HUMAN:BLM

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	BLM ( synonyms: RECQ2, RECQL3 )
Protein Name(s)	Bloom syndrome protein DNA helicase, RecQ-like type 2 RecQ2 RecQ protein-like 3
External Links
UniProt Identifier	BLM_HUMAN
UniProt Accessions	P54132, Q52M96,
EMBL	U39817, AY886902, BC093622, BC101567, BC115030, BC115032,
PIR	A57570,
RefSeq	NP_000048.1,
PDB	2KV2, 2RRD,
IntAct	P54132,
Ensembl	ENST00000355112,
Pfam	PF08072, PF00270, PF00271, PF00570, PF09382,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005737	cytoplasm		IDA: Inferred from Direct Assay		C	Source: HPA
	GO:0000800	lateral element		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0016363	nuclear matrix		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005730	nucleolus		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0016605	PML body		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005524	ATP binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0000405	bubble DNA binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0000739	DNA strand annealing activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0009378	four-way junction helicase activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0051880	G-quadruplex DNA binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0002039	p53 binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0000724	double-strand break repair via homologous r...		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0000085	G2 phase of mitotic cell cycle		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0031572	G2/M transition DNA damage checkpoint		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0051782	negative regulation of cell division		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0045941	positive regulation of transcription		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0051259	protein oligomerization		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0000079	regulation of cyclin-dependent protein kina...		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0031297	replication fork processing		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0048478	replication fork protection		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0010165	response to X-ray		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0000079	regulation of cyclin-dependent protein kinase activity	PMID:15604258^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0000085	G2 phase of mitotic cell cycle	PMID:11309417^[2]	NAS: Non-traceable Author Statement		P
	GO:0000166	nucleotide binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010997	F
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0000405	bubble DNA binding	PMID:11433031^[3]	IDA: Inferred from Direct Assay		F
	GO:0000724	double-strand break repair via homologous recombination	PMID:11309417^[2]	NAS: Non-traceable Author Statement		P
	GO:0000733	DNA strand renaturation	PMID:17878217^[4]	IDA: Inferred from Direct Assay		P
	GO:0000739	DNA strand annealing activity	PMID:17878217^[4]	IDA: Inferred from Direct Assay		F
	GO:0000800	lateral element	PMID:10728666^[5]	IDA: Inferred from Direct Assay		C
	GO:0001673	male germ cell nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000127995	C
	GO:0002039	p53 binding	PMID:11781842^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P04637	F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002121	F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002464	F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011545	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012532	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003697	single-stranded DNA binding	PMID:12818200^[7]	IDA: Inferred from Direct Assay		F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010997	F
	GO:0004003	ATP-dependent DNA helicase activity	PMID:9388193^[8]	IDA: Inferred from Direct Assay		F
	GO:0004386	helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0004386	helicase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0347	F
	GO:0004386	helicase activity	PMID:10871376^[9]	IDA: Inferred from Direct Assay		F
	GO:0004386	helicase activity	PMID:12181313^[10]	IDA: Inferred from Direct Assay		F
	GO:0004386	helicase activity	PMID:17878217^[4]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:10728666^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q13472	F
	GO:0005515	protein binding	PMID:10825162^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P27694	F
	GO:0005515	protein binding	PMID:11309417^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q06609	F
	GO:0005515	protein binding	PMID:11919194^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q14191	F
	GO:0005515	protein binding	PMID:12181313^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q15554	F
	GO:0005515	protein binding	PMID:14688284^[13]	IPI: Inferred from Physical Interaction	UniProtKB:P39748	F
	GO:0005515	protein binding	PMID:15229185^[14]	IPI: Inferred from Physical Interaction	UniProtKB:P54274	F
