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PMID:10774727
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| Citation |
Cassata, G, Kagoshima, H, Andachi, Y, Kohara, Y, Dürrenberger, MB, Hall, DH and Bürglin, TR (2000) The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans. Neuron 25:587-97 |
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| Abstract |
In Caenorhabditis elegans three pairs of neurons, AFD, AIY, and AIZ, play a key role in thermosensation. The LIM homeobox gene ceh-14 is expressed in the AFD thermosensory neurons. ceh-14 mutant animals display athermotactic behaviors, although the neurons are still present and differentiated. Two other LIM homeobox genes, ttx-3 and lin-11, function in the two interneurons AIY and AIZ, respectively. Thus, the three key thermosensory neurons are specified by three different LIM homeobox genes. ceh-14 ttx-3 lin-11 triple mutant animals have a basic cryophilic thermotaxis behavior indicative of a second thermotaxis pathway. Misexpression of ceh-14 in chemosensory neurons can restore thermotactic behavior without impairing the chemosensory function. Thus, ceh-14 confers thermosensory function to neurons. |
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| Keywords |
Amino Acid Sequence; Animals; Animals, Genetically Modified; Behavior, Animal/physiology; Body Temperature Regulation/genetics; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins; Gene Deletion; Gene Expression/physiology; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Hot Temperature; Interneurons/physiology; LIM-Homeodomain Proteins; Molecular Sequence Data; Motor Neurons/physiology; Movement/physiology; Mutagenesis/physiology; Neurons, Afferent/chemistry; Neurons, Afferent/physiology; Neuropeptides/genetics; Transcription Factors |
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