MOUSE:LYAM3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Selp (synonyms: Grmp)
Protein Name(s)	P-selectin CD62 antigen-like family member P Granule membrane protein 140 GMP-140 Leukocyte-endothelial cell adhesion molecule 3 LECAM3 Platelet activation dependent granule-external membrane protein PADGEM
External Links
UniProt	Q01102
EMBL	M87861 M72332 BC109158 BC109159
CCDS	CCDS48422.1
PIR	A42755
RefSeq	NP_035477.1
UniGene	Mm.3337
PDB	4GXB
PDBsum	4GXB
ProteinModelPortal	Q01102
SMR	Q01102
BindingDB	Q01102
ChEMBL	CHEMBL2455
PhosphoSite	Q01102
PRIDE	Q01102
Ensembl	ENSMUST00000162746
GeneID	20344
KEGG	mmu:20344
UCSC	uc007dhz.2
CTD	6403
MGI	MGI:98280
eggNOG	NOG242963
GeneTree	ENSGT00760000118803
HOGENOM	HOG000236254
HOVERGEN	HBG052375
InParanoid	Q01102
KO	K06496
OMA	TYGVFTN
OrthoDB	EOG7DZ8J9
PhylomeDB	Q01102
TreeFam	TF326910
Reactome	REACT_225233
NextBio	298177
PRO	PR:Q01102
Proteomes	UP000000589
Bgee	Q01102
CleanEx	MM_SELP
Genevestigator	Q01102
GO	GO:0009897 GO:0005615 GO:0016021 GO:0016020 GO:0005634 GO:0031092 GO:0048306 GO:0042806 GO:0001948 GO:0008201 GO:0001530 GO:0070492 GO:0033691 GO:0071354 GO:0007157 GO:0006954 GO:0007159 GO:0050900 GO:0050901 GO:0002687 GO:0014068 GO:0010572 GO:0033623
Gene3D	3.10.100.10
InterPro	IPR001304 IPR016186 IPR018378 IPR016187 IPR000742 IPR013032 IPR002396 IPR000436
Pfam	PF00008 PF00059 PF00084
PRINTS	PR00343
SMART	SM00032 SM00034 SM00181
SUPFAM	SSF56436 SSF57535
PROSITE	PS00615 PS50041 PS00022 PS01186 PS50026 PS50923

