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HUMAN:CAMP

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0001934

positive regulation of protein phosphorylation

PMID:24085296

ECO:0000266

UniProtKB:

P

Figure 1: Fisetin potentiation of HCN2 channels resembled the channel's regulation by cAMP, thereby suggesting that fisetin and cAMP may use similar mechanisms to stabilize the channel's open state

complete
CACAO 10706

public

GO:0042742

defense response to bacterium

PMID:16020269

ECO:0000314

P

The human cathelicidin antimicrobial peptide can be cleaved into two peptides, one of which being the antibacterial peptide LL-37. The antibacterial activity of LL-37 against Pseudomonas Aeruginosa, Staphylococcus Aureus, and Staphylococcus Epidermidis was tested using an antibacterial assay. The results showed that at 100 μg/ml, LL-37 was completely bactericidal for all strains of PA, as shown in Figure 2. LL-37 also showed potent bactericidal activity against SA and SE with EC50 values being 1.6 ± 1.5 (n = 3) and 1.31.9 (n 3) μg/ml, respectively.

complete
CACAO 12385

public

GO:0051873

killing by host of symbiont cells

PMID:16020269

ECO:0000314

P

Human cathelicidin antimicrobial peptide has the ability to kill the cells of other organisms. It can be cleaved into two peptides, one of which being the antibacterial peptide LL-37. The antibacterial activity of LL-37 against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis was tested using an antibacterial assay. The results showed that at 100 μg/ml, LL-37 was completely bactericidal for all strains of Pseudomonas aeruginosa (Figure 2). LL-37 also showed potent bactericidal activity against Staphylococcus aureus and Staphylococcus epidermidis with EC50 values being 1.6 ± 1.5 (n = 3) and 1.31.9 (n 3) μg/ml, respectively (Figure 2).

complete
CACAO 12515

public

GO:0002376

immune system process

PMID:16020269

ECO:0000314

P

Human cathelicidin antimicrobial peptide plays a role in immune system processes. It can be cleaved into two peptides, one of which being the antibacterial peptide LL-37. The antibacterial immune activity of LL-37 against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis was tested using an antibacterial assay. The results showed that at 100 μg/ml, LL-37 was completely bactericidal for all strains of Pseudomonas aeruginosa (Figure 2). LL-37 also showed potent bactericidal activity against Staphylococcus aureus and Staphylococcus epidermidis with EC50 values being 1.6 ± 1.5 (n = 3) and 1.31.9 (n 3) μg/ml, respectively (Figure 2).

complete
CACAO 12516

public

GO:0016045

detection of bacterium

PMID:16020269

ECO:0000314

P

Human cathelicidin antimicrobial peptide has the ability to detect bacterial cells and express antibacterial activity against them. It can be cleaved into two peptides, one of which being the antibacterial peptide LL-37. The antibacterial activity of LL-37 against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis was tested using an antibacterial assay. The results showed that at 100 μg/ml, LL-37 was completely bactericidal for all strains of Pseudomonas aeruginosa (Figure 2). LL-37 also showed potent bactericidal activity against Staphylococcus aureus and Staphylococcus epidermidis with EC50 values being 1.6 ± 1.5 (n = 3) and 1.31.9 (n 3) μg/ml, respectively (Figure 2).

complete
CACAO 12517

protected

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:12860195

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0042581

specific granule

PMID:12759353

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000775)

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:12759353

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0006530)

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:18714013

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0006530)

Seeded From UniProt

complete

protected

part_of

GO:0070062

extracellular exosome

PMID:23533145

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0070062

extracellular exosome

PMID:19056867

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

protected

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:12860195

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0000317)

Seeded From UniProt

complete

protected

involved_in

GO:0019731

antibacterial humoral response

PMID:12860195

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0000317)

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:12860195

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0000317)

Seeded From UniProt

complete

protected

involved_in

GO:0002227

innate immune response in mucosa

PMID:12860195

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0000317)

Seeded From UniProt

complete

protected

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108443
PANTHER:PTN000024620
UniProtKB:P49913

P

Seeded From UniProt

complete

protected

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108443
PANTHER:PTN000024620
RGD:1559878
UniProtKB:P22226
UniProtKB:P49913
UniProtKB:Q2IAL6
UniProtKB:Q2IAL7
UniProtKB:Q6QLQ5
UniProtKB:R4GJF1

P

Seeded From UniProt

complete

protected

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108443
PANTHER:PTN000024620
RGD:1559878
UniProtKB:P22226
UniProtKB:Q2IAL6
UniProtKB:Q2IAL7
UniProtKB:Q6QLQ5
UniProtKB:R4GJF1

P

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108443
PANTHER:PTN000024620

P

Seeded From UniProt

complete

protected

part_of

GO:0042581

specific granule

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108443
PANTHER:PTN000024620
UniProtKB:P49913

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:105983
PANTHER:PTN000024620
RGD:1559878
UniProtKB:P49913

C

Seeded From UniProt

complete

protected

enables

GO:0001530

lipopolysaccharide binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000024620
UniProtKB:Q2IAL7
UniProtKB:Q6QLQ5

F

Seeded From UniProt

complete

protected

involved_in

GO:0051873

killing by host of symbiont cells

PMID:16177355

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0044140

negative regulation of growth of symbiont on or near host surface

PMID:16177355

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042742

defense response to bacterium

PMID:21115716

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:21115716

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001894
InterPro:IPR018216

C

Seeded From UniProt

complete

protected

involved_in

GO:0006952

defense response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001894
InterPro:IPR018216

P

Seeded From UniProt

complete

protected

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR022746

P

Seeded From UniProt

complete

protected

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:7529412

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

PMID:7529412

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0019731

antibacterial humoral response

PMID:7529412

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:7529412

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:7529412

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:12759353

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:9182550

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:17012259

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:14978112

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:20209079

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035821

modification of morphology or physiology of other organism

PMID:23537644

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:23537644

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:23537644

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:23537644

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2000484

positive regulation of interleukin-8 secretion

PMID:14978112

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000312)

Seeded From UniProt

complete

protected

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:14978112

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001878

response to yeast

PMID:14978112

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0019732

antifungal humoral response

PMID:14978112

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:14978112

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0019731

antibacterial humoral response

PMID:14978112

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

PMID:14978112

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:14978112

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001089)

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

PMID:12759353

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0000996)

Seeded From UniProt

complete

protected

involved_in

GO:0019731

antibacterial humoral response

PMID:12759353

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:12759353

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:12759353

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0002544

chronic inflammatory response

PMID:9182550

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0000014)

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:20421939

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:20421939

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051838

cytolysis by host of symbiont cells

PMID:20421939

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

PMID:9182550

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0000014)

Seeded From UniProt

complete

protected

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:9182550

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0000014)

Seeded From UniProt

complete

protected

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:17012259

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0000014)

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

PMID:17012259

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0000014)

Seeded From UniProt

complete

protected

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:20209079

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0019731

antibacterial humoral response

PMID:20209079

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:20209079

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

PMID:20209079

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0019732

antifungal humoral response

PMID:20209079

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001878

response to yeast

PMID:20209079

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042742

defense response to bacterium

PMID:8681941

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:1904724

tertiary granule lumen

Reactome:R-HSA-6798745

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0035580

specific granule lumen

Reactome:R-HSA-6798749

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0019730

antimicrobial humoral response

Reactome:R-HSA-6803157

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6801687
Reactome:R-HSA-6798749
Reactome:R-HSA-6798745
Reactome:R-HSA-1222685

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

protected

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0044

P

Seeded From UniProt

complete




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