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TableEdit
MOUSE:NLRC3
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Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status | |
---|---|---|---|---|---|---|---|---|---|---|---|
public |
GO:0032720 |
negative regulation of tumor necrosis factor production |
PMID:22863753 |
ECO:0000315 |
P |
With knockout mice, Figure 4c graph 1 shows that with stimulation of the TLR on the cell that there is an increased production of the TNF when compared to the WT. |
complete | ||||
public |
GO:0032715 |
negative regulation of interleukin-6 production |
PMID:22863753 |
ECO:0000315 |
P |
Figure 4c graph 2. In knockout mice of the NLCR3 protein then in response to stimulation of TLR then there is an increased amount of IL-6 made when compared to the WT cell. |
complete | ||||
public |
GO:0032695 |
negative regulation of interleukin-12 production |
PMID:22863753 |
ECO:0000315 |
P |
Figure 4c graph 4. With knockout mice of NLRC3 protein when TLR was stimulated there was an increased production of IL-12 when compared to the WT thus indicating that NLRC3 negatively regulates the IL-12 production. |
complete | ||||
public |
GO:0032691 |
negative regulation of interleukin-1 beta production |
PMID:22863753 |
ECO:0000315 |
P |
With knockdown of protein NLRC3 in mice, figure 4c graph 3 indicates that these mice upon TLR stimulation resulted in increased production of IL-1 beta when compared to the WT mice TLR response. This indicates that NLRC3 negatively regulates the production if IL-1 beta. |
complete | ||||
protected |
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q7RTR2 |
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0045824 |
negative regulation of innate immune response |
PMID:24560620 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
PMID:24560620 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:1900016 |
negative regulation of cytokine production involved in inflammatory response |
PMID:24560620 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0032687 |
negative regulation of interferon-alpha production |
PMID:24560620 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0032688 |
negative regulation of interferon-beta production |
PMID:24560620 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
PMID:24560620 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0036312 |
phosphatidylinositol 3-kinase regulatory subunit binding |
PMID:27951586 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0014067 |
negative regulation of phosphatidylinositol 3-kinase signaling |
PMID:27951586 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0048147 |
negative regulation of fibroblast proliferation |
PMID:27951586 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0050680 |
negative regulation of epithelial cell proliferation |
PMID:27951586 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005737 |
cytoplasm |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q7RTR2 |
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:1901223 |
negative regulation of NIK/NF-kappaB signaling |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:1900226 |
negative regulation of NLRP3 inflammasome complex assembly |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0032691 |
negative regulation of interleukin-1 beta production |
PMID:22863753 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0032695 |
negative regulation of interleukin-12 production |
PMID:22863753 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
PMID:22863753 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0032720 |
negative regulation of tumor necrosis factor production |
PMID:22863753 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0042110 |
T cell activation |
PMID:15705585 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
PMID:15705585 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
PMID:15705585 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005737 |
cytoplasm |
PMID:15705585 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q7RTR2 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003674 |
molecular_function |
GO_REF:0000015 |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444070 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0035556 |
intracellular signal transduction |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000716087 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005829 |
cytosol |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001946600 |
C |
Seeded From UniProt |
complete | |
protected |
colocalizes_with |
GO:0005737 |
cytoplasm |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000716087 |
C |
Seeded From UniProt |
complete | |
protected |
acts_upstream_of_or_within |
GO:1901223 |
negative regulation of NIK/NF-kappaB signaling |
GO_REF:0000096 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
acts_upstream_of_or_within |
GO:1900226 |
negative regulation of NLRP3 inflammasome complex assembly |
GO_REF:0000096 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
acts_upstream_of_or_within |
GO:0050728 |
negative regulation of inflammatory response |
GO_REF:0000096 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
GO_REF:0000096 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q7RTR2 |
C |
Seeded From UniProt |
complete | |
protected |
acts_upstream_of_or_within |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
PMID:22863753 |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108072 |
P |
regulates_o_occurs_in:(CL:0000235) |
Seeded From UniProt |
complete |
protected |
acts_upstream_of_or_within |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
PMID:22863753 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0000576) |
Seeded From UniProt |
complete | |
protected |
acts_upstream_of_or_within |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
GO_REF:0000008 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
acts_upstream_of_or_within |
GO:0032720 |
negative regulation of tumor necrosis factor production |
GO_REF:0000096 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
acts_upstream_of_or_within |
GO:0032715 |
negative regulation of interleukin-6 production |
GO_REF:0000096 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
acts_upstream_of_or_within |
GO:0032496 |
response to lipopolysaccharide |
PMID:22863753 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5439971 |
P |
Seeded From UniProt |
complete | |
protected |
acts_upstream_of_or_within |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
GO_REF:0000096 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
acts_upstream_of_or_within |
GO:0031396 |
regulation of protein ubiquitination |
PMID:22863753 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5439971 |
P |
Seeded From UniProt |
complete | |
protected |
acts_upstream_of_or_within |
GO:0031396 |
regulation of protein ubiquitination |
PMID:22863753 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
acts_upstream_of_or_within |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
GO_REF:0000096 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q7RTR2 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005829 |
cytosol |
GO_REF:0000096 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q7RTR2 |
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005815 |
microtubule organizing center |
GO_REF:0000096 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q7RTR2 |
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005737 |
cytoplasm |
GO_REF:0000096 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q7RTR2 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0000166 |
nucleotide binding |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0547 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005737 |
cytoplasm |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0963 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0005524 |
ATP binding |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0067 |
F |
Seeded From UniProt |
complete |
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