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PMID:14597571
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| Citation |
Lee, M, Lee, S, Zadeh, AD and Kolodziej, PA (2003) Distinct sites in E-cadherin regulate different steps in Drosophila tracheal tube fusion. Development 130:5989-99 |
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| Abstract |
We have investigated how E-cadherin controls the elaboration of adherens junction associated cytoskeletal structures crucial for assembling tubular networks. During Drosophila development, tracheal branches are joined at branch tips through lumens that traverse doughnut-shaped fusion cells. Fusion cells form E-cadherin contacts associated with a track that contains F-actin, microtubules, and Shot, a plakin that binds F-actin and microtubules. Live imaging reveals that fusion occurs as the fusion cell apical surfaces meet after invaginating along the track. Initial track assembly requires E-cadherin binding to beta-catenin. Surprisingly, E-cadherin also controls track maturation via a juxtamembrane site in the cytoplasmic domain. Fusion cells expressing an E-cadherin mutant in this site form incomplete tracks that contain F-actin and Shot, but lack microtubules. These results indicate that E-cadherin controls track initiation and maturation using distinct, evolutionarily conserved signals to F-actin and microtubules, and employs Shot to promote adherens junction-associated cytoskeletal assembly. |
| Links |
PubMed Online version:10.1242/dev.00806 |
| Keywords |
Actins/metabolism; Adherens Junctions/metabolism; Animals; Cadherins/genetics; Cadherins/metabolism; Cell Fusion; Cytoskeletal Proteins/metabolism; Cytoskeleton/metabolism; Drosophila/anatomy & histology; Drosophila/embryology; Drosophila/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Microfilament Proteins/genetics; Microfilament Proteins/metabolism; Microtubules/metabolism; Morphogenesis/physiology; Mutation; Protein Structure, Tertiary; Signal Transduction; Trans-Activators/metabolism; beta Catenin |
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