Category:GO:0019907 ! cyclin-dependent protein kinase activating kinase holoenzyme complex

name: cyclin-dependent protein kinase activating kinase holoenzyme complex
namespace: cellular_component
def: "A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH." [GOC:bhm, PMID:8752210]
synonym: "CAK complex" EXACT []
synonym: "CDK-activating kinase complex" EXACT []
is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex
is_a: GO:0150005 ! enzyme activator complex

AmiGO <GOterm>GO:0019907</GOterm>
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