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HUMAN:F5H1A7

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0016477

cell migration

PMID:22467863

ECO:0000315

P

Figure 1 suggests that depleting radixin decreases cell migration and increases cell area.

complete
CACAO 7881

public

GO:0005912

adherens junction

PMID:22467863

ECO:0000315

C

Figure 3 shows that depletion of radixin increases adherens junctions which suggests that radixin has a role in this process.

complete
CACAO 7885

protected

part_of

GO:0005902

microvillus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26043

C

Seeded From UniProt

complete

protected

enables

GO:0045296

cadherin binding

PMID:25468996

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0072659

protein localization to plasma membrane

PMID:17825285

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • has_direct_input:(UniProtKB:Q92887)
  • occurs_in:(CL:0002563)
  • occurs_at:(GO:0016324)

Seeded From UniProt

complete

protected

involved_in

GO:1903392

negative regulation of adherens junction organization

PMID:22467863

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034111

negative regulation of homotypic cell-cell adhesion

PMID:22467863

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032231

regulation of actin filament bundle assembly

PMID:22467863

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(GO:0071944)

Seeded From UniProt

complete

protected

involved_in

GO:0008360

regulation of cell shape

PMID:22467863

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1900027

regulation of ruffle assembly

PMID:22467863

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045792

negative regulation of cell size

PMID:22467863

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030335

positive regulation of cell migration

PMID:22467863

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0030864

cortical actin cytoskeleton

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

C

  • part_of:(GO:0005902)
  • part_of:(GO:0030175)
  • part_of:(GO:0030027)
  • part_of:(CL:0002258)

Seeded From UniProt

complete

protected

part_of

GO:0030175

filopodium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

C

part_of:(CL:0002258)

Seeded From UniProt

complete

protected

part_of

GO:0030027

lamellipodium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

C

part_of:(CL:0002258)

Seeded From UniProt

complete

protected

part_of

GO:0005902

microvillus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

C

part_of:(CL:0002258)

Seeded From UniProt

complete

protected

colocalizes_with

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

C

part_of:(CL:0002258)

Seeded From UniProt

complete

protected

enables

GO:0051018

protein kinase A binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

F

occurs_in:(CL:0002258)

Seeded From UniProt

complete

protected

involved_in

GO:1900087

positive regulation of G1/S transition of mitotic cell cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

P

  • results_in_division_of:(CL:0002258)
  • happens_during:(GO:0097067)

Seeded From UniProt

complete

protected

involved_in

GO:0097067

cellular response to thyroid hormone stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

P

occurs_in:(CL:0002258)

Seeded From UniProt

complete

protected

involved_in

GO:0045184

establishment of protein localization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

P

  • occurs_at:(GO:0005886)
  • occurs_in:(CL:0002258)
  • has_input:(UniProtKB:O95398)

Seeded From UniProt

complete

protected

involved_in

GO:0032487

regulation of Rap protein signal transduction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

P

  • occurs_in:(CL:0002258)
  • has_input:(UniProtKB:O95398)
  • has_regulation_target:(UniProtKB:Q9NYB0)
  • happens_during:(GO:0097067)
  • causally_upstream_of:(GO:1900087)

Seeded From UniProt

complete

protected

involved_in

GO:0010737

protein kinase A signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5PQK5

P

  • occurs_in:(CL:0002258)
  • causally_upstream_of:(GO:1900087)
  • happens_during:(GO:0097067)

Seeded From UniProt

complete

protected

enables

GO:0051117

ATPase binding

PMID:17825285

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q92887

F

Seeded From UniProt

complete

protected

enables

GO:0003779

actin binding

PMID:17825285

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0016324

apical plasma membrane

PMID:17825285

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002563)

Seeded From UniProt

complete

protected

involved_in

GO:0008361

regulation of cell size

PMID:22467863

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15498,UniProtKB:P52735,UniProtKB:Q9UKW4

P

Seeded From UniProt

complete

protected

involved_in

GO:0043087

regulation of GTPase activity

PMID:22467863

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15498,UniProtKB:P52735,UniProtKB:Q9UKW4

P

has_regulation_target:(UniProtKB:P63000)

Seeded From UniProt

complete

protected

involved_in

GO:0008361

regulation of cell size

PMID:22467863

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P63000

P

Seeded From UniProt

complete

protected

involved_in

GO:0034260

negative regulation of GTPase activity

PMID:22467863

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P63000)

