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TableEdit
HUMAN:NLRC3
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Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status | |
---|---|---|---|---|---|---|---|---|---|---|---|
public |
GO:0032720 |
negative regulation of tumor necrosis factor production |
PMID:22863753 |
ECO:0000314 |
P |
Overexpression of NLRC3 led to decreased production of TNF through the MyD88 pathway of Hek293 T cells as shown in figure 1b. |
complete | ||||
public |
GO:0032715 |
negative regulation of interleukin-6 production |
PMID:22863753 |
ECO:0000314 |
P |
Figure 1d the second graph indicate that with overexpressed NLRC3 this decreases production of IL-6 in HEK293 t cells. |
complete | ||||
public |
GO:0032720 |
negative regulation of tumor necrosis factor production |
PMID:22863753 |
ECO:0000315 |
P |
Figure 1c shows when NLRC3 is not expressed in HEK293 T cells then the production of TNF in these cells increases indicating that NLRC3 negatively regulates TNF production. |
complete | ||||
public |
GO:0032715 |
negative regulation of interleukin-6 production |
PMID:22863753 |
ECO:0000315 |
P |
Figure 1c shows that when NLRC3 is not expressed concentrations of IL-6 increase indicating that NLRC3 negatively regulates IL-6 production in HEK293 T cells. |
complete | ||||
protected |
part_of |
GO:0005737 |
cytoplasm |
PMID:24560620 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
PMID:24560620 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:1900016 |
negative regulation of cytokine production involved in inflammatory response |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q5DU56 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0045824 |
negative regulation of innate immune response |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q5DU56 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0032688 |
negative regulation of interferon-beta production |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q5DU56 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0032687 |
negative regulation of interferon-alpha production |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q5DU56 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0036312 |
phosphatidylinositol 3-kinase regulatory subunit binding |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q5DU56 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0050680 |
negative regulation of epithelial cell proliferation |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q5DU56 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0048147 |
negative regulation of fibroblast proliferation |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q5DU56 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0014067 |
negative regulation of phosphatidylinositol 3-kinase signaling |
GO_REF:0000024 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q5DU56 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:1901223 |
negative regulation of NIK/NF-kappaB signaling |
PMID:25277106 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
PMID:25277106 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:1900226 |
negative regulation of NLRP3 inflammasome complex assembly |
PMID:25277106 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005737 |
cytoplasm |
PMID:25277106 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
PMID:22863753 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0032720 |
negative regulation of tumor necrosis factor production |
PMID:22863753 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
PMID:22863753 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0032720 |
negative regulation of tumor necrosis factor production |
PMID:22863753 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0042110 |
T cell activation |
PMID:15705585 |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
PMID:15705585 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
PMID:15705585 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005737 |
cytoplasm |
PMID:15705585 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0003674 |
molecular_function |
GO_REF:0000015 |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444070 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0035556 |
intracellular signal transduction |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000716087 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005829 |
cytosol |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001946600 |
C |
Seeded From UniProt |
complete | |
protected |
colocalizes_with |
GO:0005737 |
cytoplasm |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000716087 |
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
PMID:22863753 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005829 |
cytosol |
GO_REF:0000052 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005815 |
microtubule organizing center |
GO_REF:0000052 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005737 |
cytoplasm |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0963 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0000166 |
nucleotide binding |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0547 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0005524 |
ATP binding |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0067 |
F |
Seeded From UniProt |
complete |
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