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YEAST:VMS1
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | VMS1 | |
| Protein Name(s) | Protein VMS1
VCP/CDC48-associated mitochondrial stress-responsive protein 1 | |
| External Links | ||
| UniProt | Q04311 | |
| EMBL | Z49209 AY723770 BK006938 | |
| PIR | S54034 | |
| RefSeq | NP_010334.1 | |
| PDB | 5WHG | |
| PDBsum | 5WHG | |
| ProteinModelPortal | Q04311 | |
| SMR | Q04311 | |
| BioGrid | 32103 | |
| DIP | DIP-6303N | |
| IntAct | Q04311 | |
| MINT | Q04311 | |
| STRING | 4932.YDR049W | |
| iPTMnet | Q04311 | |
| MaxQB | Q04311 | |
| PaxDb | Q04311 | |
| PRIDE | Q04311 | |
| EnsemblFungi | YDR049W | |
| GeneID | 851618 | |
| KEGG | sce:YDR049W | |
| EuPathDB | FungiDB:YDR049W | |
| SGD | S000002456 | |
| GeneTree | ENSGT00390000005911 | |
| InParanoid | Q04311 | |
| OMA | SFCSTRC | |
| OrthoDB | EOG092C2EXB | |
| BioCyc | YEAST:G3O-29660-MONOMER | |
| PRO | PR:Q04311 | |
| Proteomes | UP000002311 | |
| GO | GO:0036266 GO:0005829 GO:0005789 GO:0005739 GO:0046872 GO:0003676 GO:0072671 GO:0071630 GO:0030433 | |
| Gene3D | 1.25.40.20 | |
| InterPro | IPR036770 IPR013087 | |
| SUPFAM | SSF48403 | |
| PROSITE | PS00028 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0004843 |
thiol-dependent ubiquitin-specific protease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072671 |
mitochondria-associated ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071630 |
nuclear protein quality control by the ubiquitin-proteasome system |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0036266 |
Cdc48p-Npl4p-Vms1p AAA ATPase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030433 |
ubiquitin-dependent ERAD pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0005840 |
ribosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004045 |
aminoacyl-tRNA hydrolase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072671 |
mitochondria-associated ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000411325 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071630 |
nuclear protein quality control by the ubiquitin-proteasome system |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000411325 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0036266 |
Cdc48p-Npl4p-Vms1p AAA ATPase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000411325 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030433 |
ubiquitin-dependent ERAD pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000411325 |
P |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0004843 |
thiol-dependent ubiquitin-specific protease activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000411325 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
- ↑ Sickmann, A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. U.S.A. 100 13207-12 PubMed GONUTS page
- ↑ Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
- ↑ Tran, JR & Brodsky, JL (2014) The Cdc48-Vms1 complex maintains 26S proteasome architecture. Biochem. J. 458 459-67 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Heo, JM et al. (2010) A stress-responsive system for mitochondrial protein degradation. Mol. Cell 40 465-80 PubMed GONUTS page
- ↑ Baek, GH et al. (2012) The Cdc48 protein and its cofactor Vms1 are involved in Cdc13 protein degradation. J. Biol. Chem. 287 26788-95 PubMed GONUTS page
- ↑ 7.0 7.1 Tran, JR et al. (2011) A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis. J. Biol. Chem. 286 5744-55 PubMed GONUTS page
- ↑ 8.0 8.1 Verma, R et al. (2018) Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes. Nature 557 446-451 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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