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HUMAN:IL2

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0042102

positive regulation of T cell proliferation

PMID:24416451

ECO:0000314

P

Figure 1 shows initial reduction of CD4 T-cells when IL-2 is inhibited

complete

protected

involved_in

GO:0002366

leukocyte activation involved in immune response

PMID:16204630

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050729

positive regulation of inflammatory response

PMID:16482511

ECO:0000305

curator inference used in manual assertion

GO:0032740

P

Seeded From UniProt

complete

protected

involved_in

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

PMID:19088061

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034105

positive regulation of tissue remodeling

PMID:16482511

ECO:0000305

curator inference used in manual assertion

GO:0032740

P

Seeded From UniProt

complete

protected

involved_in

GO:0032740

positive regulation of interleukin-17 production

PMID:16482511

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042104

positive regulation of activated T cell proliferation

PMID:1830926

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042104

positive regulation of activated T cell proliferation

PMID:10072077

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030890

positive regulation of B cell proliferation

PMID:9184696

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0005134

interleukin-2 receptor binding

PMID:8262055

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

PMID:1830926

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

PMID:10072077

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0002903

negative regulation of B cell apoptotic process

PMID:9184696

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005623

cell

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0007204

C

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

protected

involved_in

GO:0033674

positive regulation of kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0019209

P

Seeded From UniProt

complete

protected

involved_in

GO:2000320

negative regulation of T-helper 17 cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

P

Seeded From UniProt

complete

protected

involved_in

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

P

Seeded From UniProt

complete

protected

involved_in

GO:0051024

positive regulation of immunoglobulin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

P

Seeded From UniProt

complete

protected

involved_in

GO:0050728

negative regulation of inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

P

Seeded From UniProt

complete

protected

involved_in

GO:0050672

negative regulation of lymphocyte proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

P

Seeded From UniProt

complete

protected

involved_in

GO:0048304

positive regulation of isotype switching to IgG isotypes

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

P

Seeded From UniProt

complete

protected

involved_in

GO:0046013

regulation of T cell homeostatic proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

P

Seeded From UniProt

complete

protected

involved_in

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

P

Seeded From UniProt

complete

protected

involved_in

GO:0042104

positive regulation of activated T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

P

Seeded From UniProt

complete

protected

involved_in

GO:0042102

positive regulation of T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

P

Seeded From UniProt

complete

protected

involved_in

GO:0032729

positive regulation of interferon-gamma production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

C

Seeded From UniProt

complete

protected

enables

GO:0005134

interleukin-2 receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04351
ensembl:ENSMUSP00000029275

F

Seeded From UniProt

complete

protected

involved_in

GO:0060999

positive regulation of dendritic spine development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

P

Seeded From UniProt

complete

protected

involved_in

GO:0045822

negative regulation of heart contraction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

P

Seeded From UniProt

complete

protected

involved_in

GO:0045591

positive regulation of regulatory T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

P

Seeded From UniProt

complete

protected

involved_in

GO:0045582

positive regulation of T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

P

Seeded From UniProt

complete

protected

involved_in

GO:0045471

response to ethanol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

P

Seeded From UniProt

complete

protected

enables

GO:0043208

glycosphingolipid binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

F

Seeded From UniProt

complete

protected

involved_in

GO:0042102

positive regulation of T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

P

Seeded From UniProt

complete

protected

enables

GO:0031851

kappa-type opioid receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

F

Seeded From UniProt

complete

protected

enables

GO:0030246

carbohydrate binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

F

Seeded From UniProt

complete

protected

involved_in

GO:0007205

protein kinase C-activating G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

P

Seeded From UniProt

complete

protected

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

P

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

C

Seeded From UniProt

complete

protected

enables

GO:0005134

interleukin-2 receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

F

Seeded From UniProt

complete

protected

involved_in

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

P

Seeded From UniProt

complete

protected

involved_in

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17108
ensembl:ENSRNOP00000023327

P

Seeded From UniProt

complete

protected

enables

GO:0005134

interleukin-2 receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000779

F

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000779

C

Seeded From UniProt

complete

protected

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000779

P

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000779

F

Seeded From UniProt

complete

protected

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:8476561

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030307

positive regulation of cell growth

PMID:8476561

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030217

T cell differentiation

PMID:8476561

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030101

natural killer cell activation

PMID:8476561

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0019209

kinase activator activity

PMID:8476561

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:8476561

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

PMID:8476561

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007267

cell-cell signaling

PMID:8476561

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007155

cell adhesion

PMID:10929056

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006955

immune response

PMID:2342538

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:6608729

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0005134

interleukin-2 receptor binding

PMID:3925347

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0045589

regulation of regulatory T cell differentiation

Reactome:R-HSA-8877330

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0038110

interleukin-2-mediated signaling pathway

Reactome:R-HSA-9020558

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0019221

cytokine-mediated signaling pathway

Reactome:R-HSA-512988
Reactome:R-HSA-451927

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

Reactome:R-HSA-919404
Reactome:R-HSA-913424
Reactome:R-HSA-913374
Reactome:R-HSA-912527
Reactome:R-HSA-8877345
Reactome:R-HSA-5672965
Reactome:R-HSA-508292
Reactome:R-HSA-508282
Reactome:R-HSA-508247
Reactome:R-HSA-453111
Reactome:R-HSA-453104
Reactome:R-HSA-452122
Reactome:R-HSA-452108
Reactome:R-HSA-452100
Reactome:R-HSA-452097
Reactome:R-HSA-452091
Reactome:R-HSA-451942
Reactome:R-HSA-450063
Reactome:R-HSA-450054
Reactome:R-HSA-450027

ECO:0000304

author statement supported by traceable reference used in manual assertion




















C

Seeded From UniProt

complete

protected

involved_in

GO:0000165

MAPK cascade

Reactome:R-HSA-5673001

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

protected

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

protected

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete



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