HUMAN:KPYM

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PKM (synonyms: OIP3, PK2, PK3, PKM2)
Protein Name(s)	Pyruvate kinase PKM Cytosolic thyroid hormone-binding protein CTHBP Opa-interacting protein 3 OIP-3 Pyruvate kinase 2/3 Pyruvate kinase muscle isozyme Thyroid hormone-binding protein 1 THBP1 Tumor M2-PK p58
External Links
UniProt	P14618
EMBL	M23725 M26252 X56494 AK092369 AK222927 AK294315 AK300800 AK312253 AY352517 AC020779 CH471082 CH471082 BC000481 BC007640 BC007952 BC012811 BC035198 AF025439
CCDS	CCDS32284.1 CCDS32285.1 CCDS55972.1
PIR	S30038 S64635
RefSeq	NP_001193725.1 NP_001193726.1 NP_001193727.1 NP_001193728.1 NP_002645.3 NP_872270.1 NP_872271.1 XP_005254502.1
UniGene	Hs.534770
PDB	1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG
PDBsum	1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG
ProteinModelPortal	P14618
SMR	P14618
BioGrid	111332
DIP	DIP-31273N
IntAct	P14618
MINT	MINT-4998892
BindingDB	P14618
ChEMBL	CHEMBL1075189
DrugBank	DB00119
PhosphoSite	P14618
DMDM	20178296
DOSAC-COBS-2DPAGE	P14618
OGP	P14618
REPRODUCTION-2DPAGE	IPI00220644 IPI00479186
UCD-2DPAGE	P14618
MaxQB	P14618
PaxDb	P14618
PRIDE	P14618
DNASU	5315
Ensembl	ENST00000319622 ENST00000335181 ENST00000449901 ENST00000565154 ENST00000565184 ENST00000568459
GeneID	5315
KEGG	hsa:5315
UCSC	uc002atv.2 uc002aty.2 uc010ukj.2
CTD	5315
GeneCards	GC15M072492
HGNC	HGNC:9021
HPA	CAB019421 HPA029501
MIM	179050
neXtProt	NX_P14618
PharmGKB	PA33353
eggNOG	COG0469
GeneTree	ENSGT00390000008859
HOGENOM	HOG000021559
HOVERGEN	HBG000941
InParanoid	P14618
KO	K00873
OMA	DVPYFEK
OrthoDB	EOG78M01Q
PhylomeDB	P14618
TreeFam	TF300390
BioCyc	MetaCyc:HS00906-MONOMER
Reactome	REACT_1383
SABIO-RK	P14618
UniPathway	UPA00109
EvolutionaryTrace	P14618
GeneWiki	PKM2
GenomeRNAi	5315
NextBio	20554
PRO	PR:P14618
Proteomes	UP000005640
Bgee	P14618
CleanEx	HS_PKM2
ExpressionAtlas	P14618
Genevestigator	P14618
GO	GO:0005929 GO:0005737 GO:0005829 GO:0031012 GO:0070062 GO:0005739 GO:0005634 GO:0005886 GO:0031982 GO:0005524 GO:0000287 GO:0023026 GO:0044822 GO:0030955 GO:0004743 GO:0005975 GO:0006006 GO:0006096 GO:0012501 GO:0044281
Gene3D	2.40.33.10 3.20.20.60 3.40.1380.20
InterPro	IPR001697 IPR015813 IPR011037 IPR015794 IPR018209 IPR015793 IPR015795 IPR015806
PANTHER	PTHR11817
Pfam	PF00224 PF02887
PRINTS	PR01050
SUPFAM	SSF50800 SSF51621 SSF52935
TIGRFAMs	TIGR01064
PROSITE	PS00110

