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Kanno, Y, Kuroki, A, Okada, K, Tomogane, K, Ueshima, S, Matsuo, O and Matsuno, H (2007) Alpha2-antiplasmin is involved in the production of transforming growth factor beta1 and fibrosis. J. Thromb. Haemost. 5:2266-73
Fibrotic disease occurs in most tissues. Transforming growth factor (TGF)-beta is the major inducer of fibrosis. The fibrinolytic system is considered to play an important role in the degradation of extracellular matrices. However, the detailed mechanism of how this system affects fibrosis remains unclear.
Animals; Bleomycin; Cells, Cultured; Fibroblasts/pathology; Fibrosis/etiology; Fibrosis/pathology; Mice; Transforming Growth Factor beta1/biosynthesis; alpha-2-Antiplasmin/deficiency; alpha-2-Antiplasmin/physiology