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

PMID:16582480

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P26043

F

Seeded From UniProt

complete

protected

involved_in

GO:1902966

positive regulation of protein localization to early endosome

PMID:21148287

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15311
UniProtKB:P26038

P

has_regulation_target:(UniProtKB:P51149)

Seeded From UniProt

complete

protected

involved_in

GO:1902115

regulation of organelle assembly

PMID:21148287

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15311
UniProtKB:P26038

P

results_in_maturation_of:(GO:0005770)

Seeded From UniProt

complete

protected

involved_in

GO:2000643

positive regulation of early endosome to late endosome transport

PMID:21148287

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15311
UniProtKB:P26038

P

has_input:(UniProtKB:P00533)

Seeded From UniProt

complete

protected

involved_in

GO:1903364

positive regulation of cellular protein catabolic process

PMID:21148287

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15311
UniProtKB:P26038

P

has_regulation_target:(UniProtKB:P00533)

Seeded From UniProt

complete

protected

part_of

GO:0071944

cell periphery

PMID:22291017

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005925

focal adhesion

PMID:21423176

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

protected

part_of

GO:0070062

extracellular exosome

PMID:23533145

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0070062

extracellular exosome

PMID:19199708

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

protected

part_of

GO:0070062

extracellular exosome

PMID:19056867

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

protected

part_of

GO:0070062

extracellular exosome

PMID:20458337

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

protected

involved_in

GO:0061028

establishment of endothelial barrier

PMID:23264465

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15311
UniProtKB:P26038

P

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:23264465

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q96S97

P

  • has_regulation_target:(UniProtKB:P05362)
  • occurs_in:(UBERON:0001986)

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:16502470

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001914)

Seeded From UniProt

complete

protected

colocalizes_with

GO:0005925

focal adhesion

PMID:21282464

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0003723

RNA binding

PMID:22658674

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0051286

cell tip

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

protected

involved_in

GO:0051016

barbed-end actin filament capping

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

P

Seeded From UniProt

complete

protected

involved_in

GO:0045176

apical protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

P

Seeded From UniProt

complete

protected

involved_in

GO:0036120

cellular response to platelet-derived growth factor stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

P

Seeded From UniProt

complete

protected

part_of

GO:0032154

cleavage furrow

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

protected

part_of

GO:0030496

midbody

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

protected

part_of

GO:0030315

T-tubule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

protected

part_of

GO:0005913

cell-cell adherens junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

protected

part_of

GO:0005902

microvillus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

C

Seeded From UniProt

complete

protected

enables

GO:0003779

actin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PT65
ensembl:ENSRNOP00000035840

F

Seeded From UniProt

complete

protected

involved_in

GO:1900087

positive regulation of G1/S transition of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

P

Seeded From UniProt

complete

protected

involved_in

GO:0097067

cellular response to thyroid hormone stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

P

Seeded From UniProt

complete

protected

involved_in

GO:0045184

establishment of protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

P

Seeded From UniProt

complete

protected

part_of

GO:0045177

apical part of cell

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

protected

involved_in

GO:0045176

apical protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

P

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

F

Seeded From UniProt

complete

protected

part_of

GO:0032420

stereocilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

protected

part_of

GO:0030864

cortical actin cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

protected

part_of

GO:0030175

filopodium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

protected

involved_in

GO:0030033

microvillus assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

P

Seeded From UniProt

complete

protected

part_of

GO:0030027

lamellipodium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

protected

enables

GO:0019904

protein domain specific binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

F

Seeded From UniProt

complete

protected

part_of

GO:0005902

microvillus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

protected

part_of

GO:0001726

ruffle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26043
ensembl:ENSMUSP00000000590

C

Seeded From UniProt

complete

protected

enables

GO:0003779

actin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008954
InterPro:IPR011174

F

Seeded From UniProt

complete

protected

part_of

GO:0005856

cytoskeleton

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000299

C

Seeded From UniProt

complete

protected

enables

GO:0008092

cytoskeletal protein binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000798

F

Seeded From UniProt

complete

protected

involved_in

GO:0051693

actin filament capping

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0117

P

Seeded From UniProt

complete

protected

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

protected

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

protected

part_of

GO:0005902

microvillus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0293

C

Seeded From UniProt

complete

protected

part_of

GO:0032154

cleavage furrow

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0467

C

Seeded From UniProt

complete



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