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TableEdit
HUMAN:SMAD4
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Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status | |
---|---|---|---|---|---|---|---|---|---|---|---|
public |
GO:0035556 |
intracellular signal transduction |
PMID:22316667 |
ECO:0000315 |
P |
SMAD4 Mutations result in in disruption of BMP signaling. Using samples obtained from human JP samples, followed by PCR & SDM, mutants activity (as assayed by Luciferase, see Figure 1) was much lower then WT, confirming the hypothesis of mutated SMAD signaling being a key component of JP patients. |
complete | ||||
protected |
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
PMID:25514493 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
PMID:19274049 |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
PMID:19274049 |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
InterPro:IPR001132 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0060956 |
endocardial cell differentiation |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0036302 |
atrioventricular canal development |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0003251 |
positive regulation of cell proliferation involved in heart valve morphogenesis |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0003190 |
atrioventricular valve formation |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_REF:0000113 |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
UniProtKB:P97454 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:1905305 |
negative regulation of cardiac myofibril assembly |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0042802 |
identical protein binding |
PMID:10647180 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0043199 |
sulfate binding |
PMID:10647180 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0071141 |
SMAD protein complex |
PMID:10647180 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0070207 |
protein homotrimerization |
PMID:10647180 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
|
Seeded From UniProt |
complete |
protected |
involved_in |
GO:0060412 |
ventricular septum morphogenesis |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0010614 |
negative regulation of cardiac muscle hypertrophy |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0003148 |
outflow tract septum morphogenesis |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0003220 |
left ventricular cardiac muscle tissue morphogenesis |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
|
Seeded From UniProt |
complete |
protected |
involved_in |
GO:0006879 |
cellular iron ion homeostasis |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0071773 |
cellular response to BMP stimulus |
PMID:14687659 |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0030509 |
BMP signaling pathway |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
occurs_in:(CL:0000182) |
Seeded From UniProt |
complete |
protected |
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
|
Seeded From UniProt |
complete |
protected |
involved_in |
GO:2000617 |
positive regulation of histone H3-K9 acetylation |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0070102 |
interleukin-6-mediated signaling pathway |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0051571 |
positive regulation of histone H3-K4 methylation |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
|
Seeded From UniProt |
complete |
protected |
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
occurs_in:(CL:0000182) |
Seeded From UniProt |
complete |
protected |
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
|
Seeded From UniProt |
complete |
protected |
part_of |
GO:0005634 |
nucleus |
PMID:16007207 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
PMID:9389648 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
PMID:9389648 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
PMID:9389648 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0035556 |
intracellular signal transduction |
PMID:22316667 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0070412 |
R-SMAD binding |
PMID:9732876 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:P84022 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0070412 |
R-SMAD binding |
PMID:9111321 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:Q15797 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0070412 |
R-SMAD binding |
PMID:9111321 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:Q15796 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0070412 |
R-SMAD binding |
PMID:9111321 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:P84022 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0070412 |
R-SMAD binding |
PMID:9311995 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:Q15796 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0070412 |
R-SMAD binding |
PMID:9311995 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:P84022 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0070412 |
R-SMAD binding |
PMID:8774881 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:P84022 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0070411 |
I-SMAD binding |
PMID:9256479 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:O43541 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0060395 |
SMAD protein signal transduction |
PMID:9707553 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0060395 |
SMAD protein signal transduction |
PMID:9732876 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0060391 |
positive regulation of SMAD protein signal transduction |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0062009 |
secondary palate development |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
PMID:9732876 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
PMID:9389648 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
PMID:9311995 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
PMID:8774881 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
PMID:8774881 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0044212 |
transcription regulatory region DNA binding |
PMID:17438144 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
contributes_to |
GO:0043565 |
sequence-specific DNA binding |
PMID:10823886 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0042803 |
protein homodimerization activity |
PMID:8774881 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:Q13485 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0042802 |
identical protein binding |
PMID:9111321 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:Q13485 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0032909 |
regulation of transforming growth factor beta2 production |
PMID:12411310 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0032444 |
activin responsive factor complex |
PMID:9389648 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0030616 |
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity |
PMID:9389648 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0030513 |
positive regulation of BMP signaling pathway |
PMID:19366699 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0030511 |
positive regulation of transforming growth factor beta receptor signaling pathway |
PMID:19328798 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0030509 |
BMP signaling pathway |
PMID:9389648 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0030308 |
negative regulation of cell growth |
PMID:8774881 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
PMID:8774881 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0010718 |
positive regulation of epithelial to mesenchymal transition |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007183 |
SMAD protein complex assembly |
PMID:10823886 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
PMID:9732876 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
PMID:9389648 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005737 |
cytoplasm |
PMID:9389648 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005737 |
cytoplasm |
PMID:9311995 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005737 |
cytoplasm |
PMID:12161428 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005667 |
transcription factor complex |
PMID:17438144 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005634 |
nucleus |
PMID:9389648 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005634 |
nucleus |
PMID:9311995 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005634 |
nucleus |
PMID:12161428 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
contributes_to |
GO:0003700 |
DNA-binding transcription factor activity |
PMID:17438144 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
contributes_to |
GO:0003700 |
DNA-binding transcription factor activity |
PMID:10823886 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
contributes_to |
GO:0003677 |
DNA binding |
PMID:9389648 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0001666 |
response to hypoxia |
PMID:12411310 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0000790 |
nuclear chromatin |
PMID:21828274 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0000925)|part_of:(CL:0002322) |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0071559 |
response to transforming growth factor beta |
PMID:9707553 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0071141 |
SMAD protein complex |
PMID:18832382 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
PMID:18832382 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