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16109	C		Seeded From UniProt	complete
enables	GO:0070492	oligosaccharide binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16109	F		Seeded From UniProt	complete
involved_in	GO:0050901	leukocyte tethering or rolling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16109	P		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16109	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16109	F		Seeded From UniProt	complete
involved_in	GO:0010572	positive regulation of platelet activation	PMID:16514062^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033623	regulation of integrin activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16109	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16109	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071354	cellular response to interleukin-6	PMID:9486531^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14242	P		Seeded From UniProt	complete
enables	GO:0070492	oligosaccharide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050901	leukocyte tethering or rolling	PMID:15956287^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857245	P	occurs_in:(EMAPA:17348) occurs_in:(CL:0000069)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050901	leukocyte tethering or rolling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050900	leukocyte migration	PMID:15484189^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857245	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050900	leukocyte migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3656	P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:7524641^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045785	positive regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3656	P		Seeded From UniProt	complete
enables	GO:0042806	fucose binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035584	calcium-mediated signaling using intracellular calcium source	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	P		Seeded From UniProt	complete
enables	GO:0033691	sialic acid binding	PMID:8562500^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0033691	sialic acid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033623	regulation of integrin activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	P		Seeded From UniProt	complete
part_of	GO:0031092	platelet alpha granule membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:7688665^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15956287^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17348) part_of:(CL:0000069)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:8562500^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000233)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:23583643^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:19349303^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000775)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:17114491^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16138)\|part_of:(EMAPA:16105)\|part_of:(EMAPA:16728)\|part_of:(EMAPA:18767)\|part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3656	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007159	leukocyte cell-cell adhesion	PMID:8562500^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007159	leukocyte cell-cell adhesion	PMID:8557754^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007159	leukocyte cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:8562500^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:8557754^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	PMID:7688665^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857245	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3656	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002691	regulation of cellular extravasation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002687	positive regulation of leukocyte migration	PMID:17114491^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98278	P	occurs_in:(EMAPA:16138) results_in_movement_of:(CL:0000738)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002687	positive regulation of leukocyte migration	PMID:17114491^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16138) results_in_movement_of:(CL:0000738)	Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16109	F		Seeded From UniProt	complete
enables	GO:0070492	oligosaccharide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	F		Seeded From UniProt	complete
involved_in	GO:0050901	leukocyte tethering or rolling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	P		Seeded From UniProt	complete
enables	GO:0042806	fucose binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	F		Seeded From UniProt	complete
involved_in	GO:0035584	calcium-mediated signaling using intracellular calcium source	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	P		Seeded From UniProt	complete
enables	GO:0033691	sialic acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	F		Seeded From UniProt	complete
involved_in	GO:0033623	regulation of integrin activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	P		Seeded From UniProt	complete
part_of	GO:0031092	platelet alpha granule membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	C		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	F		Seeded From UniProt	complete
involved_in	GO:0007159	leukocyte cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	F		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16109 ensembl:ENSP00000263686	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002396	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002396	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0430	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ståhl, AL et al. (2006) Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome. Blood 108 167-76 PubMed GONUTS page
↑ Peterson, RS et al. (1997) The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives. Mech. Dev. 69 53-69 PubMed GONUTS page
↑ ^3.0 ^3.1 Dole, VS et al. (2005) Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Blood 106 2334-9 PubMed GONUTS page
↑ Fernekorn, U et al. (2004) Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Eur. J. Immunol. 34 3423-33 PubMed GONUTS page
↑ Sammar, M et al. (1994) Heat-stable antigen (CD24) as ligand for mouse P-selectin. Int. Immunol. 6 1027-36 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Aigner, S et al. (1995) Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin. Int. Immunol. 7 1557-65 PubMed GONUTS page
↑ ^7.0 ^7.1 Mayadas, TN et al. (1993) Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 74 541-54 PubMed GONUTS page
↑ Vogel, KU et al. (2013) Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. Immunity 38 655-68 PubMed GONUTS page
↑ Stone, EL et al. (2009) Glycosyltransferase function in core 2-type protein O glycosylation. Mol. Cell. Biol. 29 3770-82 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Mullaly, SC & Kubes, P (2006) The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J. Immunol. 177 8154-63 PubMed GONUTS page
↑ ^11.0 ^11.1 Ruppert, M et al. (1995) The L1 adhesion molecule is a cellular ligand for VLA-5. J. Cell Biol. 131 1881-91 PubMed GONUTS page

[PMID:16514062-1] Ståhl, AL et al. (2006) Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome. Blood 108 167-76 PubMed GONUTS page

[PMID:9486531-2] Peterson, RS et al. (1997) The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives. Mech. Dev. 69 53-69 PubMed GONUTS page

[PMID:15956287-3] 3.0 ^3.1 Dole, VS et al. (2005) Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Blood 106 2334-9 PubMed GONUTS page

[PMID:15484189-4] Fernekorn, U et al. (2004) Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Eur. J. Immunol. 34 3423-33 PubMed GONUTS page

[PMID:7524641-5] Sammar, M et al. (1994) Heat-stable antigen (CD24) as ligand for mouse P-selectin. Int. Immunol. 6 1027-36 PubMed GONUTS page

[PMID:8562500-6] 6.0 ^6.1 ^6.2 ^6.3 Aigner, S et al. (1995) Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin. Int. Immunol. 7 1557-65 PubMed GONUTS page

[PMID:7688665-7] 7.0 ^7.1 Mayadas, TN et al. (1993) Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 74 541-54 PubMed GONUTS page

[PMID:23583643-8] Vogel, KU et al. (2013) Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. Immunity 38 655-68 PubMed GONUTS page

[PMID:19349303-9] Stone, EL et al. (2009) Glycosyltransferase function in core 2-type protein O glycosylation. Mol. Cell. Biol. 29 3770-82 PubMed GONUTS page

[PMID:17114491-10] 10.0 ^10.1 ^10.2 Mullaly, SC & Kubes, P (2006) The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J. Immunol. 177 8154-63 PubMed GONUTS page

[PMID:8557754-11] 11.0 ^11.1 Ruppert, M et al. (1995) The L1 adhesion molecule is a cellular ligand for VLA-5. J. Cell Biol. 131 1881-91 PubMed GONUTS page

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MOUSE:LYAM3

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