GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
KLEP7:HPXO
Contents
| Species (Taxon ID) | Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH78578). (272620) | |
| Gene Name(s) | hpxO | |
| Protein Name(s) | FAD-dependent urate hydroxylase | |
| External Links | ||
| UniProt | A6T923 | |
| EMBL | CP000647 | |
| RefSeq | YP_001335324.1 | |
| PDB | 3RP6 3RP7 3RP8 | |
| PDBsum | 3RP6 3RP7 3RP8 | |
| ProteinModelPortal | A6T923 | |
| STRING | 272620.KPN_01663 | |
| EnsemblBacteria | ABR77094 | |
| GeneID | 5340847 | |
| KEGG | kpn:KPN_01663 | |
| PATRIC | 20457612 | |
| eggNOG | COG0654 | |
| HOGENOM | HOG000166536 | |
| KO | K16839 | |
| OMA | NTTPDIG | |
| OrthoDB | EOG6TR0FF | |
| BioCyc | KPNE272620:GKDC-1663-MONOMER | |
| UniPathway | UPA00394 | |
| Proteomes | UP000000265 | |
| GO | GO:0071949 GO:0016709 GO:0006144 GO:0019628 | |
| InterPro | IPR002938 IPR003042 | |
| Pfam | PF01494 | |
| PRINTS | PR00420 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0071949 |
FAD binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0004846 |
urate oxidase activity |
ECO:0000314 |
F |
Figure 2, particularly following C thru E C - Control without the Hpxo enzyme D - Urate oxidation with the commercial oxidase E - Urate oxidation with Hpxo |
complete | |||||
|
enables |
GO:0004846 |
urate oxidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0071949 |
FAD binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019628 |
urate catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016709 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0071949 |
FAD binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102099 |
FAD-dependent urate hydroxylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006144 |
purine nucleobase metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019628 |
urate catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00394 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hicks, KA et al. (2013) Structural and mechanistic studies of HpxO, a novel flavin adenine dinucleotide-dependent urate oxidase from Klebsiella pneumoniae. Biochemistry 52 477-87 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 O'Leary, SE et al. (2009) Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase. Biochemistry 48 3033-5 PubMed GONUTS page
