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PMID:20573232
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| Citation |
Hong, SB, Oh, H, Valera, VA, Stull, J, Ngo, DT, Baba, M, Merino, MJ, Linehan, WM and Schmidt, LS (2010) Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling. Mol. Cancer 9:160 |
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| Abstract |
Germline mutations in the FLCN gene are responsible for the development of fibrofolliculomas, lung cysts and renal neoplasia in Birt-Hogg-Dube' (BHD) syndrome. The encoded protein folliculin (FLCN) is conserved across species but contains no classic motifs or domains and its function remains unknown. Somatic mutations or loss of heterozygosity in the remaining wild type copy of the FLCN gene have been found in renal tumors from BHD patients suggesting that FLCN is a classic tumor suppressor gene. |
| Links |
PubMed PMC2907329 Online version:10.1186/1476-4598-9-160 |
| Keywords |
Animals; Cell Line, Tumor; Gene Expression Regulation/physiology; Genes, Tumor Suppressor; Genetic Vectors; Humans; Kidney Neoplasms/genetics; Kidney Neoplasms/pathology; Lentivirus/genetics; Mice; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/physiology; Signal Transduction/physiology; Transforming Growth Factor beta/metabolism; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/physiology |
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