GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search


You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor


Yamashita, M, Kuwahara, M, Suzuki, A, Hirahara, K, Shinnaksu, R, Hosokawa, H, Hasegawa, A, Motohashi, S, Iwama, A and Nakayama, T (2008) Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J. Exp. Med. 205:1109-20


The maintenance of memory T cells is central to the establishment of immunological memory, although molecular details of the process are poorly understood. In the absence of the polycomb group (PcG) gene Bmi1, the number of memory CD4(+) T helper (Th)1/Th2 cells was reduced significantly. Enhanced cell death of Bmi1(-/-) memory Th2 cells was observed both in vivo and in vitro. Among various proapoptotic genes that are regulated by Bmi1, the expression of proapoptotic BH3-only protein Noxa was increased in Bmi1(-/-) effector Th1/Th2 cells. The generation of memory Th2 cells was restored by the deletion of Noxa, but not by Ink4a and Arf. Direct binding of Bmi1 to the Noxa gene locus was accompanied by histone H3-K27 methylation. The recruitment of other PcG gene products and Dnmt1 to the Noxa gene was highly dependent on the expression of Bmi1. In addition, Bmi1 was required for DNA CpG methylation of the Noxa gene. Moreover, memory Th2-dependent airway inflammation was attenuated substantially in the absence of Bmi1. Thus, Bmi1 controls memory CD4(+) Th1/Th2 cell survival and function through the direct repression of the Noxa gene.


PubMed PMC2373843 Online version:10.1084/jem.20072000


Animals; CD4-Positive T-Lymphocytes/immunology; Crosses, Genetic; DNA/genetics; Female; Gene Expression Regulation; Immunologic Memory; Lentivirus Infections/genetics; Lentivirus Infections/immunology; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Nuclear Proteins/deficiency; Nuclear Proteins/genetics; Proto-Oncogene Proteins/deficiency; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-bcl-2/deficiency; Proto-Oncogene Proteins c-bcl-2/genetics; Repressor Proteins/genetics; Th1 Cells/immunology; Th2 Cells/immunology