GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

TableEdit

Jump to: navigation, search

PMID:9359840

You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor

Citation

Machesky, LM, Reeves, E, Wientjes, F, Mattheyse, FJ, Grogan, A, Totty, NF, Burlingame, AL, Hsuan, JJ and Segal, AW (1997) Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. Biochem. J. 328 ( Pt 1):105-12

Abstract

Human neutrophils contain a complex of proteins similar to the actin-related protein 2/3 (Arp2/3) complex of Acanthamoeba. We have obtained peptide sequence information for each member of the putative seven-protein complex previously described for Acanthamoeba and human platelets. From the peptide sequences we have identified cDNA species encoding three novel proteins in this complex. We find that in addition to Arp2 and Arp3, this complex contains a relative of the human (Suppressor of Profilin) SOP2Hs protein and four previously unknown proteins. These proteins localize in the cytoplasm of fibroblasts that lack lamellipodia, but are enriched in lamellipodia on stimulation with serum or platelet-derived growth factor. We propose a conserved and dynamic role for this complex in the organization of the actin cytoskeleton.

Links

PubMed PMC1218893

Keywords

3T3 Cells; Acanthamoeba/chemistry; Actin-Related Protein 2; Actin-Related Protein 3; Actins/chemistry; Actins/genetics; Actins/isolation & purification; Actins/metabolism; Amino Acid Sequence; Animals; Caenorhabditis elegans/genetics; Carrier Proteins/genetics; Cell Movement/genetics; Conserved Sequence; Cytoskeletal Proteins; Evolution, Molecular; Humans; Macromolecular Substances; Mice; Molecular Sequence Data; Neutrophils/chemistry; Protozoan Proteins/genetics; Saccharomyces cerevisiae/genetics; Schizosaccharomyces/genetics

public



Cancel