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HUMAN:RFIP3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RAB11FIP3 (synonyms: ARFO1, KIAA0665)
Protein Name(s) Rab11 family-interacting protein 3

FIP3-Rab11 Rab11-FIP3 Arfophilin-1 EF hands-containing Rab-interacting protein Eferin MU-MB-17.148

External Links
UniProt O75154
EMBL AF395731
AB014565
AK293644
AK303061
AE006463
AL023881
AL049542
Z98882
AL049542
AL023881
Z98882
AL023881
AL049542
Z98882
AL049542
AL023881
Z98882
Z98882
AL023881
AL049542
Z98882
AL023881
AL049542
BC051360
AY130007
CCDS CCDS32351.1
CCDS45364.1
PIR T00367
RefSeq NP_001135744.1
NP_055515.1
XP_005255770.1
XP_005255772.1
XP_006725305.1
XP_006725309.1
UniGene Hs.531642
PDB 2D7C
2HV8
4D0M
PDBsum 2D7C
2HV8
4D0M
ProteinModelPortal O75154
SMR O75154
BioGrid 115076
IntAct O75154
MINT MINT-6799564
STRING 9606.ENSP00000262305
PhosphoSite O75154
MaxQB O75154
PaxDb O75154
PRIDE O75154
Ensembl ENST00000262305
ENST00000450428
ENST00000610934
ENST00000611004
GeneID 9727
KEGG hsa:9727
UCSC uc002chf.3
uc010uuf.2
uc010uug.2
CTD 9727
GeneCards GC16P000475
HGNC HGNC:17224
HPA HPA028088
HPA028631
HPA030086
MIM 608738
neXtProt NX_O75154
PharmGKB PA134950896
eggNOG NOG259959
GeneTree ENSGT00440000033742
HOVERGEN HBG054059
InParanoid O75154
KO K12485
OMA DFGESNT
OrthoDB EOG793B75
PhylomeDB O75154
TreeFam TF327221
ChiTaRS RAB11FIP3
EvolutionaryTrace O75154
GeneWiki RAB11FIP3
GenomeRNAi 9727
NextBio 36593
PRO PR:O75154
Proteomes UP000005640
UP000005640
Bgee O75154
CleanEx HS_RAB11FIP3
ExpressionAtlas O75154
Genevestigator O75154
GO GO:0005813
GO:0032154
GO:0005768
GO:0045171
GO:0043231
GO:0005815
GO:0030496
GO:0005634
GO:0055037
GO:0055038
GO:0030306
GO:0005509
GO:0042803
GO:0017137
GO:0000910
GO:0032456
GO:0016192
Gene3D 1.10.238.10
InterPro IPR011992
IPR002048
IPR019018
Pfam PF13499
PF09457
SMART SM00054
PROSITE PS50222
PS51511

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0070164

negative regulation of adiponectin secretion

PMID:24040321[1]

ECO:0000314

P

Figure 1A

complete
CACAO 8901

Colocalizes with

GO:0036449

microtubule minus-end

PMID:15601896[2]

ECO:0000314

C

Homo Sapiens, Rab11 family-interacting protein 3 (FIP3)

In figure 3E, fixed HeLa cells show that FIP3 starts accumulating at the minus end of microtubules during telophase.

complete
CACAO 12985

Colocalizes with

GO:0051233

spindle midzone

PMID:15601896[2]

ECO:0000314

C

Homo Sapiens, Rab11 family-interacting protein 3 (FIP3)

In Figure 3D, it is shown that FIP3 is associated with the spindle midzone during anaphase.

