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MOUSE:NLRC3

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0032720

negative regulation of tumor necrosis factor production

PMID:22863753

ECO:0000315

P

With knockout mice, Figure 4c graph 1 shows that with stimulation of the TLR on the cell that there is an increased production of the TNF when compared to the WT.

complete
CACAO 9191

public

GO:0032715

negative regulation of interleukin-6 production

PMID:22863753

ECO:0000315

P

Figure 4c graph 2. In knockout mice of the NLCR3 protein then in response to stimulation of TLR then there is an increased amount of IL-6 made when compared to the WT cell.

complete
CACAO 9192

public

GO:0032695

negative regulation of interleukin-12 production

PMID:22863753

ECO:0000315

P

Figure 4c graph 4. With knockout mice of NLRC3 protein when TLR was stimulated there was an increased production of IL-12 when compared to the WT thus indicating that NLRC3 negatively regulates the IL-12 production.

complete
CACAO 9193

public

GO:0032691

negative regulation of interleukin-1 beta production

PMID:22863753

ECO:0000315

P

With knockdown of protein NLRC3 in mice, figure 4c graph 3 indicates that these mice upon TLR stimulation resulted in increased production of IL-1 beta when compared to the WT mice TLR response. This indicates that NLRC3 negatively regulates the production if IL-1 beta.

complete
CACAO 9194

protected

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7RTR2

C

Seeded From UniProt

complete

protected

involved_in

GO:0045824

negative regulation of innate immune response

PMID:24560620

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050728

negative regulation of inflammatory response

PMID:24560620

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1900016

negative regulation of cytokine production involved in inflammatory response

PMID:24560620

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032687

negative regulation of interferon-alpha production

PMID:24560620

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032688

negative regulation of interferon-beta production

PMID:24560620

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032715

negative regulation of interleukin-6 production

PMID:24560620

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0036312

phosphatidylinositol 3-kinase regulatory subunit binding

PMID:27951586

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0014067

negative regulation of phosphatidylinositol 3-kinase signaling

PMID:27951586

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048147

negative regulation of fibroblast proliferation

PMID:27951586

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050680

negative regulation of epithelial cell proliferation

PMID:27951586

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7RTR2

C

Seeded From UniProt

complete

protected

involved_in

GO:1901223

negative regulation of NIK/NF-kappaB signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

involved_in

GO:1900226

negative regulation of NLRP3 inflammasome complex assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

involved_in

GO:0050728

negative regulation of inflammatory response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

involved_in

GO:0032691

negative regulation of interleukin-1 beta production

PMID:22863753

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032695

negative regulation of interleukin-12 production

PMID:22863753

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032715

negative regulation of interleukin-6 production

PMID:22863753

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032720

negative regulation of tumor necrosis factor production

PMID:22863753

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042110

T cell activation

PMID:15705585

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:15705585

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

PMID:15705585

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:15705585

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7RTR2

C

Seeded From UniProt

complete

protected

enables

GO:0003674

molecular_function

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2444070
PANTHER:PTN001188547
UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000716087
UniProtKB:Q9HC29
UniProtKB:Q9Y239

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001946600
UniProtKB:Q7RTR2

C

Seeded From UniProt

complete

protected

colocalizes_with

GO:0005737

cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000716087
RGD:1306368
UniProtKB:Q7RTR2
UniProtKB:Q86WI3
UniProtKB:Q9HC29
UniProtKB:Q9Y239
ZFIN:ZDB-GENE-061108-4

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1901223

negative regulation of NIK/NF-kappaB signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1900226

negative regulation of NLRP3 inflammasome complex assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0050728

negative regulation of inflammatory response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q7RTR2

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

PMID:22863753

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108072

P

regulates_o_occurs_in:(CL:0000235)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

PMID:22863753

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000576)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032720

negative regulation of tumor necrosis factor production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032715

negative regulation of interleukin-6 production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032496

response to lipopolysaccharide

PMID:22863753

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5439971

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0031396

regulation of protein ubiquitination

PMID:22863753

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5439971

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0031396

regulation of protein ubiquitination

PMID:22863753

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0007249

I-kappaB kinase/NF-kappaB signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q7RTR2

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q7RTR2

C

Seeded From UniProt

complete

protected

part_of

GO:0005815

microtubule organizing center

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q7RTR2

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q7RTR2

C

Seeded From UniProt

complete

protected

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete




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