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HUMAN:GEMI

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) GMNN
Protein Name(s) Geminin
External Links
UniProt O75496
EMBL AF067855
AK021685
AL133264
BC005185
BC005389
CCDS CCDS4560.1
RefSeq NP_001238918.1
NP_001238919.1
NP_001238920.1
NP_056979.1
XP_005249216.1
UniGene Hs.234896
PDB 1T6F
1UII
2LP0
2WVR
4BRY
PDBsum 1T6F
1UII
2LP0
2WVR
4BRY
ProteinModelPortal O75496
SMR O75496
BioGrid 119246
DIP DIP-31088N
IntAct O75496
MINT MINT-1201770
STRING 9606.ENSP00000230056
ChEMBL CHEMBL1293278
PhosphoSite O75496
MaxQB O75496
PaxDb O75496
PRIDE O75496
DNASU 51053
Ensembl ENST00000230056
ENST00000356509
ENST00000620958
GeneID 51053
KEGG hsa:51053
UCSC uc003nem.3
CTD 51053
GeneCards GC06P024779
HGNC HGNC:17493
HPA CAB011458
CAB047327
CAB047328
HPA049977
HPA054597
MIM 602842
neXtProt NX_O75496
PharmGKB PA38455
eggNOG NOG39688
GeneTree ENSGT00390000016394
HOGENOM HOG000112711
HOVERGEN HBG002965
InParanoid O75496
KO K10749
OMA VPEHSEN
OrthoDB EOG7RFTJX
PhylomeDB O75496
TreeFam TF101171
Reactome REACT_1181
REACT_1949
REACT_207
ChiTaRS GMNN
EvolutionaryTrace O75496
GeneWiki Geminin
GenomeRNAi 51053
NextBio 53616
PMAP-CutDB O75496
PRO PR:O75496
Proteomes UP000005640
Bgee O75496
CleanEx HS_GMNN
ExpressionAtlas O75496
Genevestigator O75496
GO GO:0005737
GO:0005829
GO:0005654
GO:0005634
GO:0042826
GO:0003714
GO:0000278
GO:0045786
GO:0008156
GO:0045892
GO:0009887
GO:0006461
InterPro IPR029697
IPR022786
PANTHER PTHR13372:SF4
Pfam PF07412

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008156

negative regulation of DNA replication

PMID:11125146[1]

ECO:0000314

P

Fig.3

complete

involved_in

GO:0006275

regulation of DNA replication

PMID:17234884[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035563

positive regulation of chromatin binding

PMID:11125146[1]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q91628)

Seeded From UniProt

complete

involved_in

GO:0071163

DNA replication preinitiation complex assembly

PMID:11125146[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000104

negative regulation of DNA-dependent DNA replication

PMID:11125146[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:11125146[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:16924111[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045786

negative regulation of cell cycle

PMID:9635433[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

PMID:16924111[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O15379

F

Seeded From UniProt

complete

involved_in

GO:0008156

negative regulation of DNA replication

PMID:9635433[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21543332[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21543332[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24217620[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0070491

repressing transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88513
ensembl:ENSMUSP00000006898

F

Seeded From UniProt

complete

involved_in

GO:0065003

protein-containing complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88513
ensembl:ENSMUSP00000006898

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88513
ensembl:ENSMUSP00000006898

P

Seeded From UniProt

complete

involved_in

GO:0045786

negative regulation of cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88513
ensembl:ENSMUSP00000006898

P

Seeded From UniProt

complete

involved_in

GO:0009887

animal organ morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88513
ensembl:ENSMUSP00000006898

P

Seeded From UniProt

complete

involved_in

GO:0008156

negative regulation of DNA replication

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88513
ensembl:ENSMUSP00000006898

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88513
ensembl:ENSMUSP00000006898

C

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88513
ensembl:ENSMUSP00000006898

F

Seeded From UniProt

complete

involved_in

GO:0006275

regulation of DNA replication

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR022786

P

Seeded From UniProt

complete

involved_in

GO:0008156

negative regulation of DNA replication

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029697

P

Seeded From UniProt

complete

involved_in

GO:0045786

negative regulation of cell cycle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029697

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-68825
Reactome:R-HSA-68712

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-69299

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

Reactome:R-HSA-69206

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008156

negative regulation of DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0236

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Wohlschlegel, JA et al. (2000) Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 290 2309-12 PubMed GONUTS page
  2. ↑ Machida, YJ & Dutta, A (2007) The APC/C inhibitor, Emi1, is essential for prevention of rereplication. Genes Dev. 21 184-94 PubMed GONUTS page
  3. ↑ 3.0 3.1 Kim, MY et al. (2006) A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Proc. Natl. Acad. Sci. U.S.A. 103 13074-9 PubMed GONUTS page
  4. ↑ 4.0 4.1 McGarry, TJ & Kirschner, MW (1998) Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93 1043-53 PubMed GONUTS page
  5. ↑ 5.0 5.1 Pefani, DE et al. (2011) Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression. J. Biol. Chem. 286 23234-46 PubMed GONUTS page
  6. ↑ Mosammaparast, N et al. (2013) The histone demethylase LSD1/KDM1A promotes the DNA damage response. J. Cell Biol. 203 457-70 PubMed GONUTS page
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