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Category:GO:0004362 ! glutathione-disulfide reductase activity
name: glutathione-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732]
comment: Note that this function was formerly EC:1.6.4.2.
subset: gosubset_prok
synonym: "glutathione reductase (NADPH) activity" EXACT []
synonym: "glutathione reductase activity" EXACT []
synonym: "glutathione S-reductase activity" EXACT [EC:1.8.1.7]
synonym: "glutathione-disulphide reductase activity" EXACT []
synonym: "glutathione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.7]
synonym: "GSH reductase activity" EXACT [EC:1.8.1.7]
synonym: "GSSG reductase activity" EXACT [EC:1.8.1.7]
synonym: "NADPH-glutathione reductase activity" EXACT [EC:1.8.1.7]
synonym: "NADPH-GSSG reductase activity" EXACT [EC:1.8.1.7]
synonym: "NADPH:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.1.7]
synonym: "oxidized glutathione reduction" RELATED []
xref: EC:1.8.1.7
xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN
xref: Reactome:REACT_100755 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Plasmodium falciparum"
xref: Reactome:REACT_105351 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Mus musculus"
xref: Reactome:REACT_106052 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Escherichia coli"
xref: Reactome:REACT_107331 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Bos taurus"
xref: Reactome:REACT_108894 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Xenopus tropicalis"
xref: Reactome:REACT_2220 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Homo sapiens"
xref: Reactome:REACT_31135 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Canis familiaris"
xref: Reactome:REACT_33636 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Sus scrofa"
xref: Reactome:REACT_34766 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Dictyostelium discoideum"
xref: Reactome:REACT_82516 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Rattus norvegicus"
xref: Reactome:REACT_87466 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Mycobacterium tuberculosis"
xref: Reactome:REACT_91212 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Schizosaccharomyces pombe"
xref: Reactome:REACT_91373 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Danio rerio"
xref: Reactome:REACT_93897 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Caenorhabditis elegans"
xref: Reactome:REACT_95299 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Saccharomyces cerevisiae"
xref: Reactome:REACT_95410 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Gallus gallus"
xref: Reactome:REACT_98360 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Taeniopygia guttata"
xref: RHEA:11743
is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor
AmiGO
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