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PMID:22885984
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| Citation |
van Gisbergen, KP, Kragten, NA, Hertoghs, KM, Wensveen, FM, Jonjic, S, Hamann, J, Nolte, MA and van Lier, RA (2012) Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation. Nat. Immunol. 13:864-71 |
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| Abstract |
The transcriptional repressor Blimp-1 mediates the terminal differentiation of many cell types, including T cells. Here we identified Hobit (Znf683) as a previously unrecognized homolog of Blimp-1 that was specifically expressed in mouse natural killer T cells (NKT cells). Through studies of Hobit-deficient mice, we found that Hobit was essential for the formation of mature thymic NKT cells. In the periphery, Hobit repressed the accumulation of interferon-γ (IFN-γ)-producing NK1.1(lo) NKT cells at steady state. After antigenic stimulation, Hobit repressed IFN-γ expression, whereas after innate stimulation, Hobit induced granzyme B expression. Thus, reminiscent of the function of Blimp-1 in other lymphocytes, Hobit controlled the maintenance of quiescent, fully differentiated NKT cells and regulated their immediate effector functions. |
| Links |
PubMed Online version:10.1038/ni.2393 |
| Keywords |
Amino Acid Sequence; Animals; Cell Differentiation/genetics; Cell Differentiation/immunology; Flow Cytometry; Mice; Mice, Knockout; Molecular Sequence Data; Natural Killer T-Cells/cytology; Natural Killer T-Cells/immunology; Phylogeny; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors/genetics |
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