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HUMAN:ANM5

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0005737

cytoplasm

PMID:22952863

ECO:0000314

C

Figure 1 shows PRMT5 localized in the cytoplasm

complete
CACAO 7853

protected

enables

GO:0008168

methyltransferase activity

PMID:19011621

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0002039

p53 binding

PMID:19011621

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:21081503

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21081503

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:1904992

positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway

PMID:26554819

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P14416

P

Seeded From UniProt

complete

protected

enables

GO:0016274

protein-arginine N-methyltransferase activity

PMID:26554819

ECO:0000314

direct assay evidence used in manual assertion

F

has_input:(UniProtKB:P14416)

Seeded From UniProt

complete

protected

involved_in

GO:0035246

peptidyl-arginine N-methylation

PMID:26554819

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0044020

histone methyltransferase activity (H4-R3 specific)

PMID:25284789

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0034709

methylosome

PMID:25284789

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0008327

methyl-CpG binding

PMID:25284789

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0006353

DNA-templated transcription, termination

PMID:26700805

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0035097

histone methyltransferase complex

PMID:23048031

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0090161

Golgi ribbon formation

PMID:20421892

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0016274

protein-arginine N-methyltransferase activity

PMID:20421892

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005794

Golgi apparatus

PMID:20421892

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:22952863

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0003714

transcription corepressor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8CIG8

F

Seeded From UniProt

complete

protected

enables

GO:0070888

E-box binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8CIG8

F

Seeded From UniProt

complete

protected

involved_in

GO:0043985

histone H4-R3 methylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8CIG8

P

Seeded From UniProt

complete

protected

involved_in

GO:0032922

circadian regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8CIG8

P

Seeded From UniProt

complete

protected

involved_in

GO:0043985

histone H4-R3 methylation

PMID:18404153

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0043021

ribonucleoprotein complex binding

PMID:17709427

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P62318

F

Seeded From UniProt

complete

protected

involved_in

GO:0042118

endothelial cell activation

PMID:22269951

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0035243

protein-arginine omega-N symmetric methyltransferase activity

PMID:17709427

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0034709

methylosome

PMID:18984161

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0018216

peptidyl-arginine methylation

PMID:17709427

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:18984161

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:18404153

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0000387

spliceosomal snRNP assembly

PMID:17709427

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034969

histone arginine methylation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000077429
WB:WBGene00016408

P

Seeded From UniProt

complete

protected

enables

GO:0008469

histone-arginine N-methyltransferase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000077429
UniProtKB:Q5BH46
WB:WBGene00016408

F

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000077429
TAIR:locus:2126276
UniProtKB:O14744

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1351645
PANTHER:PTN000077429
PomBase:SPBC16H5.11c
UniProtKB:O14744
WB:WBGene00016408

C

Seeded From UniProt

complete

protected

enables

GO:0035243

protein-arginine omega-N symmetric methyltransferase activity

PMID:19011621

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0046982

protein heterodimerization activity

PMID:18495660

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0035246

peptidyl-arginine N-methylation

PMID:15369763

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008168

methyltransferase activity

PMID:15369763

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:23071334

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14744

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:22365833

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14744

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:11756452

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14744

F

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0019918

peptidyl-arginine methylation, to symmetrical-dimethyl arginine

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0035243

P

Seeded From UniProt

complete

protected

involved_in

GO:0019918

peptidyl-arginine methylation, to symmetrical-dimethyl arginine

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0035243

P

Seeded From UniProt

complete

protected

involved_in

GO:1903507

negative regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003714

P

Seeded From UniProt

complete

protected

involved_in

GO:0097421

liver regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A0E8
ensembl:ENSRNOP00000016302

P

Seeded From UniProt

complete

protected

involved_in

GO:0070372

regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A0E8
ensembl:ENSRNOP00000016302

P

Seeded From UniProt

complete

protected

involved_in

GO:0048714

positive regulation of oligodendrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A0E8
ensembl:ENSRNOP00000016302

P

Seeded From UniProt

complete

protected

involved_in

GO:0045596

negative regulation of cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A0E8
ensembl:ENSRNOP00000016302

P

Seeded From UniProt

complete

protected

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A0E8
ensembl:ENSRNOP00000016302

F

Seeded From UniProt

complete

protected

involved_in

GO:0044030

regulation of DNA methylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A0E8
ensembl:ENSRNOP00000016302

P

Seeded From UniProt

complete

protected

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A0E8
ensembl:ENSRNOP00000016302

C

Seeded From UniProt

complete

protected

involved_in

GO:0006479

protein methylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A0E8
ensembl:ENSRNOP00000016302

P

Seeded From UniProt

complete

protected

involved_in

GO:0006479

protein methylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007857
InterPro:IPR025799

P

Seeded From UniProt

complete

protected

enables

GO:0008168

methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007857
InterPro:IPR025799

F

Seeded From UniProt

complete

protected

involved_in

GO:0035246

peptidyl-arginine N-methylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007857

P

Seeded From UniProt

complete

protected

involved_in

GO:0007088

regulation of mitotic nuclear division

PMID:9843966

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008469

histone-arginine N-methyltransferase activity

Reactome:R-HSA-5661117
Reactome:R-HSA-5216234
Reactome:R-HSA-5205861
Reactome:R-HSA-5205799

ECO:0000304

author statement supported by traceable reference used in manual assertion




F

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-HSA-191790

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6804383
Reactome:R-HSA-6804379
Reactome:R-HSA-5661117
Reactome:R-HSA-5218952
Reactome:R-HSA-5216234
Reactome:R-HSA-5205861
Reactome:R-HSA-5205799
Reactome:R-HSA-3215448
Reactome:R-HSA-3215426
Reactome:R-HSA-3215406
Reactome:R-HSA-3215391
Reactome:R-HSA-3215385

ECO:0000304

author statement supported by traceable reference used in manual assertion












C

Seeded From UniProt

complete

protected

involved_in

GO:0000387

spliceosomal snRNP assembly

Reactome:R-HSA-191790

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

protected

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

protected

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

protected

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete



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