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Category:GO:0031052 ! programmed DNA elimination by chromosome breakage
name: programmed DNA elimination by chromosome breakage
namespace: biological_process
def: "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns, PMID:15956677, PMID:25303953, PMID:32165395]
comment: Note that this term refers to breakage of chromosomes during normal DNA well characterized in ciliates but also present in many vertebrates; it is not to be used for DNA damage or other abnormal occurrences.
synonym: "chromosome breakage" RELATED []
is_a: GO:0031049 ! programmed DNA elimination
AmiGO
<GOterm>GO:0031052</GOterm>
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