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HUMAN:TTBK2

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0004672

protein kinase activity

PMID:21548880

ECO:0000314

F

Figure 4. Cells expressing GFP-TTBK2 were treated to induce the expression of TTBK2. Flourcent imaging was performed using a confocal microscope. Mutations showed an increase in TTBK2 as well as protein kinase activity.

complete
CACAO 9373

protected

enables

GO:0019894

kinesin binding

PMID:26323690

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9WV63

F

occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

PMID:28386764

ECO:0000303

author statement without traceable support used in manual assertion

F

has_input:(UniProtKB:P10636)

Seeded From UniProt

complete

protected

involved_in

GO:1904527

negative regulation of microtubule binding

PMID:26323690

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:O00139)

Seeded From UniProt

complete

protected

involved_in

GO:0007026

negative regulation of microtubule depolymerization

PMID:26323690

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:26323690

ECO:0000314

direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:O00139)
  • negatively_regulates:(GO:0007019)
  • negatively_regulates:(GO:0008017)
  • occurs_at:(GO:0005874)

Seeded From UniProt

complete

protected

enables

GO:0004672

protein kinase activity

PMID:26323690

ECO:0000314

direct assay evidence used in manual assertion

F

has_input:(UniProtKB:O00139)

Seeded From UniProt

complete

protected

involved_in

GO:0021935

cerebellar granule cell precursor tangential migration

PMID:26323690

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UVR3

P

  • part_of:(GO:0021681)
  • part_of:(GO:0021549)

Seeded From UniProt

complete

protected

involved_in

GO:0021681

cerebellar granular layer development

PMID:26323690

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UVR3

P

Seeded From UniProt

complete

protected

involved_in

GO:0021549

cerebellum development

PMID:26323690

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UVR3

P

Seeded From UniProt

complete

protected

involved_in

GO:0030334

regulation of cell migration

PMID:26323690

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O00139

P

Seeded From UniProt

complete

protected

involved_in

GO:0000226

microtubule cytoskeleton organization

PMID:26323690

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O00139

P

regulates:(GO:0016477)

Seeded From UniProt

complete

protected

enables

GO:0048156

tau protein binding

PMID:28386764

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0050321

tau-protein kinase activity

PMID:28386764

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:1902817

negative regulation of protein localization to microtubule

PMID:26323690

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:O00139)

Seeded From UniProt

complete

protected

involved_in

GO:0060271

cilium assembly

PMID:23141541

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005814

centriole

PMID:23141541

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0035869

ciliary transition zone

PMID:23141541

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002586)

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:22664934

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001827)

Seeded From UniProt

complete

protected

involved_in

GO:0060271

cilium assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UVR3

P

Seeded From UniProt

complete

protected

part_of

GO:0036064

ciliary basal body

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UVR3

C

Seeded From UniProt

complete

protected

part_of

GO:0035869

ciliary transition zone

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UVR3

C

Seeded From UniProt

complete

protected

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:21548880

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007224

smoothened signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UVR3

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:21548880

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21548880

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21548880

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0060271

cilium assembly

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2155779
PANTHER:PTN002628896
UniProtKB:Q6IQ55

P

Seeded From UniProt

complete

protected

part_of

GO:0036064

ciliary basal body

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2155779
PANTHER:PTN002628896

C

Seeded From UniProt

complete

protected

part_of

GO:0035869

ciliary transition zone

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2155779
PANTHER:PTN002628896
UniProtKB:Q6IQ55

C

Seeded From UniProt

complete

protected

involved_in

GO:0018107

peptidyl-threonine phosphorylation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0027889
PANTHER:PTN002628885
SGD:S000002175
UniProtKB:Q5TCY1

P

Seeded From UniProt

complete

protected

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2155779
PANTHER:PTN002628885
RGD:71098
SGD:S000002175
UniProtKB:P35507
UniProtKB:P35508
UniProtKB:P48729
UniProtKB:P48730
UniProtKB:P49674
UniProtKB:P67827
UniProtKB:P78368
UniProtKB:Q5TCY1
UniProtKB:Q6IQ55
UniProtKB:Q9HCP0
UniProtKB:Q9Y6M4
ZFIN:ZDB-GENE-020419-19

