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HUMAN:DNA2

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0006260

DNA replication

PMID:7788527

ECO:0000314

P

Figure 2 shows the expression patterns of representative clones.

complete
CACAO 9455

protected

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:23604072

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6ZQJ5

C

Seeded From UniProt

complete

protected

involved_in

GO:1902990

mitotic telomere maintenance via semi-conservative replication

PMID:23604072

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6ZQJ5

P

Seeded From UniProt

complete

protected

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

PMID:23604072

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6ZQJ5

P

part_of:(GO:1902990)

Seeded From UniProt

complete

protected

involved_in

GO:0000723

telomere maintenance

PMID:23604072

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6ZQJ5

P

Seeded From UniProt

complete

protected

involved_in

GO:0045740

positive regulation of DNA replication

PMID:18995831

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043504

mitochondrial DNA repair

PMID:19487465

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0043142

single-stranded DNA-dependent ATPase activity

PMID:16595800

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0043142

single-stranded DNA-dependent ATPase activity

PMID:16595799

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0043139

5'-3' DNA helicase activity

PMID:20019387

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0043137

DNA replication, removal of RNA primer

PMID:18995831

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0042645

mitochondrial nucleoid

PMID:19487465

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0033567

DNA replication, Okazaki fragment processing

PMID:22570407

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0017108

5'-flap endonuclease activity

PMID:20019387

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0017108

5'-flap endonuclease activity

PMID:16595800

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0017108

5'-flap endonuclease activity

PMID:16595799

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0017108

5'-flap endonuclease activity

PMID:22570407

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0017108

5'-flap endonuclease activity

PMID:18995831

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0016890

site-specific endodeoxyribonuclease activity, specific for altered base

PMID:18995831

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0006284

base-excision repair

PMID:18995831

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006264

mitochondrial DNA replication

PMID:19487465

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006264

mitochondrial DNA replication

PMID:18995831

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006260

DNA replication

PMID:22570476

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

colocalizes_with

GO:0005760

gamma DNA polymerase complex

PMID:18995831

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:19487465

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0004518

nuclease activity

PMID:21325134

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003678

DNA helicase activity

PMID:16595800

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

NOT|enables

GO:0003678

DNA helicase activity

PMID:16595799

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

PMID:20019387

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

PMID:22570407

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0000729

DNA double-strand break processing

PMID:21325134

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000076

DNA replication checkpoint

PMID:22570476

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071932

replication fork reversal

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000094675
PomBase:SPBC16D10.04c

P

Seeded From UniProt

complete

protected

enables

GO:0017108

5'-flap endonuclease activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2443732
PANTHER:PTN000094675
SGD:S000001207
UniProtKB:P51530

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000094675
PomBase:SPBC16D10.04c
SGD:S000001207

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000094675
SGD:S000001207
UniProtKB:A0A1P8ASY1
UniProtKB:P51530

C

Seeded From UniProt

complete

protected

enables

GO:0003723

RNA binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000094509
UniProtKB:Q92900
UniProtKB:Q9HCE1

F

Seeded From UniProt

complete

protected

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2443732
PANTHER:PTN000094675
PomBase:SPBC16D10.04c
SGD:S000001207

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003678

P

Seeded From UniProt

complete

protected

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003678

P

Seeded From UniProt

complete

protected

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0043139

P

Seeded From UniProt

complete

protected

involved_in

GO:1902990

mitotic telomere maintenance via semi-conservative replication

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6ZQJ5
ensembl:ENSMUSP00000115750

P

Seeded From UniProt

complete

protected

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6ZQJ5
ensembl:ENSMUSP00000115750

P

Seeded From UniProt

complete

protected

enables

GO:0017108

5'-flap endonuclease activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6ZQJ5
ensembl:ENSMUSP00000115750

F

Seeded From UniProt

complete

protected

part_of

GO:0000784

nuclear chromosome, telomeric region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6ZQJ5
ensembl:ENSMUSP00000115750

C

Seeded From UniProt

complete

protected

involved_in

GO:0000723

telomere maintenance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6ZQJ5
ensembl:ENSMUSP00000115750

P

Seeded From UniProt

complete

protected

enables

GO:0017108

5'-flap endonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026851

F

Seeded From UniProt

complete

protected

involved_in

GO:0033567

DNA replication, Okazaki fragment processing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026851

P

Seeded From UniProt

complete

protected

enables

GO:0043142

single-stranded DNA-dependent ATPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026851

F

Seeded From UniProt

complete

protected

involved_in

GO:0044806

G-quadruplex DNA unwinding

PMID:27918544

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0090656

t-circle formation

PMID:27918544

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0016887

ATPase activity

PMID:18995831

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004386

helicase activity

PMID:18995831

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032201

telomere maintenance via semi-conservative replication

Reactome:R-HSA-174451
Reactome:R-HSA-174441

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

involved_in

GO:0006260

DNA replication

Reactome:R-HSA-5684887
Reactome:R-HSA-5684875

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-69144
Reactome:R-HSA-69142
Reactome:R-HSA-6799332
Reactome:R-HSA-5693620
Reactome:R-HSA-5693593
Reactome:R-HSA-5693589
Reactome:R-HSA-5693584
Reactome:R-HSA-5693580
Reactome:R-HSA-5693564
Reactome:R-HSA-5693561
Reactome:R-HSA-5693542
Reactome:R-HSA-5693539
Reactome:R-HSA-5686657
Reactome:R-HSA-5686642
Reactome:R-HSA-5686483
Reactome:R-HSA-5686469
Reactome:R-HSA-5686440
Reactome:R-HSA-5686410
Reactome:R-HSA-5685994
Reactome:R-HSA-5685985
Reactome:R-HSA-5685838
Reactome:R-HSA-5685341
Reactome:R-HSA-5685156
Reactome:R-HSA-5685011
Reactome:R-HSA-5684887
Reactome:R-HSA-5684882
Reactome:R-HSA-5684875
Reactome:R-HSA-174451
Reactome:R-HSA-174441

ECO:0000304

author statement supported by traceable reference used in manual assertion





























C

Seeded From UniProt

complete

protected

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

protected

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

protected

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

protected

involved_in

GO:0006260

DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0235

P

Seeded From UniProt

complete

protected

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0004

F

Seeded From UniProt

complete

protected

enables

GO:0004386

helicase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0347

F

Seeded From UniProt

complete

protected

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

protected

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

protected

enables

GO:0051536

iron-sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0411

F

Seeded From UniProt

complete

protected

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

protected

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

protected

enables

GO:0004519

endonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0255

F

Seeded From UniProt

complete




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