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PMID:16217485
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| Citation |
Fong, KD, Trindade, MC, Wang, Z, Nacamuli, RP, Pham, H, Fang, TD, Song, HM, Smith, RL, Longaker, MT and Chang, J (2005) Microarray analysis of mechanical shear effects on flexor tendon cells. Plast. Reconstr. Surg. 116:1393-404; discussion 1405-6 |
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| Abstract |
Adhesion formation after flexor tendon repair remains a clinical problem. Early postoperative motion after tendon repair has been demonstrated to reduce adhesion formation while increasing tendon strength. The authors hypothesized that during mobilization, tendon cells experience mechanical shear forces that alter their biology in a fashion that reduces scar formation but also activates key genes involved in tendon healing. |
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| Keywords |
Animals; Blotting, Northern; Cells, Cultured; Collagen/metabolism; Gene Expression Profiling; Male; Mice; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Tendons/cytology; Tissue Adhesions/physiopathology; Wound Healing/physiology |
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