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PMID:16952559
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| Citation |
Masyuk, AI, Masyuk, TV, Splinter, PL, Huang, BQ, Stroope, AJ and LaRusso, NF (2006) Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. Gastroenterology 131:911-20 |
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| Abstract |
Cholangiocytes have primary cilia extending from the apical plasma membrane into the ductal lumen. While the physiologic significance of cholangiocyte cilia is unknown, studies in renal epithelia suggest that primary cilia possess sensory functions. Here, we tested the hypothesis that cholangiocyte cilia are sensory organelles that detect and transmit luminal bile flow stimuli into intracellular Ca2+ ([Ca2+]i) and adenosine 3',5'-cyclic monophosphate (cAMP) signaling. |
| Links |
PubMed PMC1866168 Online version:10.1053/j.gastro.2006.07.003 |
| Keywords |
Animals; Bile Ducts, Intrahepatic/metabolism; Bile Ducts, Intrahepatic/ultrastructure; Calcium/metabolism; Calcium Channels/metabolism; Cilia/metabolism; Cilia/ultrastructure; Cyclic AMP/metabolism; Intracellular Fluid/metabolism; Male; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Rats; Rats, Inbred F344; Signal Transduction/physiology; TRPP Cation Channels/metabolism |
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