	GO:0005515	protein binding	PMID:15229185^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q15554	F
	GO:0005515	protein binding	PMID:15965237^[15]	IPI: Inferred from Physical Interaction	UniProtKB:P27694	F
	GO:0005515	protein binding	PMID:16030011^[16]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NUX5	F
	GO:0005515	protein binding	PMID:17961633^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IYB8	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002464	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011545	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012532	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005524	ATP binding	PMID:17878217^[4]	IDA: Inferred from Direct Assay		F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002121	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012532	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:11500040^[18]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18029348^[19]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:9388480^[20]	IDA: Inferred from Direct Assay		C
	GO:0005657	replication fork	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000127995	C
	GO:0005730	nucleolus	PMID:10779560^[21]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000127995	C
	GO:0005737	cytoplasm	PMID:18029348^[19]	IDA: Inferred from Direct Assay		C
	GO:0006200	ATP catabolic process	PMID:17878217^[4]	IDA: Inferred from Direct Assay		P
	GO:0006260	DNA replication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012532	P
	GO:0006260	DNA replication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018982	P
	GO:0006260	DNA replication	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0235	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018982	P
	GO:0006281	DNA repair	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000127995	P
	GO:0006281	DNA repair	PMID:7585968^[22]	NAS: Non-traceable Author Statement		P
	GO:0006310	DNA recombination	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004589	P
	GO:0006310	DNA recombination	PMID:10728666^[5]	NAS: Non-traceable Author Statement		P
	GO:0006310	DNA recombination	PMID:7585968^[22]	NAS: Non-traceable Author Statement		P
	GO:0006974	response to DNA damage stimulus	PMID:12818200^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0008026	ATP-dependent helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002464	F
	GO:0008026	ATP-dependent helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004589	F
	GO:0008026	ATP-dependent helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011545	F
	GO:0008026	ATP-dependent helicase activity	PMID:12818200^[7]	IDA: Inferred from Direct Assay		F
	GO:0009378	four-way junction helicase activity	PMID:11433031^[3]	IDA: Inferred from Direct Assay		F
	GO:0009378	four-way junction helicase activity	PMID:12818200^[7]	IDA: Inferred from Direct Assay		F
	GO:0010165	response to X-ray	PMID:11309417^[2]	IDA: Inferred from Direct Assay		P
	GO:0016363	nuclear matrix	PMID:11309417^[2]	IDA: Inferred from Direct Assay		C
	GO:0016605	PML body	PMID:10728666^[5]	IDA: Inferred from Direct Assay		C
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012532	F
	GO:0016887	ATPase activity	PMID:17878217^[4]	IDA: Inferred from Direct Assay		F
	GO:0031297	replication fork processing	PMID:17115688^[23]	IDA: Inferred from Direct Assay		P
	GO:0031572	G2/M transition DNA damage checkpoint	PMID:11309417^[2]	NAS: Non-traceable Author Statement		P
	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018982	F
	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000127995	F
	GO:0044237	cellular metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010997	P
	GO:0045120	pronucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000127995	C
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:11781842^[6]	IDA: Inferred from Direct Assay		P
	GO:0045910	negative regulation of DNA recombination	PMID:9671747^[24]	IMP: Inferred from Mutant Phenotype		P
	GO:0045950	negative regulation of mitotic recombination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000127995	P
	GO:0046632	alpha-beta T cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000127995	P
	GO:0046641	positive regulation of alpha-beta T cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000127995	P
	GO:0048478	replication fork protection	PMID:10779560^[21]	NAS: Non-traceable Author Statement		P
	GO:0051098	regulation of binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000127995	P
	GO:0051259	protein oligomerization	PMID:10359700^[25]	IDA: Inferred from Direct Assay		P
	GO:0051276	chromosome organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000127995	P
	GO:0051782	negative regulation of cell division	PMID:11781842^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0051880	G-quadruplex DNA binding	PMID:11433031^[3]	IDA: Inferred from Direct Assay		F
colocalizes_with	GO:0000781	chromosome, telomeric region	PMID:10779560^[21]	IDA: Inferred from Direct Assay		C
colocalizes_with	GO:0016605	PML body	PMID:10779560^[21]	IDA: Inferred from Direct Assay		C
edit table

