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PMID:24090070
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| Citation |
Cooper, CA, Mulder, DT, Allison, SE, Pilar, AV and Coombes, BK (2013) The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA. BMC Microbiol. 13:221 |
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| Abstract |
Salmonella enterica is a causative agent of foodborne gastroenteritis and the systemic disease known as typhoid fever. This bacterium uses two type three secretion systems (T3SSs) to translocate protein effectors into host cells to manipulate cellular function. Salmonella pathogenicity island (SPI)-2 encodes a T3SS required for intracellular survival of the pathogen. Genes in SPI-2 include apparatus components, secreted effectors and chaperones that bind to secreted cargo to coordinate their release from the bacterial cell. Although the effector repertoire secreted by the SPI-2 T3SS is large, only three virulence-associated chaperones have been characterized. |
| Links |
PubMed Online version:10.1186/1471-2180-13-221 |
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