complete
CACAO 13003

involved_in

GO:0070164

negative regulation of adiponectin secretion

PMID:24040321[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0055037

recycling endosome

PMID:17394487[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:17030804[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:17394487[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032456

endocytic recycling

PMID:17394487[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032154

cleavage furrow

PMID:18511905[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032154

cleavage furrow

PMID:16148947[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032154

cleavage furrow

PMID:15601896[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030496

midbody

PMID:18511905[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030496

midbody

PMID:16148947[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030496

midbody

PMID:15601896[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030306

ADP-ribosylation factor binding

PMID:18511905[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P62330

F

Seeded From UniProt

complete

enables

GO:0030306

ADP-ribosylation factor binding

PMID:17030804[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P62330

F

Seeded From UniProt

complete

enables

GO:0030306

ADP-ribosylation factor binding

PMID:16148947[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P62330

F

Seeded From UniProt

complete

enables

GO:0030306

ADP-ribosylation factor binding

PMID:17030804[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P84085

F

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

PMID:18511905[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P62491

F

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

PMID:16148947[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P62491

F

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

PMID:15601896[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P62491

F

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

PMID:17030804[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P62491

F

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

PMID:11481332[7]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:15601896[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:16148947[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:15601896[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032465

regulation of cytokinesis

PMID:16148947[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032465

regulation of cytokinesis

PMID:15601896[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0055038

recycling endosome membrane

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002311891
UniProtKB:Q86YS3

C

Seeded From UniProt

complete

involved_in

GO:0032465

regulation of cytokinesis

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002311891
UniProtKB:O75154
UniProtKB:Q86YS3

P

Seeded From UniProt

complete

involved_in

GO:0032456

endocytic recycling

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002311891
UniProtKB:O75154

P

Seeded From UniProt

complete

part_of

GO:0032154

cleavage furrow

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002311891
UniProtKB:O75154
UniProtKB:Q86YS3

C

Seeded From UniProt

complete

part_of

GO:0030496

midbody

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002311891
UniProtKB:O75154
UniProtKB:Q86YS3

C

Seeded From UniProt

complete

enables

GO:0030306

ADP-ribosylation factor binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002311891
UniProtKB:O75154
UniProtKB:Q86YS3

F

Seeded From UniProt

complete

part_of

GO:0030139

endocytic vesicle

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002311891
UniProtKB:Q86YS3

C

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002311891
UniProtKB:O75154
UniProtKB:Q86YS3

F

Seeded From UniProt

complete

colocalizes_with

GO:0005813

centrosome

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0013718
PANTHER:PTN002311891
UniProtKB:O75154

C

Seeded From UniProt

complete

part_of

GO:0045171

intercellular bridge

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0051959

dynein light intermediate chain binding

PMID:25272277[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9Y6G9

F

Seeded From UniProt

complete

involved_in

GO:0061512

protein localization to cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CHD8
ensembl:ENSMUSP00000113521

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CHD8
ensembl:ENSMUSP00000113521

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002048

F

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032920

P

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032920

F

Seeded From UniProt

complete

enables

GO:0030306

ADP-ribosylation factor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032920

F

Seeded From UniProt

complete

involved_in

GO:0032456

endocytic recycling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032920

P

Seeded From UniProt

complete

involved_in

GO:0032465

regulation of cytokinesis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032920

P

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

PMID:16148947[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5623527
Reactome:R-HSA-5623525
Reactome:R-HSA-5623524
Reactome:R-HSA-5623521
Reactome:R-HSA-5623519
Reactome:R-HSA-5623513
Reactome:R-HSA-5620921

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

part_of

GO:0055038

recycling endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0231

C

Seeded From UniProt

complete

part_of

GO:0030496

midbody

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0469

C

Seeded From UniProt

complete

part_of

GO:0032154

cleavage furrow

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0467

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Carson, BP et al. (2013) The rab11 effector protein FIP1 regulates adiponectin trafficking and secretion. PLoS ONE 8 e74687 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Wilson, GM et al. (2005) The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Mol. Biol. Cell 16 849-60 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Horgan, CP et al. (2007) Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment. Traffic 8 414-30 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Shiba, T et al. (2006) Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. Proc. Natl. Acad. Sci. U.S.A. 103 15416-21 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Simon, GC et al. (2008) Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. EMBO J. 27 1791-803 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Fielding, AB et al. (2005) Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. EMBO J. 24 3389-99 PubMed GONUTS page
  7. ↑ Prekeris, R et al. (2001) Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. J. Biol. Chem. 276 38966-70 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  9. ↑ Schroeder, CM et al. (2014) A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region. Elife 3 e03351 PubMed GONUTS page
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