HUMAN:HUWE1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HUWE1 (synonyms: KIAA0312, KIAA1578, UREB1)
Protein Name(s)	E3 ubiquitin-protein ligase HUWE1 ARF-binding protein 1 ARF-BP1 HECT, UBA and WWE domain-containing protein 1 HECT-type E3 ubiquitin transferase HUWE1 Homologous to E6AP carboxyl terminus homologous protein 9 HectH9 Large structure of UREB1 LASU1 Mcl-1 ubiquitin ligase E3 Mule Upstream regulatory element-binding protein 1 URE-B1 URE-binding protein 1
External Links
UniProt	Q7Z6Z7
EMBL	AY772009 DQ097177 AY929612 AL592046 Z94044 Z97054 Z94044 AL592046 Z97054 Z97054 AL592046 Z94044 AB071605 AB002310 AB046798 AF161390 BC002602 BC063505 AF057569 CR456813 AL162050
CCDS	CCDS35301.1
PIR	T47165
RefSeq	NP_113584.3 XP_005262022.1
UniGene	Hs.136905
PDB	2EKK 2MUL 3G1N 3H1D 5C6H 5LP8
PDBsum	2EKK 2MUL 3G1N 3H1D 5C6H 5LP8
ProteinModelPortal	Q7Z6Z7
SMR	Q7Z6Z7
BioGrid	115385
CORUM	Q7Z6Z7
DIP	DIP-34362N
ELM	Q7Z6Z7
IntAct	Q7Z6Z7
MINT	Q7Z6Z7
STRING	9606.ENSP00000262854
CarbonylDB	Q7Z6Z7
iPTMnet	Q7Z6Z7
PhosphoSitePlus	Q7Z6Z7
BioMuta	HUWE1
DMDM	73915353
EPD	Q7Z6Z7
MaxQB	Q7Z6Z7
PaxDb	Q7Z6Z7
PeptideAtlas	Q7Z6Z7
PRIDE	Q7Z6Z7
ProteomicsDB	69472 69473 69474
Ensembl	ENST00000262854 ENST00000342160 ENST00000612484
GeneID	10075
KEGG	hsa:10075
UCSC	uc033eew.2
CTD	10075
DisGeNET	10075
EuPathDB	HostDB:ENSG00000086758.15
GeneCards	HUWE1
HGNC	HGNC:30892
HPA	CAB022718 HPA002548
MalaCards	HUWE1
MIM	300697 300705 300706
neXtProt	NX_Q7Z6Z7
OpenTargets	ENSG00000086758
Orphanet	85328
PharmGKB	PA128394567
eggNOG	KOG0939 COG5021
GeneTree	ENSGT00850000132302
HOVERGEN	HBG080254
InParanoid	Q7Z6Z7
KO	K10592
OMA	GDLYHWI
OrthoDB	EOG091G01V1
PhylomeDB	Q7Z6Z7
TreeFam	TF323417
BRENDA	6.3.2.19
Reactome	R-HSA-6798695 R-HSA-983168
UniPathway	UPA00143
ChiTaRS	HUWE1
EvolutionaryTrace	Q7Z6Z7
GeneWiki	HUWE1
GenomeRNAi	10075
PRO	PR:Q7Z6Z7
Proteomes	UP000005640
Bgee	ENSG00000086758
ExpressionAtlas	Q7Z6Z7
Genevisible	Q7Z6Z7
GO	GO:0005737 GO:0005829 GO:0070062 GO:0005576 GO:1904813 GO:0016020 GO:0005654 GO:0005634 GO:0034774 GO:0003677 GO:0003723 GO:0061630 GO:0004842 GO:0006284 GO:0030154 GO:0016574 GO:0043312 GO:1903955 GO:0006513 GO:0000209
CDD	cd00078
Gene3D	3.30.720.50
InterPro	IPR016024 IPR025527 IPR010309 IPR010314 IPR000569 IPR035983 IPR015940 IPR009060 IPR004170 IPR037197
Pfam	PF14377 PF06012 PF06025 PF00632 PF00627 PF02825
SMART	SM00119 SM00165
SUPFAM	SSF117839 SSF46934 SSF48371 SSF56204
PROSITE	PS50237 PS50030 PS50918