PMID:9707553 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005667 |
transcription factor complex |
PMID:12374795 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:Q8JIT7 |
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005667 |
transcription factor complex |
PMID:12374795 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:P70056 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003712 |
transcription coregulator activity |
PMID:18832382 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0000987 |
proximal promoter sequence-specific DNA binding |
PMID:18832382 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0042802 |
identical protein binding |
PMID:25609649 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:Q13485 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0042802 |
identical protein binding |
PMID:21988832 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:Q13485 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005829 |
cytosol |
GO_REF:0000052 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005813 |
centrosome |
GO_REF:0000052 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005654 |
nucleoplasm |
GO_REF:0000052 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:2000617 |
positive regulation of histone H3-K9 acetylation |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:1905305 |
negative regulation of cardiac myofibril assembly |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0090575 |
RNA polymerase II transcription factor complex |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0072520 |
seminiferous tubule development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0072134 |
nephrogenic mesenchyme morphogenesis |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0072133 |
metanephric mesenchyme morphogenesis |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0070102 |
interleukin-6-mediated signaling pathway |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0062009 |
secondary palate development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0061614 |
pri-miRNA transcription by RNA polymerase II |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0061040 |
female gonad morphogenesis |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0060956 |
endocardial cell differentiation |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0060548 |
negative regulation of cell death |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0060412 |
ventricular septum morphogenesis |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0060391 |
positive regulation of SMAD protein signal transduction |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0060065 |
uterus development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0051797 |
regulation of hair follicle development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0051571 |
positive regulation of histone H3-K4 methylation |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0051098 |
regulation of binding |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0048859 |
formation of anatomical boundary |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0048733 |
sebaceous gland development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0048729 |
tissue morphogenesis |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0048663 |
neuron fate commitment |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0048589 |
developmental growth |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0046982 |
protein heterodimerization activity |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0046881 |
positive regulation of follicle-stimulating hormone secretion |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0042803 |
protein homodimerization activity |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0042733 |
embryonic digit morphogenesis |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0042127 |
regulation of cell population proliferation |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0042118 |
endothelial cell activation |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0036302 |
atrioventricular canal development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0033686 |
positive regulation of luteinizing hormone secretion |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0032525 |
somite rostral/caudal axis specification |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0030509 |
BMP signaling pathway |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0014033 |
neural crest cell differentiation |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0010718 |
positive regulation of epithelial to mesenchymal transition |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0010614 |
negative regulation of cardiac muscle hypertrophy |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0009952 |
anterior/posterior pattern specification |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0008585 |
female gonad development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0008584 |
male gonad development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0008283 |
cell population proliferation |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007498 |
mesoderm development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007492 |
endoderm development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007411 |
axon guidance |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007369 |
gastrulation |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007338 |
single fertilization |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007283 |
spermatogenesis |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0006879 |
cellular iron ion homeostasis |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005737 |
cytoplasm |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005667 |
transcription factor complex |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005634 |
nucleus |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0005518 |
collagen binding |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003700 |
DNA-binding transcription factor activity |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003682 |
chromatin binding |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003677 |
DNA binding |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0003360 |
brainstem development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0003279 |
cardiac septum development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0003251 |
positive regulation of cell proliferation involved in heart valve morphogenesis |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0003220 |
left ventricular cardiac muscle tissue morphogenesis |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0003198 |
epithelial to mesenchymal transition involved in endocardial cushion formation |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0003190 |
atrioventricular valve formation |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0003148 |
outflow tract septum morphogenesis |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0001822 |
kidney development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0001702 |
gastrulation with mouth forming second |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0001701 |
in utero embryonic development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0001658 |
branching involved in ureteric bud morphogenesis |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0001541 |
ovarian follicle development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0001085 |
RNA polymerase II transcription factor binding |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97471 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003700 |
DNA-binding transcription factor activity |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR013019 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005667 |
transcription factor complex |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR013019 |
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001132 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR013019 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:1901522 |
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
PMID:14687659 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
part_of:(GO:0071773) |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
Reactome:R-HSA-2173796 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0035019 |
somatic stem cell population maintenance |
Reactome:R-HSA-452723 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0030509 |
BMP signaling pathway |
Reactome:R-HSA-201451 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0016579 |
protein deubiquitination |
Reactome:R-HSA-5688426 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
Reactome:R-HSA-2173789 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-870479 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-NUL-9625758 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
Reactome:R-HSA-2173795 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005737 |
cytoplasm |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0963 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0046872 |
metal ion binding |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0479 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005634 |
nucleus |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0539 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003677 |
DNA binding |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0238 |
F |
Seeded From UniProt |
complete |
Cancel |