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004743	pyruvate kinase activity	PMID:20005212^[1]	ECO:0000314			F		Figure 2 kinetic characterization of enzyme activity	complete CACAO 6188
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	PMID:27199445^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	PMID:20005212^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:23658023^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:19190083^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002202)	Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	PMID:24769233^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001359)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
enables	GO:0023026	MHC class II protein complex binding	PMID:20458337^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:20833797^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001134)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:11487543^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002563)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:12519789^[14]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0000236)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:21362503^[15]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002367)	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[16]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0012501	programmed cell death	PMID:17308100^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:2813362^[18]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18298799^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17308100^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18191611^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000212861 RGD:3336	P		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10803 EcoGene:EG10804 MGI:MGI:97591 PANTHER:PTN000212670 RGD:3336 RGD:3337 SGD:S000000036 UniProtKB:Q2RAK2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000212670 SGD:S000000036 UniProtKB:P14618	C		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10803 EcoGene:EG10804 MGI:MGI:97591 MGI:MGI:97604 PANTHER:PTN000212670 PomBase:SPAC4H3.10c RGD:3336 RGD:3337 SGD:S000000036 SGD:S000005874 TAIR:locus:2033760 TAIR:locus:2084583 TAIR:locus:2176912 UniProtKB:C6KTA4 UniProtKB:P14618 UniProtKB:P30613 UniProtKB:Q2RAK2	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1902912	pyruvate kinase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	C		Seeded From UniProt	complete
enables	GO:0070324	thyroid hormone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	F		Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
enables	GO:0043531	ADP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	F		Seeded From UniProt	complete
involved_in	GO:0043403	skeletal muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
involved_in	GO:0042866	pyruvate biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	F		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
involved_in	GO:0014870	response to muscle inactivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
involved_in	GO:0009629	response to gravity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
involved_in	GO:0006754	ATP biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	F		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11980 ensembl:ENSRNOP00000015331	P		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52480 ensembl:ENSMUSP00000034834	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52480 ensembl:ENSMUSP00000034834	C		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52480 ensembl:ENSMUSP00000034834	F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001697 InterPro:IPR015793	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015813	F		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001697 InterPro:IPR015793 InterPro:IPR015806 InterPro:IPR018209	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001697 InterPro:IPR015793 InterPro:IPR015806 InterPro:IPR018209	P		Seeded From UniProt	complete
enables	GO:0030955	potassium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001697 InterPro:IPR015793	F		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.40	F		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	PMID:2854097^[22] PMID:2813362^[18] PMID:2040271^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1904813	ficolin-1-rich granule lumen	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061621	canonical glycolysis	Reactome:R-HSA-70171	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-71670	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6800434 Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324 UniPathway:UPA00109	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vander Heiden, MG et al. (2010) Identification of small molecule inhibitors of pyruvate kinase M2. Biochem. Pharmacol. 79 1118-24 PubMed GONUTS page
↑ Boeckel, JN et al. (2016) JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells. Arterioscler. Thromb. Vasc. Biol. 36 1425-33 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Kesimer, M et al. (2009) Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 23 1858-68 PubMed GONUTS page
↑ Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ Zhao, X et al. (2011) Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Mol. Cell Proteomics 10 M110.000299 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ van Niel, G et al. (2001) Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology 121 337-49 PubMed GONUTS page
↑ Wubbolts, R et al. (2003) Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J. Biol. Chem. 278 10963-72 PubMed GONUTS page
↑ Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^17.0 ^17.1 Steták, A et al. (2007) Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death. Cancer Res. 67 1602-8 PubMed GONUTS page
↑ ^18.0 ^18.1 Kato, H et al. (1989) Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase. Proc. Natl. Acad. Sci. U.S.A. 86 7861-5 PubMed GONUTS page
↑ Shimada, N et al. (2008) Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein. Genes Cells 13 245-54 PubMed GONUTS page
↑ Lee, J et al. (2008) Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int. J. Biochem. Cell Biol. 40 1043-54 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Tani, K et al. (1988) Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma. Gene 73 509-16 PubMed GONUTS page
↑ Takenaka, M et al. (1991) Isolation and characterization of the human pyruvate kinase M gene. Eur. J. Biochem. 198 101-6 PubMed GONUTS page

[PMID:20005212-1] 1.0 ^1.1 Vander Heiden, MG et al. (2010) Identification of small molecule inhibitors of pyruvate kinase M2. Biochem. Pharmacol. 79 1118-24 PubMed GONUTS page

[PMID:27199445-2] Boeckel, JN et al. (2016) JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells. Arterioscler. Thromb. Vasc. Biol. 36 1425-33 PubMed GONUTS page

[PMID:25468996-3] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:23658023-4] Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page

[PMID:23533145-5] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19190083-6] Kesimer, M et al. (2009) Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 23 1858-68 PubMed GONUTS page

[PMID:24769233-7] Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page

[PMID:19199708-8] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-9] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-10] 10.0 ^10.1 ^10.2 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:20833797-11] Zhao, X et al. (2011) Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Mol. Cell Proteomics 10 M110.000299 PubMed GONUTS page

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HUMAN:KPYM

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