related Protein-6; Membrane Proteins/genetics; Membrane Proteins/metabolism; Phosphoproteins/genetics; Phosphoproteins/metabolism; Proto-Oncogene Proteins c-myc/genetics; Proto-Oncogene Proteins c-myc/metabolism; Signal Transduction/physiology; Transcription, Genetic/physiology; Transforming Growth Factor beta/genetics; Transforming Growth Factor beta/metabolism; Wnt Proteins/genetics; Wnt Proteins/metabolism; beta Catenin/genetics; beta Catenin/metabolism |
public |
Cancel |