GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:B2L10
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | BCL2L10 (synonyms: BCLB) | |
| Protein Name(s) | Bcl-2-like protein 10
Bcl2-L-10 Anti-apoptotic protein NrH Apoptosis regulator Bcl-B | |
| External Links | ||
| UniProt | Q9HD36 | |
| EMBL | AF285092 AF326964 AJ458330 AC023906 BC093826 BC093828 BC104442 BC104443 | |
| RefSeq | NP_065129.1 | |
| UniGene | Hs.283672 | |
| PDB | 4B4S | |
| PDBsum | 4B4S | |
| ProteinModelPortal | Q9HD36 | |
| SMR | Q9HD36 | |
| BioGrid | 115334 | |
| IntAct | Q9HD36 | |
| MINT | MINT-193288 | |
| STRING | 9606.ENSP00000260442 | |
| BindingDB | Q9HD36 | |
| ChEMBL | CHEMBL5988 | |
| PhosphoSite | Q9HD36 | |
| DMDM | 23396469 | |
| PaxDb | Q9HD36 | |
| PRIDE | Q9HD36 | |
| Ensembl | ENST00000260442 | |
| GeneID | 10017 | |
| KEGG | hsa:10017 | |
| UCSC | uc002abq.3 | |
| CTD | 10017 | |
| GeneCards | GC15M052401 | |
| HGNC | HGNC:993 | |
| HPA | HPA042222 | |
| MIM | 606910 | |
| neXtProt | NX_Q9HD36 | |
| PharmGKB | PA25304 | |
| eggNOG | NOG46553 | |
| GeneTree | ENSGT00640000091607 | |
| HOGENOM | HOG000059275 | |
| HOVERGEN | HBG050646 | |
| InParanoid | Q9HD36 | |
| KO | K18451 | |
| OrthoDB | EOG7Q5HFF | |
| PhylomeDB | Q9HD36 | |
| TreeFam | TF334762 | |
| GeneWiki | BCL2L10 | |
| GenomeRNAi | 10017 | |
| NextBio | 37845 | |
| PRO | PR:Q9HD36 | |
| Proteomes | UP000005640 | |
| Bgee | Q9HD36 | |
| CleanEx | HS_BCL2L10 | |
| ExpressionAtlas | Q9HD36 | |
| Genevestigator | Q9HD36 | |
| GO | GO:0005829 GO:0016021 GO:0016020 GO:0005741 GO:0005739 GO:0031965 GO:0046982 GO:0042803 GO:0006919 GO:0097192 GO:0007292 GO:0008630 GO:0043066 GO:2001240 GO:2001243 GO:0007283 | |
| InterPro | IPR002475 IPR020717 IPR020726 IPR026298 | |
| PANTHER | PTHR11256 | |
| Pfam | PF00452 | |
| PROSITE | PS50062 PS01080 PS01258 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0089720 |
caspase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097192 |
extrinsic apoptotic signaling pathway in absence of ligand |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101769 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88138 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1330841 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0029131 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88139 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR020717 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007292 |
female gamete generation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kim, JH et al. (2009) HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death. Cell. Physiol. Biochem. 23 43-52 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Ke, N et al. (2001) Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak. J. Biol. Chem. 276 12481-4 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Song, Q et al. (1999) Boo, a novel negative regulator of cell death, interacts with Apaf-1. EMBO J. 18 167-78 PubMed GONUTS page
- ↑ Inohara, N et al. (1998) Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death. J. Biol. Chem. 273 32479-86 PubMed GONUTS page
a
e
i
m
n
p
