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ACACA:G8IIS4

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0030414

peptidase inhibitor activity

PMID:23397569

ECO:0000314

F

Figure 1B and 1C show that the cysteine protease inhibitor inhibited human cathepsin L, human cathepsin B, and papain enzymes. All of these enzymes are part of the C1 family of cysteine proteinases, therefore showing that the cysteine protease inhibitor inhibits protease, or peptidase, activity.

complete
CACAO 7629

public

GO:0005764

lysosome

PMID:23397569

ECO:0000314

C

Figure two shows that the cysteine protease inhibitor, originally located in the cytoplasm, localizes to the lysosome during cyst formation.

complete
CACAO 7632

protected

part_of

GO:0005764

lysosome

PMID:23397569

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0030414

peptidase inhibitor activity

PMID:23397569

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0010466

negative regulation of peptidase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030414

P

Seeded From UniProt

complete

protected

involved_in

GO:0010951

negative regulation of endopeptidase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004869

P

Seeded From UniProt

complete

protected

involved_in

GO:0010951

negative regulation of endopeptidase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004866

P

Seeded From UniProt

complete

protected

enables

GO:0004866

endopeptidase inhibitor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001713

F

Seeded From UniProt

complete

protected

enables

GO:0004869

cysteine-type endopeptidase inhibitor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000010

F

Seeded From UniProt

complete

protected

enables

GO:0008233

peptidase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

protected

involved_in

GO:0006508

proteolysis

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete




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