GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:21677284
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
| Citation |
Abbas, A, Imrie, H, Viswambharan, H, Sukumar, P, Rajwani, A, Cubbon, RM, Gage, M, Smith, J, Galloway, S, Yuldeshava, N, Kahn, M, Xuan, S, Grant, PJ, Channon, KM, Beech, DJ, Wheatcroft, SB and Kearney, MT (2011) The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes 60:2169-78 |
|---|---|
| Abstract |
In mice, haploinsufficiency of the IGF-1 receptor (IGF-1R(+/-)), at a whole-body level, increases resistance to inflammation and oxidative stress, but the underlying mechanisms are unclear. We hypothesized that by forming insulin-resistant heterodimers composed of one IGF-1Rαβ and one insulin receptor (IR), IRαβ complex in endothelial cells (ECs), IGF-1R reduces free IR, which reduces EC insulin sensitivity and generation of the antioxidant/anti-inflammatory signaling radical nitric oxide (NO). |
| Links |
PubMed PMC3142083 Online version:10.2337/db11-0197 |
| Keywords |
Animals; Aorta/drug effects; Biological Availability; Down-Regulation; Endothelial Cells/metabolism; Glucose/metabolism; Glucose Intolerance/genetics; Humans; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Nitric Oxide/metabolism; Nitric Oxide Synthase Type III/metabolism; Phenylephrine/pharmacology; Receptor, IGF Type 1/deficiency; Receptor, IGF Type 1/genetics; Receptor, IGF Type 1/physiology; Receptor, Insulin/genetics; Receptor, Insulin/physiology; Signal Transduction; Umbilical Veins/cytology; Vasoconstriction/drug effects |
| public |
| Cancel |
