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PMID:19682396
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| Citation |
Woo, SM, Kim, J, Han, HW, Chae, JI, Son, MY, Cho, S, Chung, HM, Han, YM and Kang, YK (2009) Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells. BMC Neurosci 10:97 |
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| Abstract |
Studies have provided important findings about the roles of Notch signaling in neural development. Unfortunately, however, most of these studies have investigated the neural stem cells (NSCs) of mice or other laboratory animals rather than humans, mainly owing to the difficulties associated with obtaining human brain samples. It prompted us to focus on neuroectodermal spheres (NESs) which are derived from human embryonic stem cell (hESC) and densely inhabited by NSCs. We here investigated the role of Notch signaling with the hESC-derived NESs. |
| Links |
PubMed PMC3224699 Online version:10.1186/1471-2202-10-97 |
| Keywords |
Blotting, Western; Cell Differentiation/physiology; Cell Lineage/physiology; Cells, Cultured; Embryonic Stem Cells/cytology; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Multipotent Stem Cells/cytology; Neural Plate/cytology; Neurogenesis/physiology; Neurons/metabolism; Neurons/physiology; Receptor, Notch1/metabolism; Reverse Transcriptase Polymerase Chain Reaction |
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