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Category:GO:0030060 ! L-malate dehydrogenase activity
name: L-malate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]
subset: gosubset_prok
synonym: "(S)-malate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37]
synonym: "L-malate-NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37]
synonym: "malate (NAD) dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "malic acid dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "malic dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "MDH" RELATED [EC:1.1.1.37]
synonym: "NAD-dependent malate dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-dependent malic dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-L-malate dehydrogenase activity" EXACT []
synonym: "NAD-linked malate dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-malate dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-malic dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-specific malate dehydrogenase activity" EXACT [EC:1.1.1.37]
xref: EC:1.1.1.37
xref: MetaCyc:MALATE-DEH-RXN
xref: Reactome:REACT_102397 "malate + NAD+ <=> oxaloacetate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_104572 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_105207 "malate + NAD+ <=> oxaloacetate + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_106078 "malate + NAD+ <=> oxaloacetate + NADH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_106462 "malate + NAD+ <=> oxaloacetate + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_106744 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Canis familiaris"
xref: Reactome:REACT_109070 "malate + NAD+ <=> oxaloacetate + NADH + H+, Sus scrofa"
xref: Reactome:REACT_11169 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Homo sapiens"
xref: Reactome:REACT_11216 "malate + NAD+ <=> oxaloacetate + NADH + H+, Homo sapiens"
xref: Reactome:REACT_115649 "malate + NAD+ <=> oxaloacetate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_115954 "malate + NAD+ <=> oxaloacetate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_116085 "oxaloacetate + NADH + H+ <=> malate + NAD+, Gallus gallus"
xref: Reactome:REACT_2172 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Homo sapiens"
xref: Reactome:REACT_29462 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Escherichia coli"
xref: Reactome:REACT_31106 "malate + NAD+ <=> oxaloacetate + NADH + H+, Mus musculus"
xref: Reactome:REACT_31242 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Danio rerio"
xref: Reactome:REACT_31405 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Mus musculus"
xref: Reactome:REACT_31952 "malate + NAD+ <=> oxaloacetate + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_33338 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Taeniopygia guttata"
xref: Reactome:REACT_34002 "malate + NAD+ <=> oxaloacetate + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_53903 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Bos taurus"
xref: Reactome:REACT_77697 "malate + NAD+ <=> oxaloacetate + NADH + H+, Danio rerio"
xref: Reactome:REACT_79868 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_80013 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_80217 "malate + NAD+ <=> oxaloacetate + NADH + H+, Canis familiaris"
xref: Reactome:REACT_80842 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Escherichia coli"
xref: Reactome:REACT_80996 "malate + NAD+ <=> oxaloacetate + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_81948 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_84788 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Gallus gallus"
xref: Reactome:REACT_86359 "malate + NAD+ <=> oxaloacetate + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_87130 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Canis familiaris"
xref: Reactome:REACT_89843 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Bos taurus"
xref: Reactome:REACT_91106 "malate + NAD+ <=> oxaloacetate + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_91301 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Rattus norvegicus"
xref: Reactome:REACT_92377 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_94018 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Danio rerio"
xref: Reactome:REACT_94356 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Xenopus tropicalis"
xref: Reactome:REACT_95217 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Drosophila melanogaster"
xref: Reactome:REACT_95270 "malate + NAD+ <=> oxaloacetate + NADH + H+, Oryza sativa"
xref: Reactome:REACT_96050 "malate + NAD+ <=> oxaloacetate + NADH + H+, Bos taurus"
xref: Reactome:REACT_97987 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Caenorhabditis elegans"
xref: Reactome:REACT_98367 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_98640 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Mus musculus"
xref: Reactome:REACT_98721 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Schizosaccharomyces pombe"
xref: Reactome:REACT_99734 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Drosophila melanogaster"
xref: RHEA:21435
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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