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HUMAN:UVRAG

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) UVRAG
Protein Name(s) UV radiation resistance-associated gene protein

p63

External Links
UniProt Q9P2Y5
EMBL X99050
AB012958
AK095352
AK296871
AK316133
AP002340
AP003031
AP003168
CCDS CCDS8241.1
RefSeq NP_003360.2
UniGene Hs.202470
ProteinModelPortal Q9P2Y5
BioGrid 113248
DIP DIP-48652N
IntAct Q9P2Y5
MINT MINT-4658044
STRING 9606.ENSP00000348455
PhosphoSite Q9P2Y5
DMDM 20140879
MaxQB Q9P2Y5
PaxDb Q9P2Y5
PRIDE Q9P2Y5
Ensembl ENST00000356136
ENST00000531818
ENST00000532130
ENST00000533454
GeneID 7405
KEGG hsa:7405
UCSC uc001oxc.3
uc001oxd.3
CTD 7405
GeneCards GC11P075526
HGNC HGNC:12640
HPA HPA016932
MIM 602493
neXtProt NX_Q9P2Y5
PharmGKB PA37264
eggNOG NOG285458
GeneTree ENSGT00390000012877
HOGENOM HOG000147825
HOVERGEN HBG059846
InParanoid Q9P2Y5
OMA LPGEFHP
OrthoDB EOG7NW68R
PhylomeDB Q9P2Y5
TreeFam TF323546
ChiTaRS UVRAG
GeneWiki UVRAG
GenomeRNAi 7405
NextBio 28992
PRO PR:Q9P2Y5
Proteomes UP000005640
Bgee Q9P2Y5
CleanEx HS_UVRAG
ExpressionAtlas Q9P2Y5
Genevestigator Q9P2Y5
GO GO:0005737
GO:0005769
GO:0005770
GO:0005764
GO:0045335
GO:0043234
GO:0006281
GO:0010508
GO:0035493
GO:0046718
Gene3D 2.60.40.150
InterPro IPR000008
IPR018791
Pfam PF10186
PF00168
SMART SM00239
SUPFAM SSF49562

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006914

autophagy

PMID:24056303[1]

ECO:0000315

P

According to Supplementary Figure 7 a and b, , it is shown that knockdown mutations of UVRAG resulted in the improper autophagy induced dispersal of fluorescent Atg9, compared to the even dispersal seen in the control.

complete
CACAO 9032

GO:0051684

maintenance of Golgi location

PMID:24056303[1]

ECO:0000315

P

In Figure 6b, it is shown that knockdown mutations of UVRAG result in the dispersion of cis Golgi, whereas it is maintained maintained in a discrete structure in the control.

complete
CACAO 9033

GO:0006890

retrograde vesicle-mediated transport, Golgi to ER

PMID:24056303[1]

ECO:0000315

P

Figure 5a shows that a knockdown mutation of UVRAG impairs the ability of a protein complex associated with retrograde transport, and in figure 5b it is shown that the same knockdown results in inhibition of retrograde transport from the Golgi to the ER.

complete
CACAO 9034

GO:0005783

endoplasmic reticulum

PMID:24056303[1]

ECO:0000314

C

According to the various colocalization assays in Figure 2, UVRAG is found in the same cellular location as marker proteins classically used to mark the ER.

complete
CACAO 9043

involved_in

GO:0097352

autophagosome maturation

PMID:28306502[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000421

autophagosome membrane

PMID:28306502[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030496

midbody

PMID:20643123[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032465

regulation of cytokinesis

PMID:20643123[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032801

receptor catabolic process

PMID:20643123[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:22542840[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097680

double-strand break repair via classical nonhomologous end joining

PMID:22542840[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071900

regulation of protein serine/threonine kinase activity

PMID:22542840[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0070418

DNA-dependent protein kinase complex

PMID:22542840[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:22542840[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007098

centrosome cycle

PMID:22542840[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:24056303[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006890

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

PMID:24056303[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051684

maintenance of Golgi location

PMID:24056303[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

PMID:24056303[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

PMID:19270696[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:19270696[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

PMID:19270696[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0035493

SNARE complex assembly

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1925860
PANTHER:PTN000389174

P

Seeded From UniProt

complete

enables

GO:0000149

SNARE binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1925860
PANTHER:PTN000389174

F

Seeded From UniProt

complete

involved_in

GO:0046718

viral entry into host cell

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K245
ensembl:ENSMUSP00000045297

P

Seeded From UniProt

complete

part_of

GO:0045335

phagocytic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K245
ensembl:ENSMUSP00000045297

C

Seeded From UniProt

complete

involved_in

GO:0035493

SNARE complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K245
ensembl:ENSMUSP00000045297

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K245
ensembl:ENSMUSP00000045297

C

Seeded From UniProt

complete

enables

GO:0017124

SH3 domain binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K245
ensembl:ENSMUSP00000045297

F

Seeded From UniProt

complete

involved_in

GO:0007098

centrosome cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K245
ensembl:ENSMUSP00000045297

P

Seeded From UniProt

complete

involved_in

GO:0007059

chromosome segregation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K245
ensembl:ENSMUSP00000045297

P

Seeded From UniProt

complete

involved_in

GO:0007051

spindle organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K245
ensembl:ENSMUSP00000045297

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K245
ensembl:ENSMUSP00000045297

P

Seeded From UniProt

complete

enables

GO:0000149

SNARE binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8K245
ensembl:ENSMUSP00000045297

F

Seeded From UniProt

complete

colocalizes_with

GO:0030897

HOPS complex

PMID:21118109[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1901098

positive regulation of autophagosome maturation

PMID:21118109[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071985

multivesicular body sorting pathway

PMID:21118109[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:9169138[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:9169138[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0458
UniProtKB-SubCell:SL-0158

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0137
UniProtKB-SubCell:SL-0047

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0094

C

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0152

C

Seeded From UniProt

complete

part_of

GO:0030496

midbody

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0469

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 He, S et al. (2013) PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat. Cell Biol. 15 1206-19 PubMed GONUTS page
  2. ↑ 2.0 2.1 Cheng, X et al. (2017) Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17. Mol. Cell 65 1029-1043.e5 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Thoresen, SB et al. (2010) A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp. Cell Res. 316 3368-78 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Zhao, Z et al. (2012) A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Dev. Cell 22 1001-16 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Matsunaga, K et al. (2009) Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 11 385-96 PubMed GONUTS page
  6. ↑ 6.0 6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Metcalf, D & Isaacs, AM (2010) The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes. Biochem. Soc. Trans. 38 1469-73 PubMed GONUTS page
  8. ↑ 8.0 8.1 Perelman, B et al. (1997) Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. Genomics 41 397-405 PubMed GONUTS page
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