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HUMAN:KCNE2

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0006811

ion transport

PMID:22880098

ECO:0000247

UniProtKB:

P

Figure 4: Activation time constants for Ih in pyramidal cells were fast in both genotypes compared to those in VB neurons, Kcne2 deletion again increased time constants in pyramidal neurons Figure 6: he frequency of spontaneous EPSPs in layer 6 pyramidal neurons in the absence of 4-AP was increased by Kcne2 deletion, suggesting a possible alteration in glutamate release machinery.

complete
CACAO 10709

protected

part_of

GO:0005886

plasma membrane

PMID:20533308

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

colocalizes_with

GO:0008076

voltage-gated potassium channel complex

PMID:19219384

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:19219384

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0015459

potassium channel regulator activity

PMID:19219384

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:1902260

negative regulation of delayed rectifier potassium channel activity

PMID:19219384

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0098915

membrane repolarization during ventricular cardiac muscle cell action potential

PMID:10219239

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:1902282

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

PMID:10219239

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:1902259

regulation of delayed rectifier potassium channel activity

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1901979

regulation of inward rectifier potassium channel activity

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1901800

positive regulation of proteasomal protein catabolic process

PMID:22180649

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(UniProtKB:Q12809)

Seeded From UniProt

complete

protected

involved_in

GO:1901379

regulation of potassium ion transmembrane transport

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0086091

regulation of heart rate by cardiac conduction

PMID:10219239

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0086011

membrane repolarization during action potential

PMID:10219239

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0086009

membrane repolarization

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0086005

ventricular cardiac muscle cell action potential

PMID:10219239

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0086002

cardiac muscle cell action potential involved in contraction

PMID:10219239

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071805

potassium ion transmembrane transport

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0097623

potassium ion export across plasma membrane

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0060307

regulation of ventricular cardiac muscle cell membrane repolarization

PMID:10219239

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0060306

regulation of membrane repolarization

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0044325

ion channel binding

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0035690

cellular response to drug

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0015459

potassium channel regulator activity

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:1990573

potassium ion import across plasma membrane

PMID:10219239

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

PMID:22180649

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000746)

Seeded From UniProt

complete

protected

part_of

GO:0008076

voltage-gated potassium channel complex

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

contributes_to

GO:0005251

delayed rectifier potassium channel activity

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

contributes_to

GO:0005242

inward rectifier potassium channel activity

PMID:10219239

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:16780588

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005764

lysosome

PMID:16780588

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

contributes_to

GO:1902282

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001445835
UniProtKB:P15382

F

Seeded From UniProt

complete

protected

involved_in

GO:1902260

negative regulation of delayed rectifier potassium channel activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001445835
RGD:2956
RGD:621383
RGD:621384
UniProtKB:P15382
UniProtKB:Q9Y6H6
UniProtKB:Q9Y6J6

P

Seeded From UniProt

complete

protected

involved_in

GO:0097623

potassium ion export across plasma membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001445835
UniProtKB:Q9Y6J6

P

Seeded From UniProt

complete

protected

involved_in

GO:0086091

regulation of heart rate by cardiac conduction

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96673
PANTHER:PTN001445835
UniProtKB:P15382
UniProtKB:Q9UJ90
UniProtKB:Q9Y6H6
UniProtKB:Q9Y6J6

P

Seeded From UniProt

complete

protected

involved_in

GO:0086011

membrane repolarization during action potential

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001445835
RGD:621383
UniProtKB:P15382
UniProtKB:Q9UJ90
UniProtKB:Q9Y6J6

P

Seeded From UniProt

complete

protected

involved_in

GO:0086005

ventricular cardiac muscle cell action potential

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1891123
PANTHER:PTN001445835
UniProtKB:P15382
UniProtKB:Q9UJ90
UniProtKB:Q9Y6J6

P

Seeded From UniProt

complete

protected

involved_in

GO:0060307

regulation of ventricular cardiac muscle cell membrane repolarization

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1891123
PANTHER:PTN001445835
UniProtKB:P15382
UniProtKB:Q9UJ90
UniProtKB:Q9Y6H6
UniProtKB:Q9Y6J6

