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HUMAN:PRDX4

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0004601

peroxidase activity

PMID:25656995

ECO:0000314

F

Fig.1 pathway of Peroxiredoxins shown

complete
CACAO 10637

protected

part_of

GO:0070062

extracellular exosome

PMID:19199708

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21630459

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

protected

involved_in

GO:0045454

cell redox homeostasis

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040309
MGI:MGI:1859815
PANTHER:PTN000073874
PomBase:SPCC576.03c
SGD:S000002861
SGD:S000004490
UniProtKB:P9WQB7

P

Seeded From UniProt

complete

protected

involved_in

GO:0042744

hydrogen peroxide catabolic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000189947
FB:FBgn0040308
FB:FBgn0040309
MGI:MGI:109486
PANTHER:PTN000073874
PomBase:SPCC576.03c
UniProtKB:Q06830
UniProtKB:Q6ER94

P

Seeded From UniProt

complete

protected

enables

GO:0008379

thioredoxin peroxidase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000189947
FB:FBgn0040308
FB:FBgn0040309
PANTHER:PTN000073874
PomBase:SPCC576.03c
SGD:S000002861
SGD:S000004490
UniProtKB:P32119
UniProtKB:Q06830
UniProtKB:Q8I5Q6
UniProtKB:Q8IL80

F

Seeded From UniProt

complete

protected

involved_in

GO:0006979

response to oxidative stress

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040308
FB:FBgn0040309
MGI:MGI:99523
PANTHER:PTN000073874
RGD:3838
RGD:620039
UniProtKB:P32119
UniProtKB:Q8I5Q6
UniProtKB:Q8IL80

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11384
FB:FBgn0040308
FB:FBgn0040309
MGI:MGI:1859815
PANTHER:PTN000073874
RGD:3838
RGD:620039
SGD:S000004490
UniProtKB:Q8IL80

C

Seeded From UniProt

complete

protected

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040308
MGI:MGI:1859815
PANTHER:PTN000841180

C

Seeded From UniProt

complete

protected

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016209

P

Seeded From UniProt

complete

protected

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0051920

P

Seeded From UniProt

complete

protected

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008379

P

Seeded From UniProt

complete

protected

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008379

P

Seeded From UniProt

complete

protected

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016209

P

Seeded From UniProt

complete

protected

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004601

P

Seeded From UniProt

complete

protected

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0051920

P

Seeded From UniProt

complete

protected

involved_in

GO:2000255

negative regulation of male germ cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

protected

involved_in

GO:0072593

reactive oxygen species metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

protected

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

protected

involved_in

GO:0045454

cell redox homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

F

Seeded From UniProt

complete

protected

involved_in

GO:0030198

extracellular matrix organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

protected

involved_in

GO:0022417

protein maturation by protein folding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

protected

involved_in

GO:0019471

4-hydroxyproline metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

protected

involved_in

GO:0008584

male gonad development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

protected

involved_in

GO:0007283

spermatogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

C

Seeded From UniProt

complete

protected

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

C

Seeded From UniProt

complete

protected

part_of

GO:0005790

smooth endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0V5
ensembl:ENSRNOP00000005014

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0V5
ensembl:ENSRNOP00000005014

C

Seeded From UniProt

complete

protected

enables

GO:0016209

antioxidant activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000866

F

Seeded From UniProt

complete

protected

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000866

F

Seeded From UniProt

complete

protected

involved_in

GO:0045454

cell redox homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013766

P

Seeded From UniProt

complete

protected

enables

GO:0051920

peroxiredoxin activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019479

F

Seeded From UniProt

complete

protected

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000866
InterPro:IPR019479

P

Seeded From UniProt

complete

protected

enables

GO:0051920

peroxiredoxin activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.11.1.15

F

Seeded From UniProt

complete

protected

enables

GO:0008379

thioredoxin peroxidase activity

PMID:9388242

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007252

I-kappaB phosphorylation

PMID:9388242

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:1904813

ficolin-1-rich granule lumen

Reactome:R-HSA-6800434

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0034774

secretory granule lumen

Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6800434
Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

protected

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

complete

protected

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

protected

enables

GO:0004601

peroxidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0575

F

Seeded From UniProt

complete

protected

enables

GO:0016209

antioxidant activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0049

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete



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