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002413
FB:FBgn0015024
FB:FBgn0030384
FB:FBgn0031441
FB:FBgn0032650
FB:FBgn0037325
FB:FBgn0039908
PANTHER:PTN000225966
PomBase:SPBP35G2.05c
RGD:62045
RGD:71098
TAIR:locus:2018269
TAIR:locus:2024147
TAIR:locus:2030170
TAIR:locus:2117778
TAIR:locus:2117843
TAIR:locus:2129640
TAIR:locus:504954933
UniProtKB:C8V7X8
UniProtKB:O00311
UniProtKB:P49674
UniProtKB:Q86Y07
WB:WBGene00002202
WB:WBGene00013709
dictyBase:DDB_G0273059

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002413
FB:FBgn0015024
FB:FBgn0027889
FB:FBgn0030384
MGI:MGI:1261847
MGI:MGI:1351660
MGI:MGI:1355272
MGI:MGI:2182465
PANTHER:PTN000225966
PomBase:SPBC776.12c
RGD:62045
RGD:71098
SGD:S000000925
SGD:S000002175
SGD:S000006125
TAIR:locus:2024147
TAIR:locus:2030170
TAIR:locus:2117778
TAIR:locus:2117843
TAIR:locus:2129640
UniProtKB:A0A0B4KHL4
UniProtKB:C8V7X8
UniProtKB:C8VHB6
UniProtKB:O00311
UniProtKB:Q6IQ55
UniProtKB:Q6K9N1
UniProtKB:Q852L0
UniProtKB:Q86Y07
UniProtKB:Q8IV63
UniProtKB:Q99986
WB:WBGene00002202
WB:WBGene00017895
dictyBase:DDB_G0273059

C

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002413
FB:FBgn0015024
FB:FBgn0031441
FB:FBgn0032650
FB:FBgn0037325
MGI:MGI:1261847
MGI:MGI:1917172
MGI:MGI:2155779
PANTHER:PTN002628885
PomBase:SPAC23C4.12
PomBase:SPBC1347.06c
PomBase:SPBC3H7.15
PomBase:SPBC776.12c
RGD:62045
RGD:621404
RGD:621407
RGD:621408
RGD:71031
RGD:71098
SGD:S000001177
SGD:S000002175
SGD:S000005098
SGD:S000006125
TAIR:locus:2091566
TAIR:locus:2117843
TAIR:locus:2121338
TAIR:locus:2129640
TAIR:locus:2130290
UniProtKB:A0A0B4KHL4
UniProtKB:P35507
UniProtKB:P35508
UniProtKB:P48729
UniProtKB:P48730
UniProtKB:P49674
UniProtKB:P67827
UniProtKB:P78368
UniProtKB:Q6IQ55
UniProtKB:Q86Y07
UniProtKB:Q8IHZ9
UniProtKB:Q99986
UniProtKB:Q9HCP0
UniProtKB:Q9Y6M4
dictyBase:DDB_G0273059

F

Seeded From UniProt

complete

protected

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

P

Seeded From UniProt

complete

protected

enables

GO:0051010

microtubule plus-end binding

PMID:26323690

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0050321

tau-protein kinase activity

PMID:26323690

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

has_input:(UniProtKB:P10636)

Seeded From UniProt

complete

protected

involved_in

GO:0097711

ciliary basal body-plasma membrane docking

Reactome:R-HSA-5620912

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-HSA-5638009
Reactome:R-HSA-5626699
Reactome:R-HSA-5626681
Reactome:R-HSA-5626228
Reactome:R-HSA-5626227
Reactome:R-HSA-5617816

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

protected

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

protected

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

protected

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

protected

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

protected

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

protected

involved_in

GO:0030030

cell projection organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0970

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

protected

part_of

GO:0005929

cilium

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0969
UniProtKB-SubCell:SL-0066

C

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

protected

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

protected

part_of

GO:0005814

centriole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0046

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete



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