Notes

References

See Help:References for how to manage references in GONUTS. Below are a number of reviews on the role of BLM (the human homolog of RecQ in E. coli) & its role in Bloom syndrome:

Roles of the Bloom's syndrome helicase in the maintenance of genome stability. Cheok et al (2005). ^[26]

Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis. Amor-Guéret (2006). ^[27]

Functions of RecQ family helicases: possible involvement of Bloom's and Werner's syndrome gene products in guarding genome integrity during DNA replication. Enomoto (2001). ^[28]

↑ Bayart E et al. (2004) A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint. Cancer Res 64: 8954-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Bischof O et al. (2001) Regulation and localization of the Bloom syndrome protein in response to DNA damage. J Cell Biol 153: 367-80 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Mohaghegh P et al. (2001) The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases. Nucleic Acids Res 29: 2843-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Guo RB et al. (2007) Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein. Nucleic Acids Res 35: 6297-310 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Johnson FB et al. (2000) Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. Cancer Res 60: 1162-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Garkavtsev IV et al. (2001) The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control. Oncogene 20: 8276-80 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Janscak P et al. (2003) Characterization and mutational analysis of the RecQ core of the bloom syndrome protein. J Mol Biol 330: 29-42 PubMed GONUTS page
↑ Karow JK et al. (1997) The Bloom's syndrome gene product is a 3'-5' DNA helicase. J Biol Chem 272: 30611-4 PubMed GONUTS page
↑ Brosh RM Jr et al. (2000) Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs. Nucleic Acids Res 28: 2420-30 PubMed GONUTS page
↑ ^10.0 ^10.1 Opresko PL et al. (2002) Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J Biol Chem 277: 41110-9 PubMed GONUTS page
↑ Brosh RM Jr et al. (2000) Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. J Biol Chem 275: 23500-8 PubMed GONUTS page
↑ von Kobbe C et al. (2002) Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem 277: 22035-44 PubMed GONUTS page
↑ Sharma S et al. (2004) Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem 279: 9847-56 PubMed GONUTS page
↑ ^14.0 ^14.1 Lillard-Wetherell K et al. (2004) Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2. Hum Mol Genet 13: 1919-32 PubMed GONUTS page
↑ Doherty KM et al. (2005) Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases. J Biol Chem 280: 29494-505 PubMed GONUTS page
↑ Opresko PL et al. (2005) POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem 280: 32069-80 PubMed GONUTS page
↑ Pereira M et al. (2007) Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality. Mech Ageing Dev 128: 609-17 PubMed GONUTS page
↑ Suzuki H et al. (2001) The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1. Biochem Biophys Res Commun 286: 322-7 PubMed GONUTS page
↑ ^19.0 ^19.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ Kaneko H et al. (1997) BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal. Biochem Biophys Res Commun 240: 348-53 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Yankiwski V et al. (2000) Nuclear structure in normal and Bloom syndrome cells. Proc Natl Acad Sci U S A 97: 5214-9 PubMed GONUTS page
↑ ^22.0 ^22.1 Ellis NA et al. (1995) The Bloom's syndrome gene product is homologous to RecQ helicases. Cell 83: 655-66 PubMed GONUTS page
↑ Machwe A et al. (2006) The Werner and Bloom syndrome proteins catalyze regression of a model replication fork. Biochemistry 45: 13939-46 PubMed GONUTS page
↑ Yamagata K et al. (1998) Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases. Proc Natl Acad Sci U S A 95: 8733-8 PubMed GONUTS page
↑ Karow JK et al. (1999) Oligomeric ring structure of the Bloom's syndrome helicase. Curr Biol 9: 597-600 PubMed GONUTS page
↑ Cheok CF et al. (2005) Roles of the Bloom's syndrome helicase in the maintenance of genome stability. Biochem Soc Trans 33: 1456-9 PubMed GONUTS page
↑ Amor-Guéret M (2006) Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis. Cancer Lett 236: 1-12 PubMed GONUTS page
↑ Enomoto T (2001) Functions of RecQ family helicases: possible involvement of Bloom's and Werner's syndrome gene products in guarding genome integrity during DNA replication. J Biochem 129: 501-7 PubMed GONUTS page

[PMID:15604258-0] Bayart E et al. (2004) A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint. Cancer Res 64: 8954-9 PubMed GONUTS page

[PMID:11309417-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Bischof O et al. (2001) Regulation and localization of the Bloom syndrome protein in response to DNA damage. J Cell Biol 153: 367-80 PubMed GONUTS page

[PMID:11433031-2] 3.0 ^3.1 ^3.2 Mohaghegh P et al. (2001) The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases. Nucleic Acids Res 29: 2843-9 PubMed GONUTS page

