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Saitoh, T and Katoh, M (2001) Molecular cloning and characterization of human WNT8A. Int. J. Oncol. 19:123-7
WNT - beta-catenin - TCF pathway is involved in carcinogenesis and fetal development. Xenopus wnt-8 is one of the most potent Wnts with the capacity to activate beta-catenin - TCF pathway in the Xenopus axis duplication assay. Here, we have cloned and characterized WNT8A, a novel human homologue of Xenopus wnt-8. The WNT8A gene, consisting of at least 6 exons, was found to encode a 351-amino-acid polypeptide with the N-terminal signal peptide, three N-linked glycosylation sites, and conserved amino-acid residues of the WNT family. WNT8A showed 63.2% total-amino-acid identity to WNT8B. C-terminal region of WNT8A, WNT8B, WNT2, WNT2B1 and WNT2B2 were longer than that of other WNTs. Among various normal human tissues and 34 human cancer cells lines, the 3.5-kb WNT8A mRNA was detected only in a human teratocarcinoma cell line NT2. These results strongly suggest that WNT8A might be implicated in development of early embryos as well as germ cell tumors through activation of the WNT - beta-catenin - TCF pathway.
Amino Acid Sequence; Blotting, Northern; Cloning, Molecular; Cytoskeletal Proteins/metabolism; DNA Primers/chemistry; DNA, Complementary/genetics; DNA-Binding Proteins/metabolism; Gene Expression; Gene Library; Genomic Library; Humans; Lymphoid Enhancer-Binding Factor 1; Molecular Sequence Data; Neoplasms, Germ Cell and Embryonal/genetics; Neoplasms, Germ Cell and Embryonal/metabolism; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; RNA, Messenger/analysis; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Teratocarcinoma/genetics; Teratocarcinoma/metabolism; Trans-Activators; Transcription Factors/metabolism; Wnt Proteins; Wnt2 Protein; Zebrafish Proteins; beta Catenin