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PMID:23322205

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Citation

Kaliszczak, M, Trousil, S, Åberg, O, Perumal, M, Nguyen, QD and Aboagye, EO (2013) A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth. Br. J. Cancer 108:342-50

Abstract

This study investigates whether a histone deacetylase subtype 6 (HDAC6) inhibitor could be used in the treatment of solid tumours.

Links

PubMed PMC3566806 Online version:10.1038/bjc.2012.576

Keywords

Acetylation/drug effects; Animals; Apoptosis/drug effects; Caspase 3/analysis; Cell Cycle/drug effects; Cell Proliferation/drug effects; Female; Gene Expression/drug effects; HCT116 Cells; HSP90 Heat-Shock Proteins/metabolism; Histone Deacetylase Inhibitors/pharmacology; Histone Deacetylase Inhibitors/therapeutic use; Histone Deacetylases/metabolism; Humans; Hydroxamic Acids/pharmacology; Ki-67 Antigen/analysis; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms/drug therapy; Tubulin/metabolism; Xenograft Model Antitumor Assays

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