P

Seeded From UniProt

complete

protected

enables

GO:0044325

ion channel binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001445835
RGD:2956
RGD:621383
RGD:621384
UniProtKB:Q8WWG9
UniProtKB:Q9UJ90
UniProtKB:Q9Y6J6

F

Seeded From UniProt

complete

protected

enables

GO:0015459

potassium channel regulator activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96673
PANTHER:PTN001445835
RGD:2956
RGD:621383
RGD:621384
UniProtKB:P15382
UniProtKB:Q9UJ90
UniProtKB:Q9Y6H6
UniProtKB:Q9Y6J6

F

Seeded From UniProt

complete

protected

colocalizes_with

GO:0008076

voltage-gated potassium channel complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001445835
RGD:2956
RGD:621383
RGD:621384
UniProtKB:P15382
UniProtKB:Q9Y6H6
UniProtKB:Q9Y6J6

C

Seeded From UniProt

complete

protected

contributes_to

GO:0005251

delayed rectifier potassium channel activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001445835
RGD:621383
UniProtKB:P15382
UniProtKB:Q9Y6J6

F

Seeded From UniProt

complete

protected

involved_in

GO:1990573

potassium ion import across plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

involved_in

GO:1903817

negative regulation of voltage-gated potassium channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

involved_in

GO:1902260

negative regulation of delayed rectifier potassium channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

involved_in

GO:1902259

regulation of delayed rectifier potassium channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

involved_in

GO:1902159

regulation of cyclic nucleotide-gated ion channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

involved_in

GO:1901979

regulation of inward rectifier potassium channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

involved_in

GO:1901387

positive regulation of voltage-gated calcium channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

involved_in

GO:1901379

regulation of potassium ion transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

involved_in

GO:0097623

potassium ion export across plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

involved_in

GO:0086011

membrane repolarization during action potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

involved_in

GO:0086009

membrane repolarization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

involved_in

GO:0071805

potassium ion transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

involved_in

GO:0060306

regulation of membrane repolarization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

enables

GO:0044325

ion channel binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

F

Seeded From UniProt

complete

protected

involved_in

GO:0043586

tongue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

F

Seeded From UniProt

complete

protected

involved_in

GO:0035690

cellular response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

C

Seeded From UniProt

complete

protected

enables

GO:0015459

potassium channel regulator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

F

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

C

Seeded From UniProt

complete

protected

part_of

GO:0008076

voltage-gated potassium channel complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

C

Seeded From UniProt

complete

protected

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

C

Seeded From UniProt

complete

protected

part_of

GO:0005794

Golgi apparatus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

C

Seeded From UniProt

complete

protected

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

C

Seeded From UniProt

complete

protected

enables

GO:0005251

delayed rectifier potassium channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

F

Seeded From UniProt

complete

protected

enables

GO:0005249

voltage-gated potassium channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

F

Seeded From UniProt

complete

protected

enables

GO:0005242

inward rectifier potassium channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63161
ensembl:ENSRNOP00000045279

F

Seeded From UniProt

complete

protected

enables

GO:0005249

voltage-gated potassium channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000369
InterPro:IPR005425

F

Seeded From UniProt

complete

protected

involved_in

GO:0006811

ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000369

P

Seeded From UniProt

complete

protected

involved_in

GO:0006813

potassium ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005425

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000369
InterPro:IPR005425

C

Seeded From UniProt

complete

protected

part_of

GO:0008076

voltage-gated potassium channel complex

PMID:10219239

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0061337

cardiac conduction

Reactome:R-HSA-5576893
Reactome:R-HSA-5576890

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-5577237
Reactome:R-HSA-5577050

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

protected

enables

GO:0005244

voltage-gated ion channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0851

F

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

protected

involved_in

GO:0034765

regulation of ion transmembrane transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0851

P

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

protected

involved_in

GO:0071805

potassium ion transmembrane transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0631

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

enables

GO:0005267

potassium channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0631

F

Seeded From UniProt

complete

protected

involved_in

GO:0006813

potassium ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0633

P

Seeded From UniProt

complete



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