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HUMAN:PCH2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TRIP13 (synonyms: PCH2)
Protein Name(s) Pachytene checkpoint protein 2 homolog

Human papillomavirus type 16 E1 protein-binding protein 16E1-BP HPV16 E1 protein-binding protein Thyroid hormone receptor interactor 13 Thyroid receptor-interacting protein 13 TR-interacting protein 13 TRIP-13

External Links
UniProt Q15645
EMBL U96131
CR456744
AC122719
CH471102
CH471102
BC000404
BC019294
L40384
CCDS CCDS3858.1
RefSeq NP_004228.1
UniGene Hs.436187
ProteinModelPortal Q15645
SMR Q15645
BioGrid 114730
DIP DIP-34493N
IntAct Q15645
MINT MINT-1146352
STRING 9606.ENSP00000166345
PhosphoSite Q15645
DMDM 85541056
MaxQB Q15645
PaxDb Q15645
PeptideAtlas Q15645
PRIDE Q15645
DNASU 9319
Ensembl ENST00000166345
GeneID 9319
KEGG hsa:9319
UCSC uc003jbr.3
CTD 9319
GeneCards GC05P000892
HGNC HGNC:12307
HPA HPA005727
HPA053093
MIM 604507
neXtProt NX_Q15645
PharmGKB PA36986
eggNOG COG0464
GeneTree ENSGT00390000017432
HOGENOM HOG000234557
HOVERGEN HBG052830
InParanoid Q15645
OMA VQIHVEV
OrthoDB EOG71VST9
PhylomeDB Q15645
TreeFam TF313507
GeneWiki TRIP13
GenomeRNAi 9319
NextBio 34909
PRO PR:Q15645
Proteomes UP000005640
Bgee Q15645
CleanEx HS_TRIP13
Genevestigator Q15645
GO GO:0001673
GO:0005634
GO:0005524
GO:0003712
GO:0006302
GO:0007144
GO:0007141
GO:0001556
GO:0048477
GO:0007131
GO:1903506
GO:0007286
GO:0007283
GO:0007130
GO:0006366
Gene3D 3.40.50.300
InterPro IPR003593
IPR003959
IPR003960
IPR001270
IPR027417
Pfam PF00004
PRINTS PR00300
SMART SM00382
SUPFAM SSF52540
PROSITE PS00674

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0007094

mitotic spindle assembly checkpoint

PMID:28553959[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048477

oogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UA06

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UA06

P

Seeded From UniProt

complete

involved_in

GO:0007131

reciprocal meiotic recombination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UA06

P

Seeded From UniProt

complete

involved_in

GO:0007130

synaptonemal complex assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UA06

P

Seeded From UniProt

complete

involved_in

GO:0006302

double-strand break repair

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UA06

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:9223484[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051598

meiotic recombination checkpoint

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0051453
PANTHER:PTN000554401
SGD:S000000390

P

Seeded From UniProt

complete

involved_in

GO:0007131

reciprocal meiotic recombination

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1916966
PANTHER:PTN000554401
SGD:S000000390
UniProtKB:Q7XK25

P

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000554401
UniProtKB:Q7XK25
UniProtKB:Q8H1F9

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000554401
UniProtKB:Q7XK25

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15645

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16189514[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15645

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16169070[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15645

F

Seeded From UniProt

complete

involved_in

GO:1903506

regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003712

P

Seeded From UniProt

complete

involved_in

GO:0048477

oogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UA06
ensembl:ENSMUSP00000022053

P

Seeded From UniProt

complete

involved_in

GO:0007286

spermatid development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UA06
ensembl:ENSMUSP00000022053

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UA06
ensembl:ENSMUSP00000022053

P

Seeded From UniProt

complete

involved_in

GO:0007144

female meiosis I

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UA06
ensembl:ENSMUSP00000022053

P

Seeded From UniProt

complete

involved_in

GO:0007141

male meiosis I

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UA06
ensembl:ENSMUSP00000022053

P

Seeded From UniProt

complete

involved_in

GO:0007131

reciprocal meiotic recombination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UA06
ensembl:ENSMUSP00000022053

P

Seeded From UniProt

complete

involved_in

GO:0007130

synaptonemal complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UA06
ensembl:ENSMUSP00000022053

P

Seeded From UniProt

complete

involved_in

GO:0006302

double-strand break repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UA06
ensembl:ENSMUSP00000022053

P

Seeded From UniProt

complete

part_of

GO:0001673

male germ cell nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UA06
ensembl:ENSMUSP00000022053

C

Seeded From UniProt

complete

involved_in

GO:0001556

oocyte maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UA06
ensembl:ENSMUSP00000022053

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001270
InterPro:IPR003959
InterPro:IPR003960

F

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

PMID:7776974[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:7776974[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003712

transcription coregulator activity

PMID:7776974[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0469

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0744

P

Seeded From UniProt

complete

involved_in

GO:0048477

oogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0896

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Yost, S et al. (2017) Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation. Nat. Genet. 49 1148-1151 PubMed GONUTS page
  2. ↑ Yasugi, T et al. (1997) Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins. J. Virol. 71 5942-51 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
  5. ↑ Rual, JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 1173-8 PubMed GONUTS page
  6. ↑ Stelzl, U et al. (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell 122 957-68 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Lee, JW et al. (1995) Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Mol. Endocrinol. 9 243-54 PubMed GONUTS page
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