GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

TableEdit

Jump to: navigation, search

PMID:18604198

You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor

Citation

Kim, E, Goraksha-Hicks, P, Li, L, Neufeld, TP and Guan, KL (2008) Regulation of TORC1 by Rag GTPases in nutrient response. Nat. Cell Biol. 10:935-45

Abstract

TORC1 (target of rapamycin complex 1) has a crucial role in the regulation of cell growth and size. A wide range of signals, including amino acids, is known to activate TORC1. Here, we report the identification of Rag GTPases as activators of TORC1 in response to amino acid signals. Knockdown of Rag gene expression suppressed the stimulatory effect of amino acids on TORC1 in Drosophila melanogaster S2 cells. Expression of constitutively active (GTP-bound) Rag in mammalian cells activated TORC1 in the absence of amino acids, whereas expression of dominant-negative Rag blocked the stimulatory effects of amino acids on TORC1. Genetic studies in Drosophila also show that Rag GTPases regulate cell growth, autophagy and animal viability during starvation. Our studies establish a function of Rag GTPases in TORC1 activation in response to amino acid signals.

Links

PubMed PMC2711503 Online version:10.1038/ncb1753

Keywords

Amino Acids/pharmacology; Animals; Autophagy; Cell Line; Cell Proliferation; Cell Size; Drosophila Proteins/genetics; Drosophila melanogaster; Food; Humans; Monomeric GTP-Binding Proteins/physiology; Phosphatidylinositol 3-Kinases/genetics; Protein Kinases; RNA, Small Interfering/pharmacology; Signal Transduction

public



Cancel