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0032922	circadian regulation of gene expression	PMID:20534529^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:20534529^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903955	positive regulation of protein targeting to mitochondrion	PMID:24270810^[2]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016574	histone ubiquitination	PMID:15767685^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006513	protein monoubiquitination	PMID:19713937^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	PMID:19713937^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19713937^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51593	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:19713937^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:15989957^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51593	F		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:15989957^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1933754 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q9HCE7	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1923038 MGI:MGI:97297 PANTHER:PTN000134256 SGD:S000000927 SGD:S000002865 TAIR:locus:2135630 UniProtKB:O00308 UniProtKB:P46934 UniProtKB:Q5BDP1 UniProtKB:Q8IYU2 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HCE7 WB:WBGene00007009	P		Seeded From UniProt	complete
	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	PMID:30217973^[10]	ECO:0000314			P		Figure 1 and Supplementary Fig. 1- It is positive regulation of mitophagy because HUWE1 depletion impairs AMBRA1-mediated mitophagy. The O/A treatments are indicative of mitochondrial depolarization. Supplementary Table 1- The Bethyl catalogue number for the HUWE1 antibody tells us that the protein is a human protein. Organism- Human	complete CACAO 13323
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135257 SGD:S000002865 UniProtKB:Q8IYU2	P		Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000134864 UniProtKB:Q7Z6Z7	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003557 FB:FBgn0259174 MGI:MGI:1202301 MGI:MGI:1914144 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c SGD:S000000927 TAIR:locus:2135630 UniProtKB:P46934 UniProtKB:Q7Z6Z7 UniProtKB:Q9HCE7 WB:WBGene00007009	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000745052 RGD:1561763	C		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002258114 UniProtKB:Q7Z6Z7	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000569 InterPro:IPR035983	F		Seeded From UniProt	complete
part_of	GO:1904813	ficolin-1-rich granule lumen	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-983157 Reactome:R-HSA-983156 Reactome:R-HSA-983147 Reactome:R-HSA-983140	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6800434 Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	Reactome:R-HSA-983168	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yin, L et al. (2010) E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha. Proc. Natl. Acad. Sci. U.S.A. 107 11614-9 PubMed GONUTS page
↑ Hasson, SA et al. (2013) High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature 504 291-5 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ Liu, Z et al. (2005) Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones. Mol. Cell. Biol. 25 2819-31 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Parsons, JL et al. (2009) Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. EMBO J. 28 3207-15 PubMed GONUTS page
↑ ^8.0 ^8.1 Zhong, Q et al. (2005) Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 121 1085-95 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Di Rita, A et al. (2018) HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα. Nat Commun 9 3755 PubMed GONUTS page

[PMID:20534529-1] 1.0 ^1.1 Yin, L et al. (2010) E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha. Proc. Natl. Acad. Sci. U.S.A. 107 11614-9 PubMed GONUTS page

[PMID:24270810-2] Hasson, SA et al. (2013) High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature 504 291-5 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19056867-4] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:22658674-5] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:15767685-6] Liu, Z et al. (2005) Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones. Mol. Cell. Biol. 25 2819-31 PubMed GONUTS page

[PMID:19713937-7] 7.0 ^7.1 ^7.2 ^7.3 Parsons, JL et al. (2009) Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. EMBO J. 28 3207-15 PubMed GONUTS page

[PMID:15989957-8] 8.0 ^8.1 Zhong, Q et al. (2005) Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 121 1085-95 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:30217973-10] Di Rita, A et al. (2018) HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα. Nat Commun 9 3755 PubMed GONUTS page

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HUMAN:HUWE1

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