[PMID:17878217-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Guo RB et al. (2007) Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein. Nucleic Acids Res 35: 6297-310 PubMed GONUTS page

[PMID:10728666-4] 5.0 ^5.1 ^5.2 ^5.3 Johnson FB et al. (2000) Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. Cancer Res 60: 1162-7 PubMed GONUTS page

[PMID:11781842-5] 6.0 ^6.1 ^6.2 Garkavtsev IV et al. (2001) The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control. Oncogene 20: 8276-80 PubMed GONUTS page

[PMID:12818200-6] 7.0 ^7.1 ^7.2 ^7.3 Janscak P et al. (2003) Characterization and mutational analysis of the RecQ core of the bloom syndrome protein. J Mol Biol 330: 29-42 PubMed GONUTS page

[PMID:9388193-7] Karow JK et al. (1997) The Bloom's syndrome gene product is a 3'-5' DNA helicase. J Biol Chem 272: 30611-4 PubMed GONUTS page

[PMID:10871376-8] Brosh RM Jr et al. (2000) Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs. Nucleic Acids Res 28: 2420-30 PubMed GONUTS page

[PMID:12181313-9] 10.0 ^10.1 Opresko PL et al. (2002) Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J Biol Chem 277: 41110-9 PubMed GONUTS page

[PMID:10825162-10] Brosh RM Jr et al. (2000) Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. J Biol Chem 275: 23500-8 PubMed GONUTS page

[PMID:11919194-11] von Kobbe C et al. (2002) Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem 277: 22035-44 PubMed GONUTS page

[PMID:14688284-12] Sharma S et al. (2004) Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem 279: 9847-56 PubMed GONUTS page

[PMID:15229185-13] 14.0 ^14.1 Lillard-Wetherell K et al. (2004) Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2. Hum Mol Genet 13: 1919-32 PubMed GONUTS page

[PMID:15965237-14] Doherty KM et al. (2005) Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases. J Biol Chem 280: 29494-505 PubMed GONUTS page

[PMID:16030011-15] Opresko PL et al. (2005) POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem 280: 32069-80 PubMed GONUTS page

[PMID:17961633-16] Pereira M et al. (2007) Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality. Mech Ageing Dev 128: 609-17 PubMed GONUTS page

[PMID:11500040-17] Suzuki H et al. (2001) The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1. Biochem Biophys Res Commun 286: 322-7 PubMed GONUTS page

[PMID:18029348-18] 19.0 ^19.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:9388480-19] Kaneko H et al. (1997) BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal. Biochem Biophys Res Commun 240: 348-53 PubMed GONUTS page

[PMID:10779560-20] 21.0 ^21.1 ^21.2 ^21.3 Yankiwski V et al. (2000) Nuclear structure in normal and Bloom syndrome cells. Proc Natl Acad Sci U S A 97: 5214-9 PubMed GONUTS page

[PMID:7585968-21] 22.0 ^22.1 Ellis NA et al. (1995) The Bloom's syndrome gene product is homologous to RecQ helicases. Cell 83: 655-66 PubMed GONUTS page

[PMID:17115688-22] Machwe A et al. (2006) The Werner and Bloom syndrome proteins catalyze regression of a model replication fork. Biochemistry 45: 13939-46 PubMed GONUTS page

[PMID:9671747-23] Yamagata K et al. (1998) Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases. Proc Natl Acad Sci U S A 95: 8733-8 PubMed GONUTS page

[PMID:10359700-24] Karow JK et al. (1999) Oligomeric ring structure of the Bloom's syndrome helicase. Curr Biol 9: 597-600 PubMed GONUTS page

[PMID:16246145-25] Cheok CF et al. (2005) Roles of the Bloom's syndrome helicase in the maintenance of genome stability. Biochem Soc Trans 33: 1456-9 PubMed GONUTS page

[PMID:15950375-26] Amor-Guéret M (2006) Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis. Cancer Lett 236: 1-12 PubMed GONUTS page

[PMID:11275547-27] Enomoto T (2001) Functions of RecQ family helicases: possible involvement of Bloom's and Werner's syndrome gene products in guarding genome integrity during DNA replication. J Biochem 129: 501-7 PubMed GONUTS page

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HUMAN:BLM

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