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HUMAN:SMUF1

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:2000060

positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

PMID:21454619

ECO:0000315

P

Figure 4 shows how the mutation of this gene affects the regulation of the WFS1 protien

complete
CACAO 7110

protected

involved_in

GO:0030514

negative regulation of BMP signaling pathway

PMID:27214554

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0002591)

Seeded From UniProt

complete

protected

involved_in

GO:0061753

substrate localization to autophagosome

PMID:22020285

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_target_start_location:(GO:0005739)

Seeded From UniProt

complete

protected

involved_in

GO:0061736

engulfment of target by autophagosome

PMID:22020285

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_at:(GO:0005739)

Seeded From UniProt

complete

protected

involved_in

GO:1903861

positive regulation of dendrite extension

PMID:23999003

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000148)

Seeded From UniProt

complete

protected

involved_in

GO:0071211

protein targeting to vacuole involved in autophagy

PMID:22020285

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(UniProtKB:P03316)

Seeded From UniProt

complete

protected

colocalizes_with

GO:0005739

mitochondrion

PMID:22020285

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9CUN6

C

Seeded From UniProt

complete

protected

involved_in

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

PMID:21454619

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0070062

extracellular exosome

PMID:19056867

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

protected

enables

GO:0070412

R-SMAD binding

PMID:11278251

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99717

F

Seeded From UniProt

complete

protected

enables

GO:0070412

R-SMAD binding

PMID:11278251

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P84022

F

Seeded From UniProt

complete

protected

enables

GO:0070412

R-SMAD binding

PMID:11278251

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15797

F

Seeded From UniProt

complete

protected

enables

GO:0070411

I-SMAD binding

PMID:12151385

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O15105

F

Seeded From UniProt

complete

protected

enables

GO:0070411

I-SMAD binding

PMID:11278251

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O43541

F

Seeded From UniProt

complete

protected

enables

GO:0048185

activin binding

PMID:16720724

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:11278251

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:12151385

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034394

protein localization to cell surface

PMID:12151385

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032801

receptor catabolic process

PMID:12151385

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030579

ubiquitin-dependent SMAD protein catabolic process

PMID:12151385

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030579

ubiquitin-dependent SMAD protein catabolic process

PMID:11278251

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

PMID:12151385

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

PMID:11278251

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

PMID:11278251

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006611

protein export from nucleus

PMID:11278251

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:12151385

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:12151385

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:11278251

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0061630

ubiquitin protein ligase activity

PMID:12151385

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:O15105)

Seeded From UniProt

complete

protected

enables

GO:0061630

ubiquitin protein ligase activity

PMID:11278251

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:O15105)

Seeded From UniProt

complete

protected

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:19937093

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:10458166

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030509

BMP signaling pathway

PMID:21572392

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030154

cell differentiation

PMID:10458166

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21572392

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:19937093

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:10458166

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0000209

protein polyubiquitination

PMID:19937093

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0061630

ubiquitin protein ligase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0259174
MGI:MGI:1861728
MGI:MGI:1914144
MGI:MGI:1933754
MGI:MGI:97297
PANTHER:PTN000134256
PomBase:SPAC11G7.02
PomBase:SPAC1805.15c
UniProtKB:P46934
UniProtKB:Q96J02
UniProtKB:Q9HCE7

F

Seeded From UniProt

complete

protected

involved_in

GO:0045732

positive regulation of protein catabolic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202301
MGI:MGI:97297
PANTHER:PTN000134745
RGD:735047
UniProtKB:P46934

P

Seeded From UniProt

complete

protected

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1861728
MGI:MGI:1914144
PANTHER:PTN000134745
SGD:S000000927
UniProtKB:O00308
UniProtKB:Q96PU5
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

protected

involved_in

GO:0030579

ubiquitin-dependent SMAD protein catabolic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000135002
UniProtKB:Q9HAU4
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

protected

involved_in

GO:0030514

negative regulation of BMP signaling pathway

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029006
PANTHER:PTN000135002
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0259174
MGI:MGI:1861728
MGI:MGI:1914144
MGI:MGI:1923038
MGI:MGI:97297
PANTHER:PTN000134256
SGD:S000000927
SGD:S000002865
TAIR:locus:2135630
UniProtKB:O00308
UniProtKB:P46934
UniProtKB:Q5BDP1
UniProtKB:Q8IYU2
UniProtKB:Q96J02
UniProtKB:Q96PU5
UniProtKB:Q9HCE7
WB:WBGene00007009

P

Seeded From UniProt

complete

protected

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029006
PANTHER:PTN000135002
UniProtKB:Q9HAU4
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

protected

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029006
MGI:MGI:1202301
MGI:MGI:97297
PANTHER:PTN000134745
PomBase:SPAC11G7.02
SGD:S000000927
UniProtKB:O15033
UniProtKB:P46934
UniProtKB:Q96J02
UniProtKB:Q96PU5
UniProtKB:Q9HAU4
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003557
FB:FBgn0259174
MGI:MGI:1202301
MGI:MGI:1914144
MGI:MGI:97297
PANTHER:PTN000134256
PomBase:SPAC11G7.02
PomBase:SPAC1805.15c
SGD:S000000927
TAIR:locus:2135630
UniProtKB:P46934
UniProtKB:Q7Z6Z7
UniProtKB:Q9HCE7
WB:WBGene00007009

C

Seeded From UniProt

complete

protected

involved_in

GO:0000209

protein polyubiquitination

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202301
PANTHER:PTN000134745
SGD:S000000927
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

protected

involved_in

GO:0061734

parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CUN6
ensembl:ENSMUSP00000082827

P

Seeded From UniProt

complete

protected

involved_in

GO:0030279

negative regulation of ossification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CUN6
ensembl:ENSMUSP00000082827

P

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CUN6
ensembl:ENSMUSP00000082827

P

Seeded From UniProt

complete

protected

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2K612
ensembl:ENSRNOP00000073635

C

Seeded From UniProt

complete

protected

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2K612
ensembl:ENSRNOP00000073635

C

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000569
InterPro:IPR035983

F

Seeded From UniProt

complete

protected

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024928

P

Seeded From UniProt

complete

protected

enables

GO:0061630

ubiquitin protein ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024928

F

Seeded From UniProt

complete

protected

involved_in

GO:0072659

protein localization to plasma membrane

PMID:22020285

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0005543

phospholipid binding

PMID:22020285

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0030514

negative regulation of BMP signaling pathway

PMID:10458166

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007398

ectoderm development

PMID:10458166

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0061630

ubiquitin protein ligase activity

Reactome:R-HSA-4608852

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0060071

Wnt signaling pathway, planar cell polarity pathway

Reactome:R-HSA-4086400

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030509

BMP signaling pathway

Reactome:R-HSA-201451

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

Reactome:R-HSA-2173791

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-NUL-2176396
Reactome:R-NUL-2169036
Reactome:R-NUL-2169016
Reactome:R-HSA-9009452
Reactome:R-HSA-5635865
Reactome:R-HSA-4608854
Reactome:R-HSA-4608852
Reactome:R-HSA-2160935
Reactome:R-HSA-2160932
Reactome:R-HSA-2160931
Reactome:R-HSA-201821
Reactome:R-HSA-201445

ECO:0000304

author statement supported by traceable reference used in manual assertion












C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

Reactome:R-NUL-2169016
Reactome:R-NUL-2169012
Reactome:R-NUL-2169004
Reactome:R-HSA-8952419

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

protected

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete




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