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TableEdit
ECO44:PIC
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Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status | |
---|---|---|---|---|---|---|---|---|---|---|---|
protected |
enables |
GO:0004175 |
endopeptidase activity |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR030396 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0004252 |
serine-type endopeptidase activity |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000710 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0006508 |
proteolysis |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000710 |
P |
Seeded From UniProt |
complete | |
public |
GO:0045916 |
negative regulation of complement activation |
PMID:25583166 |
ECO:0000314 |
P |
Figure 1 shows that Pic inhibits all three complement cascades, as shown by the decrease in deposition of C4b with anti-C4 antibodies. Figure 2 shows that Pic cleaves complement proteins. Figure 3 shows that Pic present in the supernatant of E.coli is also able to cleave purified complement proteins. Figure 4 shows that it cleaves complement proteins found in human serum |
complete | ||||
protected |
part_of |
GO:0019867 |
outer membrane |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR006315 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0008236 |
serine-type peptidase activity |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0720 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0016021 |
integral component of membrane |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0812 |
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0042597 |
periplasmic space |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0574 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0016787 |
hydrolase activity |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0378 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0009405 |
pathogenesis |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0843 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0016020 |
membrane |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0472 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0008233 |
peptidase activity |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0645 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005576 |
extracellular region |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0964 |
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0006508 |
proteolysis |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0645 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0009279 |
cell outer membrane |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0998 |
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0009986 |
cell surface |
GO_REF:0000039 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-SubCell:SL-0310 |
C |
Seeded From UniProt |
complete |
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