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MOUSE:WNT2

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0033278

cell proliferation in midbrain

PMID:20018874

ECO:0000315

P

Figure 5 shows lack of Wnt2 gene results in a decrease in midbrain length.

complete
CACAO 6646

public

GO:0050769

positive regulation of neurogenesis

PMID:20018874

ECO:0000314

P

Figure 3 shows increased Wnt2 leads to increased number of DA neurons from precursor cells.

complete
CACAO 6811

public

GO:0016055

Wnt receptor signaling pathway

PMID:20018874

ECO:0000314

P

Figure 2 shows Wnt2 activates the Beta-catenin/Wnt receptor signal pathway.

complete
CACAO 6814

public

GO:0050769

positive regulation of neurogenesis

PMID:20018874

ECO:0000315

P

Figure 5 shows knockout of Wnt2 gene leads to decreased neurogenesis.

complete
CACAO 6816

protected

involved_in

GO:0045165

cell fate commitment

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98957
PANTHER:PTN000246517
UniProtKB:P49339
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

protected

involved_in

GO:0030182

neuron differentiation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246517
RGD:69250
UniProtKB:P56706
UniProtKB:Q98SN7

P

Seeded From UniProt

complete

protected

involved_in

GO:0016055

Wnt signaling pathway

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010194
MGI:MGI:108061
MGI:MGI:1197020
MGI:MGI:98953
MGI:MGI:98954
MGI:MGI:98956
MGI:MGI:98958
MGI:MGI:98960
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
UniProtKB:P41221
UniProtKB:Q98SN7
WB:WBGene00000858
WB:WBGene00003029
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
MGI:MGI:98956
MGI:MGI:98957
PANTHER:PTN000246517
RGD:1311441
RGD:69250
UniProtKB:P41221
UniProtKB:P56704
UniProtKB:P56705
UniProtKB:Q2LMP1
UniProtKB:Q9UBV4
UniProtKB:Q9YGX6

C

Seeded From UniProt

complete

protected

enables

GO:0005109

frizzled binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
FB:FBgn0004360
FB:FBgn0010453
FB:FBgn0038134
MGI:MGI:98956
MGI:MGI:98957
MGI:MGI:98958
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
RGD:69079
UniProtKB:P09544
UniProtKB:P41221
UniProtKB:P56703
UniProtKB:Q98SN7

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0048146

positive regulation of fibroblast proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

protected

enables

GO:0048018

receptor ligand activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20159597

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:107516)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0033278

cell proliferation in midbrain

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

protected

part_of

GO:0031232

extrinsic component of external side of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0016055

Wnt signaling pathway

PMID:11092808

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108571

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0007267

cell-cell signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:23610556

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621346

C

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

F

Seeded From UniProt

complete

protected

enables

GO:0005109

frizzled binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0002053

positive regulation of mesenchymal cell proliferation

PMID:19686689

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4361155

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621346

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1904954

canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1904948

midbrain dopaminergic neuron differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

protected

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060716

labyrinthine layer blood vessel development

PMID:8951051

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2177935

P

results_in_development_of:(EMAPA:16042)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060501

positive regulation of epithelial cell proliferation involved in lung morphogenesis

PMID:19686689

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4361155

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060492

lung induction

PMID:19686689

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1261834

P

has_participant:(EMAPA:16548)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060317

cardiac epithelial to mesenchymal transition

PMID:20159597

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4361155

P

occurs_in:(EMAPA:16546)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060070

canonical Wnt signaling pathway

PMID:19686689

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1261834

P

occurs_in:(EMAPA:16548)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060070

canonical Wnt signaling pathway

PMID:20159597

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4361155

P

occurs_in:(EMAPA:16546)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060070

canonical Wnt signaling pathway

PMID:9652750

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P09544

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060045

positive regulation of cardiac muscle cell proliferation

PMID:20159597

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4361155

P

regulates_o_occurs_in:(EMAPA:17320)|regulates_o_occurs_in:(EMAPA:17326)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0055009

atrial cardiac muscle tissue morphogenesis

PMID:20159597

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4361155

P

has_participant:(EMAPA:17320)|has_participant:(EMAPA:17326)

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048018

P

Seeded From UniProt

complete

protected

involved_in

GO:1904954

canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

protected

involved_in

GO:1904948

midbrain dopaminergic neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

protected

involved_in

GO:0071560

cellular response to transforming growth factor beta stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

protected

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

C

Seeded From UniProt

complete

protected

involved_in

GO:0061180

mammary gland epithelium development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

protected

involved_in

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

protected

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

protected

involved_in

GO:0048146

positive regulation of fibroblast proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

protected

enables

GO:0048018

receptor ligand activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

F

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

protected

involved_in

GO:0033278

cell proliferation in midbrain

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

protected

part_of

GO:0031232

extrinsic component of external side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

C

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

protected

involved_in

GO:0007267

cell-cell signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

C

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

F

Seeded From UniProt

complete

protected

enables

GO:0005109

frizzled binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09544
ensembl:ENSP00000265441

F

Seeded From UniProt

complete

protected

involved_in

GO:0030324

lung development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q2IBD1
ensembl:ENSRNOP00000071025

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q2IBD1
ensembl:ENSRNOP00000071025

C

Seeded From UniProt

complete

protected

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q2IBD1
ensembl:ENSRNOP00000071025

P

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009140

F

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009140

C

Seeded From UniProt

complete

protected

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009140

P

Seeded From UniProt

complete

protected

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009140

P

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

protected

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

protected

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete



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