HV1BR:TAT

Species (Taxon ID)	Human immunodeficiency virus type 1 group M subtype B (isolateBRU/LAI) (HIV-1). (11686)
Gene Name(s)	tat
Protein Name(s)	Protein Tat Transactivating regulatory protein
External Links
UniProt	P04610
EMBL	K02013 M19921
PIR	A25700
PDB	1JFW 1JM4
PDBsum	1JFW 1JM4
ProteinModelPortal	P04610
SMR	P04610
IntAct	P04610
MINT	MINT-7908963
EvolutionaryTrace	P04610
Proteomes	UP000007692
GO	GO:0030430 GO:0044196 GO:0046872 GO:0003723 GO:0003700 GO:0006915 GO:0060081 GO:0039525 GO:0039586 GO:0052312 GO:1901856 GO:0051092 GO:1900182 GO:0039502 GO:0006351
Gene3D	4.10.20.10
InterPro	IPR001831
Pfam	PF00539
PRINTS	PR00055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060081	membrane hyperpolarization	PMID:17202348	ECO:0000314			P		Figure 1 shows that adding tat protein to cortical neurons caused a 10% loss in rhod123 fluorescence which is a measurement method of mitochondrial membrane potential. This result proves that the tat protein induces mitochondrial hyperpolarization.	complete CACAO 6382
	GO:1901856	negative regulation of cellular respiration	PMID:17202348	ECO:0000314			P		Figure 3 demonstrates the inhibiting effect of the tat protein on mitochondrial complexes III and IV while having no effect on complexes I and II. The ETC activity of an isolated mitochondrial protein was monitored after adding tat protein, and the graph (A) shows the effect that the tat treatment had on each complex. Complexes III and IV show inhibited activity once the tat protein was introduced. (B) shows the concentration dependent inhibition of complex IV activity.	complete CACAO 6406
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:10400814	ECO:0000314			P		Figure 3B shows the gel retardation analysis of NF-kappaB complexes induced by Tat in both NIH 3T3 and PKR knockout mouse cells. The analysis reveals that neither the tat protein nor the PKR (a Cellular Interferon-Inducible, Double-Stranded RNA-Dependent Protein Kinase) can activate the NF-kappa-B transcription factor (lanes 1 and 2). When the tat protein and PKR worked together (Lane 3), this produced a positive activation of NF-kappaB. This proves that the tat protein must activate NF-kappaB through PKR.	complete CACAO 6522
	GO:0052312	modulation of transcription in other organism involved in symbiotic interaction	PMID:22593154	ECO:0000314			P		Figure 3A demonstrates that the Tat addition to Jurkat T cells caused a 10.8-fold increase in Human Endogenous Retrovirus Type-K (HML-2) gag RNA production after 6 hours. This concludes that the tat protein activates the expression of HML-2.	complete CACAO 6527
	GO:1900182	positive regulation of protein localization to nucleus	PMID:22219277	ECO:0000314			P		Figure 1C indicates that the tat protein triggers the ZO-1 protein localization to the nucleus. This is shown by significantly increased ZO-1 expression in the nucleus of adenovirus-infected hCMEC/D3 cells depicted in the bar graph in Figure 1C.	complete CACAO 6531
involved_in	GO:1901856	negative regulation of cellular respiration	PMID:17202348	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	PMID:22219277	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060081	membrane hyperpolarization	PMID:17202348	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0052312	modulation of transcription in other organism involved in symbiotic interaction	PMID:22593154	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:10400814	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001070	RNA-binding transcription regulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001831	F		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001831	C		Seeded From UniProt	complete
involved_in	GO:0050434	positive regulation of viral transcription	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001831	P		Seeded From UniProt	complete
involved_in	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	P		Seeded From UniProt	complete
enables	GO:0042805	actinin binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	F		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	F		Seeded From UniProt	complete
involved_in	GO:0050434	positive regulation of viral transcription	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	P		Seeded From UniProt	complete
involved_in	GO:0039502	suppression by virus of host type I interferon-mediated signaling pathway	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	P		Seeded From UniProt	complete
involved_in	GO:0039586	modulation by virus of host PP1 activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	P		Seeded From UniProt	complete
involved_in	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	P		Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	C		Seeded From UniProt	complete
part_of	GO:0044196	host cell nucleolus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	C		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	F		Seeded From UniProt	complete
involved_in	GO:0039525	modulation by virus of host chromatin organization	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	P		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	C		Seeded From UniProt	complete
enables	GO:0001070	RNA-binding transcription regulator activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	F		Seeded From UniProt	complete
enables	GO:1990970	trans-activation response element binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000613387	F		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
involved_in	GO:0039503	suppression by virus of host innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1090	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0039502	suppression by virus of host type I interferon-mediated signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1114	P		Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1035 UniProtKB-SubCell:SL-0381	C		Seeded From UniProt	complete
involved_in	GO:0030683	evasion or tolerance by virus of host immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0899	P		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048	C		Seeded From UniProt	complete
involved_in	GO:0039525	modulation by virus of host chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1122	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0039586	modulation by virus of host PP1 activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1126	P		Seeded From UniProt	complete
part_of	GO:0044196	host cell nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0412	C		Seeded From UniProt	complete
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